TY - JOUR A1 - Mandai, Kyoko A1 - Yamamoto, Tetsuya A1 - Mandai, Hiroki A1 - Nagaki, Aiichiro T1 - Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide JF - Beilstein Journal of Organic Chemistry PY - 2022/// VL - 18 SP - 660 EP - 668 SN - 1860-5397 DO - 10.3762/bjoc.18.67 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.18.67 KW - air KW - continuous flow KW - cyclohexene oxide KW - flow epoxidation KW - rapid gas–liquid reaction N2 - The enhanced reaction rate in the epoxidation of cyclohexene with air as an oxidant was discovered without any added catalyst utilizing a continuous flow reactor constructed with readily available stainless steel parts and devices. This continuous-flow process demonstrates a significant improvement in reaction time for highly selective epoxide production over the batch process due to the efficient mass transfer between the liquid phase and air. The flow process discovered was operated continuously with good operational stability, evaluated by a constant high yield of cyclohexene oxide, to obtain the desired product with high productivity. ER -