A survey of chiral hypervalent iodine reagents in asymmetric synthesis

The recent years have witnessed a remarkable growth in the area of chiral hypervalent iodine chemistry. These environmentally friendly, mild and economic reagents have been used in catalytic or stoichiometric amounts as an alternative to transition metals for delivering enantioenriched molecules. Varieties of different chiral reagents and their use for demanding asymmetric transformations have been documented over the last 25 years. This review highlights the contribution of different chiral hypervalent iodine reagents in diverse asymmetric conversions.


Introduction
It is more than one century ago since the discovery of the first hypervalent iodine reagent (HIR) [1] and hypervalent iodine chemistry has started to flourish as one of the important and leading areas in organic synthesis. In recent years many excellent reviews have detailed the bonding, reactivity, synthesis, and uses of hypervalent iodine reagents [2][3][4][5][6][7][8][9][10][11][12][13][14]. These compounds feature a unique three-centered four-electron bond [15][16][17][18][19][20] that renders them valuable and important alternatives to transition-metal chemistry. Over the last 25 years hypervalent iodine reagents have gained growing application due to their reduced toxicity, ready availability and lower costs as replace-ment for transition metals leading to several "metal-free" like chemical transformations.
The ongoing demand of modern synthetic chemistry for the development of catalytic enantioselective C-C bond formation reactions turned the attention of the scientific community towards the evolution of new chiral hypervalent iodine reagents. In recent years, many complex synthetic challenges have been successfully addressed by applying these reagents [21,22]. The superior advantage of these reagents lies in their strong electrophilicity and appreciable oxidizing properties. The transformat-ions associated with asymmetric induction mainly focused on the asymmetric oxidation and oxidative dearomatization chemistry. Asymmetric difunctionalization of alkenes, α-functionalization of carbonyls and also some typical 1,2-aryl rearrangement reactions add further value to this chemistry.
The strategies used for the synthesis of chiral hypervalent iodine reagents include either the introduction of chirality through the attachment of chiral acids or chiral alcohols to the iodine centers by ligand exchange or are achieved by the introduction of axial chirality through the iodoarene backbone. A series of chiral iodine reagents are documented below (Scheme 1). In many cases chiral I(I) reagents get oxidized in situ to the hypervalent I(III) reagents and/or these chiral I(III)/I(V) reagents are used in a catalytic amount in the presence of an external oxidant. The use of catalytic chiral hypervalent iodine reagents in asymmetric catalysis is one of the most challenging ongoing topics and this review will focus on the development of various chiral hypervalent iodine reagents and their application in typical organic transformations.

Review Asymmetric oxidation of sulfides
Pribam was the first to use chiral iodine reagents [23]. After a long time without further developments in this direction, Imamoto et al. introduced a new class of chiral hypervalent iodine reagents 1 obtained by the reaction of iodosylbenzene with various derivatives of L-tartaric acid anhydrides in 1986. A promising asymmetric induction was achieved for the oxidation of sulfides 23 to sulfoxides 24. This marked the beginning of an era of asymmetric oxidation of sulfides. However, the presence of C 2 symmetry in the chiral unit is essential to obtain decent enantioselectivity [24]. Later, Kita et al. used chiral tartaric acid derivatives to synthesize chiral I(V) reagents 2 from PhIO 2 . This represented the first example of the catalytic use of chiral hypervalent reagents in the oxidation of sulfides to sulfoxides with decent enantioselectivities (ees, Scheme 2a). The asymmetric oxidations were examined in 20 mol % cetyltrimethylammonium bromide (CTAB) reversed micelles [25]. Interestingly, Varvoglis et al. synthesized another new class of a chiral reagent 3 using (+)-camphor sulfonic acids as the source of chirality [26] which was used by Chen et al. for the oxidation of sulfides to sulfoxides with good yields but with poor enantioselectivity (Scheme 2b) [27]. Later, Zhdankin et al. synthesized different classes of chiral I(V) reagents 4 based on various amino acids as sources of chirality. The oxidation of the readily available 2-iodobenzamides (synthesized from amino acid derivatives) with potassium bromate or Oxone (2KHSO 5 /KHSO 4 / K 2 SO 4 ) efficiently delivered the I(V) reagents 4 (Scheme 2c) [28,29]. Although good product yields were obtained for the oxidation of sulfides, the ees were very low.
New classes of chiral hypervalent iodine reagents were obtained by the introduction of chiral alcohols directly to the iodine reagent through ligand exchange. Koser et al. used (+)-or (−)-menthol as a source of chirality during their synthesis of the new chiral iodine reagent 5 [30]. Chiral sulfoxides 24 (having R 1 = p-Tol, t-Bu, Bn and R 2 = Me) were obtained for the first time with excellent enantioselectivity (Scheme 2d). Another class of chiral I(V) reagents 6 was synthesized by Wirth et al. who synthesized the desired compounds through esterification between chiral alcohols and the I(I)-substituted aromatic acids followed by oxidation with dimethyldioxirane (Scheme 2e) [31]. A summary of chiral hypervalent iodine reagents used in the asymmetric oxidation of sulfides is sketched below (Scheme 2).

Asymmetric oxidative dearomatization, alkene functionalization and rearrangement strategy Oxidative dearomatization
Asymmetric oxidative dearomatizations and the use of dearomatized products to generate chiral complex molecular scaffolds in a short and efficient way is one of the attractive strategies used in chiral hypervalent iodine chemistry. Kita et al. for the first time developed a new chiral I(III) catalyst 7 having a rigid spirocyclic backbone. They applied it for the enantioselective oxidative dearomatization of phenolic derivatives 25 (spirolactonization) which is known as Kita oxidation to yield spirocyclic compounds 26 with good enantioselectivity [32]. The indication of an associative mechanism was also confirmed due to an increased enantioselectivity observed in polar solvents. Further, they were able to improve the enantioselectivity by implying steric effects at the ortho/ortho′ (R = Et in 7) positions of the aromatics (Scheme 3) [33]. The regeneration of the catalyst was achieved by m-CPBA converting iodine compound 7′ to chiral catalyst 7. The authors predicted a plausible mechanism and transition-state model 27 for the formation of the major isomer through the attack of the carboxylic acid group to the ipso position of the naphthol ring from the less sterically hindered Re-face of the substrate 25. It is worth mentioning that very recently they have introduced a new kind of binaphthylbased chiral I(III) prereagent 19 with the 8 and 8′ positions of the naphthalene substituents being occupied by iodide. Here they have observed that this chiral hypervalent iodine reagent 19 in the presence of co-oxidant m-CBPA is very useful for the dearomatizing spirocyclization of naphthol carboxylic acid [34].
Later Birman et al. reported a new variation of a chiral I(V) reagent, namely 2-(o-iodoxyphenyl)oxazoline derivative 28 [35]. The reagent was applied to an asymmetric [4 + 2] Diels-Alder dimerization of phenolic derivatives 29 to construct tricyclic derivatives 30 with moderate enantiose-Scheme 1: An overview of different chiral iodine reagents or precursors thereof. lectivity (Scheme 4). Although modest ees were obtained, this chiral oxazoline-based compound demonstrated encouraging potential as a new class of chiral hypervalent iodine reagent.
Fujita et al. synthesized non C 2 -symmetric chiral iodoarene reagents 9a derived from lactic acid derivatives and utilized them in stoichiometric fashion for the synthesis of chiral tetrahydrofuran derivatives [36]. A major breakthrough was achieved in this field by the discovery of a family of conformationally flexible C 2 -symmetric chiral iodoarene reagents. Ishihara et al. thoughtfully designed a new class of C 2 -symmetric chiral iodoarene precatalyst 8a using (−)-ethyl lactate as a chiral linker with the aromatics attached followed by its successful conversion to the amide derivative to generate precatalyst 8a [37,38]. Application of this precatalyst 8a was employed for the Kita oxidation [32] with a high level of enantioselectivity. Naphthol derivatives 31 were converted to spirocyclic lactones Later, this dearomatization strategy was further reinvestigated by the Ishihara group using a new chiral iodine precatalyst 10 derived from a chiral 2-aminoalcohol [39]. Its application in the oxidative dearomatization of phenol 33 and the subsequent reaction of the so-obtained dienes 34 with different dienophiles furnished Diels-Alder adducts 35 with excellent enantioselectivity. Intramolecular H-bonding and the presence of an achiral alcohol as additive helped them to achieve outstanding enantioselectivity (up to 99%) even when using very low catalyst loadings (1-10 mol %, Scheme 6) Ciufolini et al. further carefully modified precatalyst 10 to generate a new chiral iodine precatalyst 11 [40]. They critically altered the chiral center next to the amide NH group to achieve These were applied for the hydroxylative dearomatization of phenolic derivatives 42 followed by the successive use of the hydroxylated products as dienes in [4 + 2] cycloaddition reactions [42]. This new reagent promoted oxygen transfer in phenol dearomatization, leading to the formation of cyclodimerization products 43 with high enantioselectivity (up to 94% ee, Scheme 8 lower part).

Alkene functionalization
Nearly simultaneously to Ishihara's work, Fujita et al. reported on the modification of their previously synthesized non C 2 -symmetric reagent 9a to obtain a C 2 -symmetric chiral iodoarene reagent 9b having an ester end group instead of an amide (as in case of Ishihara's work). The enantioselective oxylactonization was achieved efficiently using stoichiometric amounts of chiral reagent 9b (Scheme 9). This lactate-derived I(III) reagent 9b was used successively for the synthesis of δ-lactones 45 in a highly stereoselective manner starting from 44 [43]. The formation of cyclic iodonium 46 is the vital part of this difunctionalization process.
Wirth et al. were the first to introduce asymmetric dioxytosylation of styrene (47) using a new class of chiral hypervalent iodine reagents 49-52 to furnish 48 with moderate enantioselectivity (Scheme 10) [44][45][46][47]. Their constant efforts towards alkene dioxygenation helped them to discover new chiral hypervalent iodine reagents and also to reach up to 65% enantioselectivity using 52.
Fujita et al. further explored the difunctionalization strategy for the development of diacetoxylation of alkenes following a Prevost and Woodward reaction [48]. Recently, the same group used chiral iodine reagent 55 together with acid co-reagent for the intramolecular oxyarylation and aminoarylation of alkenes 53 to produce 54 (Scheme 11). The presence of a silyloxy group is essential to achieve high enantioselectivity in case of the oxyarylation [49]. The Lewis acid activates the hypervalent chiral iodine reagent and then adds to the alkene system. The nucleophilic addition of the internal oxy/amino group followed by the nucleophilic addition of the aryl group delivers the desired products 54. The key to success also lies on the enantiotopic face discrimination of the alkene by the lactate-based chiral iodine reagent.  [54]. On the other hand the anchimeric assistance via participation of the amide carbonyl group (intermediate 74) dictated the formation of 1,2-difluorinated products 75 and catalyst 76 was identified as the optimal catalyst for this transformation. The 1,2-difluorinated products 75 can also be obtained with high diastereoselectivity by an anchimeric assistance of an o-NO 2 group present in the aryl ring [55]. The authors cleverly replaced the o-NO 2 -substituent with a CO 2 R group (R = H or Me). With this modification they were able to obtain fluorolactonization products with high enantioselectivity using 79 as a catalyst, via the intramolecular displacement of the aryl iodide by the CO 2 R group in 77 leading to chiral lactones of type 78 [56].

Asymmetric α-functionalization strategy
Methods for carbonyl α-functionalizations are still considered as highly demandable in synthetic organic chemistry. In this regard transition metals have been successfully applied and even allow accomplishing such transformations asymmetrically. On the other hand, diaryliodonium salts are known to transfer aryl groups ultimately leading to α-arylated products. This part of the review focuses on the development of α-functionalization strategies based on chiral diaryliodonium reagents having either an axially chiral backbone or that can be considered analogous to the C 2 -symmetric iodoarene moiety. For this purpose various chiral iodine reagents were synthesized having an axially chiral biaryl backbone. In this part, we mainly focused on the transformations using chiral iodine reagents instead of achiral iodine reagents in a combination with other chiral sources [61].
More than one century after Pribam discovered diphenyliodonium tartrate [23], Ochiai et al. realized the introduction of chirality through incorporation of binaphthyl backbones [62] and they synthesized new classes of chiral hypervalent iodine reagents 15. Later, to ensure asymmetric transformations, the same group developed the synthesis of more effective chiral iodonium salts 16 which were used for the α-arylation of β-ketoester 86 to deliver α-arylated β-ketoesters 87 with moderate enantioselectivity (Scheme 17) [63]. This was the first example of an asymmetric α-arylation of β-ketoesters using hypervalent iodine reagents. A more reactive organostannane derived Sn-I(III) exchange in the presence of BF 3 ·Et 2 O was the crucial step in the synthesis of the chiral iodonium salts from 88. In 1997, Wirth et al. for the first time reported an asymmetric α-oxytosylation of propiophenone using hypervalent iodine reagents 49/50 [45]. Later they improved the enantioselectivity by a structurally modified catalyst 51 to obtain up to 28% ee [46]. After a further few years, in 2001, they came up with a modified catalyst 52 which allowed them to reach up to 40% ee [47]. A catalytic variant of this methodology was developed by the same group using m-CPBA as co-oxidant together with catalyst 89 to get up to 39% ee [66]  family of chiral hypervalent iodine catalyst 21 with up to 46% ee [67]. The investigation of the reaction mechanisms revealed that the steric crowding around the iodine center improves the enantioselectivity (Scheme 18).
Ishihara et al. appealingly reported an oxidative cycloetherification of ketophenols 92 in the presence of an in situ generated chiral quaternary ammonium (hypo)iodite salt 94, with hydrogen peroxide as an oxidant to deliver chiral dihydrobenzofuran derivatives 93 as α-functionalized products of ketophenols 92 (Scheme 20) [69]. The substituents at the 3,3′-position of the binaphthyl moiety of the salt 94 played a crucial role to achieve high enantioselectivities up to 96%. lyst 12 to obtain spirofurooxindole derivatives with high enantioselectivity through cascade cross-coupling sequences [71].
Latterly, Masson et al. reported a new chiral iodoarene prereagent 22 which they have used for the direct oxygenation of carbonyls 98. They were able to get α-sulfonyls and α-phosphoryl oxyketones 99 with moderate ees (Scheme 22) [72]. A new type of non C 2 -symmetric chiral hypervalent reagent was utilized for the asymmetric α-oxygenation of carbonyls. Nucleophilic attack of the oxygen nucleophile to the intermediate 100 or alternatively a reaction pathway through O-enolate intermediate 101 can explain the desired product formation.
In 2014, Kita and Shibata reported a catalytic, enantioselective, nucleophilic fluorinating technique of β-keto esters 102 using 106/HF/m-CPBA as a catalytic system to access fluorinated β-keto esters 103 with moderate enantioselectivity [73]. β-Keto esters having sterically hindered adamantyl or menthyl groups lead to good selectivity. However, no further enhancement of ee could be achieved even by using a 50 mol % catalyst loading. A nucleophilic attack of the fluoride ion to the intermediate 104 or a possible ligand coupling pathway via 105 could justify the product formation (Scheme 23).
Waser et al. developed an asymmetric alkynylation of β-ketoesters and amides 107 catalyzed by a phase-transfer catalyst [74]. Their previous findings on the same reaction using a Cinchona-based phase-transfer catalyst [75] was further improved by using Maruoka's binaphthyl-derived ammonium salt 110. Pouységu and Quideau et al. prepared new axially chiral biaryl I(III) reagents 18 assembled with alkynyl ligands. They were able to achieve alkynylation of β-ketoesters 114 as well as dearomative alkynylation of phenolic derivatives 118 to obtain derivatives 115 and 119, respectively, with decent enantioselectivity (Scheme 25) [77]. The formation of an alkylidene carbene 117 and its rapid rearrangement via 1,2-silyl shift (in case of R = silyl group) into the alkylated β-ketoesters 115 can fairly explain the reaction outcome. On the other hand, the ligand exchange/coupling sequence through the iodosyl intermediate 116 can be an alternative pathway for the formation of 115. Likewise, a C-C ipso-allyl ligand coupling via intermediate 120 from O-naphtholate 118 explains the formation of product 119.

Conclusion
To conclude, throughout this review we have seen substantial growth in the field of chiral hypervalent iodine reagents. This review points a number of striking chiral hypervalent iodine reagents used in stoichiometric or in catalytic fashion for quite a number of useful organic transformations. Most importantly the oxidative chemistry can be done using catalytic amounts of chiral hypervalent iodine reagents in the presence of an external oxidant. For convenient reading, we have only highlighted the optimized chiral catalysts or reagents used in the mentioned transformations. We hope that these new classes of reagents can achieve synthetically more challenging and application-oriented conversions that can be applied for the total synthesis of natural products as well as in industry related to pharmaceutical and medicinal chemistry.
These environmentally friendly, cheap and readily available reagents will surely attract the attention of scientists towards a sustainable replacement of transition metals. The application of chiral hypervalent iodine reagents is expected to pave the way for new reactions and reagent design in the field of asymmetric synthesis and catalysis.