TY - JOUR A1 - Kubota, Koji A1 - Baba, Emiru A1 - Seo, Tamae A1 - Ishiyama, Tatsuo A1 - Ito, Hajime T1 - Palladium-catalyzed solid-state borylation of aryl halides using mechanochemistry JF - Beilstein Journal of Organic Chemistry PY - 2022/// VL - 18 SP - 855 EP - 862 SN - 1860-5397 DO - 10.3762/bjoc.18.86 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.18.86 KW - ball mill KW - borylation KW - cross-coupling KW - mechanochemistry KW - solid-state reaction N2 - This study describes the solid-state palladium-catalyzed cross-coupling between aryl halides and bis(pinacolato)diboron using ball milling. The reactions were completed within 10 min for most aryl halides to afford a variety of synthetically useful arylboronates in high yields. Notably, all experimental operations could be performed in air, and did not require the use of large amounts of dry and degassed organic solvents. The utility of this method was further demonstrated by gram-scale synthesis under solvent-free, mechanochemical conditions. ER -