TY - JOUR A1 - Prakash, G. K. Surya A1 - Zhao, Xiaoming A1 - Chacko, Sujith A1 - Wang, Fang A1 - Vaghoo, Habiba A1 - Olah, George A. T1 - Efficient 1,4-addition of α-substituted fluoro(phenylsulfonyl)methane derivatives to α,β-unsaturated compounds JF - Beilstein Journal of Organic Chemistry PY - 2008/// VL - 4 SP - 17 SN - 1860-5397 DO - 10.3762/bjoc.4.17 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.4.17 N2 - The 1,4-addition of a monofluoromethyl nucleophile to a variety of α,β-unsaturated compounds has been achieved under mild conditions using either phosphines or potassium carbonate at room temperature. α-Substituted fluoro(phenylsulfonyl)methane easily undergoes Michael addition to α,β-unsaturated ketones, esters, nitriles, sulfones, as well as propynoates at room temperature to yield the corresponding adducts in moderate to excellent yields. ER -