TY - JOUR A1 - Tigchelaar, Andrew A1 - Tam, William T1 - Iridium-catalyzed intramolecular [4 + 2] cycloadditions of alkynyl halides JF - Beilstein Journal of Organic Chemistry PY - 2012/// VL - 8 SP - 1765 EP - 1770 SN - 1860-5397 DO - 10.3762/bjoc.8.201 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.8.201 KW - alkynyl halide KW - cycloaddition KW - diene-tethered alkyne KW - iridium KW - transition-metal catalyst N2 - Iridium-catalyzed intramolecular [4 + 2] cycloadditions of diene-tethered alkynyl halides were investigated by using [IrCl(cod)]2 as catalyst, and dppe was found to be the most suitable phosphine ligand for the reaction. No oxidative insertion of the iridium into the carbon–halide bond was observed, and the reactions proceeded to provide the halogenated cycloadducts in good yield (75–94%). These results are the first examples of cycloadditions of alkynyl halides using an iridium catalyst. ER -