Efficient [(NHC)Au(NTf2)]-catalyzed hydrohydrazidation of terminal and internal alkynes

The efficient hydrohydrazidation of terminal (6a–r, 18 examples, 0.1–0.2 mol % [(NHC)Au(NTf2)], T = 60 °C) and internal alkynes (7a–j, 10 examples, 0.2–0.5 mol % [(NHC)Au(NTf2)], T = 60–80 °C) utilizing a complex with a sterically demanding bispentiptycenyl-substituted NHC ligand and the benign reaction solvent anisole, is reported.

Recently, the hydrohydrazidation of substituted phenylacetylenes using [(Ph 3 P)Au(NTf 2 )] as the catalyst was reported by Rassadin, Kukushkin et al. [42]. Catalyst loadings of 6 mol % at 60 °C were required to obtain the respective addition product in yields of 66-93%. Internal alkynes were much less reactive and even at 12 mol % catalyst loading the reaction of 3-hexyne and PhCONHNH 2 yielded the respective addition product in only 32% yield, with diphenylacetylene only 12% of the addition product were obtained. We recently reported the excellent activity of the very bulky bispentiptycenyl-substituted (NHC)Au complexes in the hydration of terminal and internal  alkynes [43] as well as in other transition-metal-catalyzed transformations [44,45]. We were now interested, whether catalysts with such ligands also display high activities in other gold-catalyzed reactions.
Solvent screening: Among the solvents tested in the previous study by Rassadin, Kukushkin et al., chlorobenzene was found to be the best solvent concerning the catalytic activity [42]. However, according to the CHEM21 consortium chlorobenzene is a problematic solvent, whose use should be avoided [47]. We therefore performed an extensive solvent screening focusing on "greener" solvents for the reactions of benzohydrazide with either phenylacetylene or 4-methoxyphenylacetylene (Table 1). It was found that the catalytic performance in anisole was comparable to that in chlorobenzene. According to both the CHEM21 consortium and the GSK solvent sustainability guide the use of anisole is highly favorable [48]. To clarify the role of chlorobenzene and anisole, most substrate screening reactions were performed in both solvents (see also Scheme 3 and Scheme 4) and based on this the use of anisole as a reaction solvent could be recommended.

Reaction time vs catalyst loading:
In order to optimize catalyst loading and reaction times the hydrohydrazidation of phenylacetylene was carried out at successively lower catalyst loading ( Table 2). The obvious consequence being a decrease in the substrate conversion.
This, however, could be compensated to some extent by longer reaction times. Based on this observation catalyst decomposition appeared to be negligible and it seemed, that the role of gold is primarily that of a Lewis acid activating the alkyne. Consequently, even at 0.05 mol % catalyst loading virtually
Most hydrohydrazidation reactions showed nearly quantitative product conversion to 6 and provided isolated yields in excess of 90% using as little as 0.1-0.2 mol % of complex 1. Just like in related reactions, the nucleophile exclusively added to the β-carbon of the triple bond. A single substituent in the orthoposition of the alkyne did not exert a strong steric effect. Even the hydrohydrazidation of the sterically highly demanding 2,4,6-triisopropylphenylacetylene provided 82% isolated yield based on 90% substrate conversion (Scheme 3, compound 6i).
There was a pronounced electronic effect and electron-rich arylalkynes reacted faster than those with electron-withdrawing groups. The products derived from benzohydrazides with electron-rich aromatic groups tended to be somewhat unstable during chromatographic purification (6j, 6q). In such cases it is advisable to facilitate product purification by choosing modified reaction conditions (e.g., higher catalyst loading or longer reaction times), to ensure virtually quantitative product formation.

Hydrohydrazidation of internal alkynes:
Previously, internal alkynes could not be converted efficiently into the respective hydrohydrazidation products via gold catalysis [42], while product formation was claimed in a thermal reaction [49]. However, in the presence of complex 1 internal alkynes provided the respective addition products 7 in excellent yields using catalyst loadings in the 0.2-0.5 mol % range at slightly elevated temperature (T = 60-80 °C, Scheme 4). A range of dialkyl-, alkyl-, aryl-, and diarylacetylenes was reacted with electronically variable benzohydrazides (4-R = NMe 2 , H, NO 2 ), to cover a range of steric and electronic substituents. In case shorter reaction times were desired, this could be compensated by increasing the amount of catalyst or the reaction temperature. The order of the alkyne reactivity in the present study was as follows: RCCH > alkyl-CC-alkyl > aryl-CC-alkyl ≥ aryl-CC-aryl.

Scheme 4:
Hydrohydrazidation of internal alkynes in chlorobenzene and anisole using complex 1. Reaction temperature was 60 °C unless otherwise noted (first line solvent chlorobenzene, second line solvent anisole: catalyst loading, reaction time, conversion % (isolated yield %). a 80 °C reaction temperature; b isolated yield after 1 w; c isomeric ratio determined via NMR spectroscopy.
Disubstituted acetylenes with different substituents tended to produce isomers in the hydrohydrazidation reaction (Scheme 4, products 7b, c, d, i, and j). No preference for either isomer was observed -not even when using aryl-, alkylacetylenes, or electronically different aryl groups in tolanes. However, the steric bulk of a single methyl group in 2-methyltolane led to the selective formation of the single addition product 7h, but even such sterically hindered tolanes (synthesized via Sonogashira coupling) [50] show reasonable substrate conversion. To assess the electronic effect of substituents on the hydrazide-substituted RC 6 H 4 -CONHNH 2 relatives (R= NMe 2 , NO 2 ) were tested leading to 7f and 7g. With a view to the larger distance of the functional group from the reactive center, the electronic effect was weaker, but nonetheless the conversion of the electron-deficient hydrazides (R = NO 2 ) was slightly more efficient than with the electron-rich hydrazides (R = NMe 2 ).

Conclusion
In conclusion, we have demonstrated the efficient hydrohydrazidation of various terminal and internal alkynes utilizing the bispentiptycenyl-substituted [(NHC)Au(NTf 2 )] complex 1 using catalyst loadings between 0.1-0.5 mol % at temperatures between 60-80 °C in chlorobenzene, or anisole as a green reaction solvent.

Experimental
All reagents were obtained from commercial providers (Sigma-Aldrich, Alfa Aesar, TCI Europe) and were used without further purification. All solvents were dried over CaH 2 and distilled. All screening reactions were performed in Schlenk tubes under normal atmosphere unless otherwise noted. 1  General procedure for the hydrohydrazidation of alkynes.
In a small Schlenk flask equipped with a small stirring bar the corresponding alkyne (0.5 mmol) and the corresponding benzhydrazide (0.5 mmol) were mixed with anisole or chlorobenzene (2 mL). For the internal standard mesitylene (69 µL, 0.5 mmol) was added. A stock solution of the corresponding gold-triflimide catalyst (0.005 M in anisole or chlorobenzene, 200 µL, 0.001 mmol, 0.2 mol %) was introduced to the mixture. The reaction mixture was stirred at 60 °C or 80 °C for the respective time and the progress of the reaction was monitored by GC. After the reaction was completed, the solvent was removed in vacuo and the residue triturated in pentane. Column chromatography (DCM/ethyl acetate 5:1) afforded the respective benzohydrazone in good to excellent yields.

Supporting Information
Supporting Information File 1 Characterization data and copies of NMR spectra and mass spectrometric data.