TY - JOUR A1 - Martin, Anthony R. A1 - Chartoire, Anthony A1 - Slawin, Alexandra M. Z. A1 - Nolan, Steven P. T1 - Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles JF - Beilstein Journal of Organic Chemistry PY - 2012/// VL - 8 SP - 1637 EP - 1643 SN - 1860-5397 DO - 10.3762/bjoc.8.187 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.8.187 KW - C–H functionalization KW - direct arylation KW - heterocycles KW - N-heterocyclic carbenes KW - palladium N2 - The use of [Pd(NHC)(cinnamyl)Cl] precatalysts in the direct arylation of heterocycles has been investigated. Among four different precatalysts, [Pd(SIPr)(cinnamyl)Cl] proved to be the most efficient promoter of the reaction. The C–H functionalization of sulfur- or nitrogen-containing heterocycles has been achieved at low catalyst loadings. These catalyst charges range from 0.1 to 0.01 mol % palladium. ER -