TY - JOUR A1 - Lin, Jing A1 - Qiu, Xiao-Long A1 - Qing, Feng-Ling T1 - Synthesis of gem-difluoromethylenated analogues of boronolide JF - Beilstein Journal of Organic Chemistry PY - 2010/// VL - 6 SP - 37 SN - 1860-5397 DO - 10.3762/bjoc.6.37 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.6.37 KW - boronolide KW - gem-difluoromethylenated analogues KW - gem-difluoropropargylation KW - α,β-unsaturated-δ-lactones N2 - The straightforward synthesis of four gem-difluoromethylenated analogues 4–7 of boronolide is described. The key steps of the synthesis include the concise preparation of the key intermediates 12a–b through the indium-mediated gem-difluoropropargylation of aldehyde 9 with the fluorine-containing building block 11 and the efficient construction of α,β-unsaturated-δ-lactones 15a–b via BAIB/TEMPO-procedure. ER -