Tandem Cu-catalyzed ketenimine formation and intramolecular nucleophile capture: Synthesis of 1,2-dihydro-2-iminoquinolines from 1-(o-acetamidophenyl)propargyl alcohols

Summary The copper-catalyzed ketenimine formation reaction of 1-(o-acetamidophenyl)propargyl alcohols with various sulfonyl azides is found to undergo a concomitant intramolecular nucleophile attack to generate 1,2-dihydro-2-iminoquinolines after aromatization (via elimination of acetyl and hydroxy groups) and tautomerization. The reaction produces 4-substituted and 3,4-unsubstituted title compounds in moderate to good yields under mild reaction conditions.

Most recently, we have disclosed a method for the synthesis of E-α,β-unsaturated amides from propargyl acetates via copper catalyzed ketenimine formation with sulfonyl azides (Scheme 1) [16]. The reaction was thought to proceed through intramolecular nucleophilic attack on the in situ generated ketenimine. We became curious to know the fate of the reaction in the presence of another internal nucleophile in the same distance (6-membered) as a competitor.

Results and Discussion
Thus, we synthesized a substrate 3 (from 1 via 2a) through Grignard reaction followed by acetylation (Scheme 2). Substrate 3 contains two nucleophiles in the form of acetyl and acetamide groups at equal distance. When we treated 3 with similar reaction conditions (TsN 3 , 10 mol % CuI, 1.2 equiv K 2 CO 3 , 0.1 M CH 3 CN) as used in the previous method, surprisingly, only α,β-unsaturated amide 5 was obtained as a single product through acetyl migration on the intermediate 4.
No trace of product through acetamide attack was obtained, which was probably due to the weaker nucleophilic nature of the latter nucleophile. We then wanted to test the method on 2a which contains a hydroxy group as a nucleophile for a relatively strained 4-membered attack and the acetamide group for the 6-membered attack. In our earlier study, the hydroxy group was found to be a less effective nucleophile compared to the acetyl group in such a reaction, as the earlier requires higher energy for its strained 4-membered cyclization. In light of this, we speculated that the acetamide group might have more chances for the cyclization in the tentative intermediate 6. As expected, the reaction on 2a proceeded through a 6-membered cyclization to form 7 which underwent aromatization via elimination of acetic acid to produce 8. Product 8 exists in tautomerized form of 9 (vide infra, X-ray structure of 9j). In fact, an elegant synthesis of such compounds was earlier achieved by Wang et al. through three component coupling reaction under similar conditions [13]. The method was shown to be not working for the synthesis of 4-unsubstituted adducts as the 2-aminobenzaldehyde was found to be unreactive in the given conditions and, moreover, the reaction is not possible with acetylene as the alkyne partner to produce 3,4-unsubstituted adducts. We herein report the intramolecular version of Wang's protocol for the synthesis of differently substituted products.
To explore the practicality of the above reaction, a series of starting materials were selected with the variation in substitution on propargyl alcohols as well as sulfonyl azides. It was found that the cascade process was applicable for a wide range of substrates providing the dihydroquinoline derivatives 9 in yields ranging from 36% to 77% (Scheme 3). Initially, we screened 2-propargyl alcohols prepared from aminobenzaldehydes as they were unreactive in Wang's protocol. Thus, 2a was treated with various sulfonyl azides. Trifluoromethanesulfonyl azides reacted similar to toluenesulfonyl azide to afford the products 9b and 9c in 71% and 55% yields. The lower yield in case of 9c can be attributed to the steric hindrance created by the bulky triflruoromethyl group at the ortho position. Benzeneand methanesulfonyl azides produced the corresponding products (9d and 9e) in somewhat lower yields (46% and 36%, respectively). Fluorinated 2 o -propargyl alcohol 2b was then reacted with various aryl sulfonyl azides to get the corresponding products 9f-i in yields ranging from 45-50%.
Next, 3 o -propargyl alcohols prepared from aminoacetophenones and aminobenzophenones were subjected to the title reaction for the synthesis of 4-methyl/phenyl-1,2-dihydro-2-iminoquinolines. It was found that these 3 o -propargyl alcohols were more productive compared to the above 2 o -propargyl alcohols.
Thus 2c-f were subjected to the standard reaction conditions with various sulfonyl azides to get the corresponding 4-alkylsubstituted quinoline derivatives 9j-o in 48-77% yields. In further exploration, 4-phenyl-substituted adducts 9p and 9q were synthesized from 2g and 2h in 61% and 72% yields, respectively. Halogen groups (chloro and fluoro) on the core part as well as the pendant phenyl ring survived well in the reaction to produce the products (9r-t) in yields ranging from 55% to 69%. Electron rich phenyl substrate 2l produced the corresponding product 9u in 65% yield while electron poor substrate 2m was found to be unreactive in the reaction.
The structures of the products were confirmed by 1 H NMR, 13 C NMR and High Resolution Mass Spectrometry (HRMS).
X-ray crystallography of one of the compounds, 9j, gave unambiguous structure confirmation (Figure 1). See also Supporting Information File 1, pages S49-S57 and Supporting Information File 2.

Conclusion
We have described a method for the synthesis of 1,2-dihydro-2iminoquinolines, tautomerized products of 2-tosylaminoquinolines, from 1-(o-acetamidophenyl)propargyl alcohols through copper-catalyzed ketenimine formation with various sulfonyl azides and concomitant intramolecular nucleophilic attack. The method is overall an intramolecular version of the Wang's protocol for the synthesis of differently substituted 1,2-dihydro-2-tosyliminoquinolines which cannot be synthesized by the latter method. The reaction was performed under mild conditions to obtain the products in good yields and with a broad spectrum of substitution patterns.

Experimental
General information: All reagents and solvents were purchased from commercial sources and used without purification. NMR spectra were recorded with a 300 or 400 MHz spectrometer for 1 H NMR, 75 or 100 MHz for 13 C NMR spectroscopy. Chemical shifts are reported relative to tetramethylsilane in CDCl 3 or to residual signals of undeuterasted solvent CDCl 3 /DMSO-d 6 for 1 H and 13 C NMR spectroscopy. Multiplicities are reported as follows: singlet (s), doublet (d), broad singlet (bs), doublet of doublets (dd), doublet of triplets (dt), triplet (t), quartet (q), multiplet (m). HRMS spectra were recorded by using a QTof mass spectrometer. Column chromatography was performed with silica gel (100-200 mesh) as the stationary phase. All reactions were monitored by using TLC. The purity and characterization of compounds were further established by using HRMS.

Supporting Information
Supporting Information File 1 Analytical data.
[http://www.beilstein-journals.org/bjoc/content/ supplementary/1860-5397-10-125-S2.cif] Dr. Tejender S. Thakur of Molecular and Structural Biology Division, CSIR-Central Drug Research Institute for supervising the X-ray data collection and structure determination of 9j reported in this paper. We gratefully acknowledge the financial support by CSIR-Network project 'BSC0102' (CSIR-CDRI-THUNDER) and by DST under the 'Fast Track Proposal Scheme for Young Scientists'. CDRI Communication No. 8678.