Anionic sigmatropic-electrocyclic-Chugaev cascades: accessing 12-aryl-5-(methylthiocarbonylthio)tetracenes and a related anthra[2,3-b]thiophene

1,4-Diols resulting from the double addition of ArCCLi (Ar = Ph, substituted phenyl, 2-thienyl) to ortho-C6H4(CHO)2 undergo cascades to tetracenes on simple admixture of LiHDMS, CS2 and MeI. Acene formation proceeds by [3,3]-sigmatropic rearrangement of xanthate anions followed by 6π electrocyclisations. The reactions are terminated by E2 or anionic Chugaev-type eliminations. Structural packing motifs and electronic properties are reported for the tetracenes.


Introduction
In recent years polyacenes, especially tetra-and pentacenes, have been in the vanguard of new field effect and other organic electronic based devices [1,2]. Although the simple parent acenes have useful device characteristics in their own right, it is often desirable to be able to tune this performance by use of suitable substituted variants [3,4]. Unfortunately, attaining such derivatives rapidly through simple chemistry is often problematic [5,6]. Cross-coupling approaches (formally an excellent approach for acene library preparation) [7][8][9][10][11][12][13] are often hindered by the insolubility, or poor availability, of the parent haloacenes. Conversely, stepwise synthesis of a family of acene derivatives from various acyclic precursors is normally very step intensive. The prevalence of these issues in the synthesis of substituted tetracenes caused Lin [14], building on the anthracycline natural product work of Saá [15], to introduce a 1,2-bisallene cascade approach for rapid access to tetracene sulfoxides in 2007 (Scheme 1).

Scheme 2:
Proposed access to aryl substituted 5-thiolatotetracene derivatives. strategies Lin relied on PhSOH elimination while Liu relied on ubiquitous palladium β-hydride steps leading to tetracenes 3 and 4. We are interested in very efficient routes to tetracene derivatives containing one or more thiolate (SH) groups for the use in highly electrically conducting organics. In this regard we were attracted by a single result in the early literature [17] showing that traces of allenes related to 2 (X = SCOSMe) were accessible via nominal [3,3]-sigmatropic rearrangements of xanthates. As the thiocarbamate products derived from these are predicted to be easily hydrolised to thiolates this potentially offers a simple route to a protected SH analogue of 3. Lin's chemistry [14] cannot be used as no simple method to modify SOPh to SH is available. We proposed that use of starting material xanthate 1c should provide suitably protected 5-thiotetracene derivatives directly (Scheme 2).
The required [3,3]-sigmatropic rearrangements and subsequent 6π elecrocyclisations of 1c have precise stereochemical requirements (Scheme 2). Only the meso diastereomer of 1c is predicted by Woodward-Hoffman analyses [18] to deliver anti-6 that is required for facile E2 elimination leading to the desired tetracene 7 under thermal conditions. However, the initially required 1c are typically attained as ca. 1:1 rac/meso mixtures and this might be expected to limit the potential yield of 7 to only 50% under simple heating (in the absence of other factors).
Houk has demonstrated that both electronic donor or acceptor and steric effects favour placing the larger/most electronically biased substituent 'outwards' in disrotatory 6π processes [19]. This might also depopulate 5 limiting the final yield of 7. However, the following factors suggested to us the viability of Scheme 2: (i) traces of allenes have been observed when preparing xanthates from propargylic alcohols [17]; (ii) the relative van der Waals volumes of SOPh, Ph, CS 2 − and C(=S)SMe (104.2, 76.9, 63.4, and 82.0 Å 3 , respectively [20]) and related electronic properties [σ(SOMe) +0.52, σ(Ph) +0.06, σ(SCOMe) +0.39 [21]] and the work of Lin [14] suggest that significant populations of intermediate 5, with 'inward Ph' should be accessible; (iii) even if a rac-diol is used in the cascade, the possibility of aromatisation of 6 through Chugaev [22] syn elimination. Finally the system of Scheme 2 provides a unique opportunity to probe if these rearrangements do indeed proceed from the neutral xanthates 1c or via the previously unprecedented 1d-2d-6d anionic cascades.

Results and Discussion
Investigation of the chemistry of Scheme 2 commenced with the preparation of the required diols 8 through simple acetylide addition to o-phthalaldehyde (60-91% yield, see Supporting Information File 1). All of the additions proceeded in high yield, but under all conditions tried, no strong bias to either the rac or meso diastereomer could be realised. The meso enriched diastereomer of 8a could be realised by treating rac/meso mixtures of bis-lithium alkoxide of 8a with freshly prepared anhydrous NBu 4 F (2 equivalents) [23] (Scheme 3). Acid quench of the resultant purple dianion leads to ca. 5:1 meso:rac 8a. We assign this transformation to an equilibrium between dialkoxide 9 and the benzylic anion 10. Intramolecular proton delivery via cyclic transition state 11 is proposed to favour the meso dialkoxide prior to protonic quench. Samples of rac enriched 8a were prepared from Sonogashira coupling of anti enriched 8j. The latter could be prepared directly from o-bromobenzaldehyde as shown (Scheme 3) with ca. 1:7 syn:anti enrichment by recrystallisation from CHCl 3 . The enantiotopic ArCH signals of rac-8a are split into separate signals upon treatment with Eu(facam) 3 confirming it to be the C 2 chiral diastereomer while no equivalent splitting in 1 H NMR samples of 8a prepared from purple 11 (in line with it being the meso diastereomer). These assignments are in line with the finding of Saá [15]. The chemical shifts of the methine CHOH proton in rac-8a (δ H 6.20) and meso-8a (δ H 6.33) reflect an equivalent trend in diols 8b-f where two distinct sets of equivalent signals are seen δ H 6.14-6.20 and δ H 6.23-6.35. On this basis we assign the higher chemical shift signal to the meso diastereomer.
Cascade optimisation (Table 1) was carried out using 8a in THF unless otherwise stated. Typically diol 8a (ca. 1:1 rac:meso) was deprotonated at an initial low temperature (T 1 ), then treated sequentially with CS 2 and MeI before finally being brought to a second higher temperature (T 2 ) to facilitate aromatisation leading to 7a (see Supporting Information File 1 for full optimisation details). Simply allowing −78 °C solutions of the dialkoxide to warm slowly to ambient temperature in the presence of excess CS 2 /MeI provided small amounts of tetracene 7a (   These results very strongly suggest unprecedented anionic [3,3]-sigmatropic rearrangement starting from 1d; another addition to the body of evidence for the importance of charge upon sigmatropic rearrangements [25,26]. In the subsequent cascade the second 6π electrocyclisation appears rate limiting. The yield of 7a in run 6 (60%) indicates conversion via syn-6d (unprecedented anionic Chugaev elimination) is possible to some extent. If only E2 termination of the cascade was possible (i.e., via anti-6) a maximum yield of 52% 7a should be realised from the 1:1. In all reactions of Table 2 there is some unrecovered material. One common byproduct is an intensely red compound detected at high R f (0.82, 4:1 pentane/CH 2 Cl 2 ) in TLC analyses conducted under argon. The very high air sensitivity of this compound prevents its characterisation but it is tentatively ascribed to a mixture (12, Scheme 4) of hydroquinone and its monomethylether on the basis of partial 1 H NMR spectrum and ESI mass spectra.
The poorly performing runs of Table 1  The use of the optimal conditions provided a series of acene derivatives ( Table 2). All reactions resulted in chromatographically stable red microcrystalline solids. As anionic Chugaev elimination appeared the preferred aromatisation route from the studies of Table 1 (compare runs 6, 8 and 9), preparations of 7a-c strongly benefit from higher rac:meso ratios that increase the population of the equivalent syn-6 intermediates (Scheme 2). Steric congestion in the anion Chugaev transition state appears to favour this as all these compounds are isolated in good to excellent yields. Conversely 7e-h are isolated in lower yields due to a combination of higher meso content in 8e-h (leading less efficient E2 elimination) and lower steric promotion in the anion Chugaev elimination. Steric, rather than electronic, factors seem to affect the reaction most as evidenced by the quantitative yield of 7d compared to 7b (47%), 7c (56%), 7f (44%) and 7g (38%). The decreasing yields suggest that meta substitution promotes the 6π cyclisation while para electronic affects are minor and unhelpful according to the observed trend. Increasing the reaction temperature, in attempts to facilitate E2 elimination, was generally not useful as this led only to increased amounts of inert xanthates through sulfur alkylation. However, in the case of 7h this approach did allow us to reach 50 ± 4% yields (range for 6 runs).
Compounds 7a, d, f-h and j were subjected to single-crystal X-ray crystallography. This confirmed the molecular connectivity but more importantly allowed insight into their crystal packing features (Scheme 5 and Supporting Information File 1) across the family of structures. Pairs of 7a associate with slipstack pairing (C π ···C π 3.51-3.72 Å). Each of these (7a) 2 'dimers' is linked to the next through π contacts to the xanthate methyl (C π ···MeS 3.38 Å). The 'gaps' in the columns are filled by an additional motif (C π ···C π 3.32-3.59 Å) almost perpendicular to the stacking. In 7d a lattice of (7d) n chains propagates through C(11) π ···MeS (3.39 Å) contacts. Adjacent chains overlap to produce the partial brickwork stack motif showing C π ···C π 3.51-3.60 Å between the most electron rich and deficient aryl rings. Offset stacking ribbons are found in 7f (i.e., graphic 'a' is above 'b', etc.). The closest contacts are C···C edge at 3.82-3.96 Å and C π ···F-CF 2 3.2 Å. Perpendicular ribbons propagate through the crystal linked by inter-digitated xanthates or CF 3 groups. Structure 7f is the only one of the di/trisubstituted family not to show local C 2 symmetry in intermolecular paring of the tetracenes. The structures of 7g,h (Scheme 5) are closely related to those of 7d and 7a, respectively. Finally, the least substituted tetracene 7j forms ribbons of herringbone structures.
Estimates of the HOMO-LUMO data for 7 were taken from UV and CV measurements (see Table 3 and Supporting Information File 1), as well as by DFT calculations. Tetracenes 7d and 7f show the widest range in HOMO-LUMO perturbation while E g opt. is ca. 0.4 eV lower that E g calcd. across the series. We could not attain the reduction potentials of 7 but from the onset of oxidation data we could estimate the HOMO energy levels in 7 and these followed the same trend as E HOMO calcd. Preliminary testing of vacuum deposited thin polycrystalline films (ca. 800 nm) of 7a and 7j showed dielectric behaviour (σ <10 −10 S cm −1 ) indicating that additional derivitisation and radical cation salt formation is required for the attainment of high electrical conductivity, as in the case of tetrathiotetracene [30].

Conclusion
Typical [3,3]-sigmatropic rearrangements of xanthates are normally considered to proceed via neutral species (such as 1c). The tetracenes 7 herein are not formed this way, instead the evidence here strongly suggests that the required [3,3]-6π-6π electrocyclic cascades takes place via anionic xanthate species before final capping with methyl iodide. Final aromatisation through E2 or the anionic equivalent of the Chugaev reaction are also both viable. As neutral Chugaev reactions normally require very high temperatures this alternative approach is attractive as only moderate temperatures are required (60-80 °C). This procedure allows rapid access to mono sulfurcontaining acenes, and is applicable to small scale library synthesis. Only low cost reagents are required and otherwise difficult to synthesise hindered 1,3,4,12-tetrasubstituted species can be made straightforwardly.

Supporting Information
Supporting Information File 1 Experimental procedures, characterisation data, X-ray structures, data for the DFT calculations, and NMR spectra.
[http://www.beilstein-journals.org/bjoc/content/ supplementary/1860-5397-11-31-S1.pdf] Computational Service. We thank Dr. Darren Walsh (University of Nottingham) for the help with the electrochemical studies. We thank European Thermodynamics for their involvement in the programme (JR) and use of the I19 Diamond Facility [31] is acknowledged.