TY - JOUR A1 - Shore, Gjergji A1 - Tsimerman, Michael A1 - Organ, Michael G. T1 - Gold film-catalysed benzannulation by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS) JF - Beilstein Journal of Organic Chemistry PY - 2009/// VL - 5 SP - 35 SN - 1860-5397 DO - 10.3762/bjoc.5.35 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.5.35 KW - benzannulation KW - flow synthesis KW - gold catalysis KW - microwave KW - thin metal film N2 - Methodology has been developed for laying down a thin gold-on-silver film on the inner surface of glass capillaries for the purpose of catalysing benzannulation reactions. The cycloaddition precursors are flowed through these capillaries while the metal film is being heated to high temperatures using microwave irradiation. The transformation can be optimized rapidly, tolerates a wide number of functional groups, is highly regioselective, and proceeds in good to excellent conversion. ER -