Synthesis of organic liquid crystals containing selectively fluorinated cyclopropanes

This paper describes the synthesis of a series of organic liquid crystals (LCs) containing selectively fluorinated cyclopropanes at their termini. The syntheses used difluorocarbene additions to olefin precursors, an approach which proved straightforward such that these liquid crystal candidates could be efficiently prepared. Their physical and thermodynamic properties were evaluated and depending on individual structures, they either displayed positive or negative dielectric anisotropy. The study gives some guidance into effective structure–property relationships for the design of LCs containing selectively fluorinated cyclopropane motifs.


Introduction
Display materials associated with modern electronic devices such as personal mobile phones and TV sets, have changed dramatically in the past decades as liquid crystal display (LCD) technology has evolved [1,2]. A key challenge is to make suitable liquid crystalline (LC) materials that satisfy the requirements for different LCD technologies. For the traditional twisted nematic (TN) LCD technology, devices require liquid crystals with display positive dielectric anisotropy by which the molecular dipole moment is oriented parallel to the long axis of the molecule, while for the current vertical alignment (VA) LCD technology, liquid crystals with negative dielectric anisotropy are required [3]. Fluorine, as the most electronegative atom, forms stable bonds to carbon and can thus induce polarity. It is also attractive as a design feature due to the low polarizability of the C-F bond relative to other polar substituents such as nitrile and ester groups, and this reduces intermo- lecular interactions leading to lower viscosities and thus increased life time reliability [4,5]. A significant effort has been devoted to the development of liquid crystals with either positive or negative dielectric anisotropy by introducing the C-F bond or the dipole of a CF 2 group either parallel or perpendicular to the long molecular axis. For example, in the area of negative liquid crystalline materials, Kirsch et al. have reported the synthesis of bicyclohexane and bis(cyclohexyl)ethane liquid crystals which contain axial fluorine substituents (Figure 1, 1  and 2), however, due to the propensity for HF elimination from these molecules over time, these liquid crystals have not been adopted as commercial products [6,7]. 2,3-Difluoroaryl motifs such as 3 have proven to be a successful class of negative dielectric anisotropic liquid crystals and the more rigid 1,1,6,7tetrafluoroindane 4 led to an enhanced polarity and improved negative dielectric anisotropy character [8]. Other liquid crystals of this class are the recently reported fluorinated cyclohexane 5 and 1,1,2,2-tetrafluorocyclohexane 6 [9,10], but the complexity of their synthesis has limited their development as practical materials.
As a consequence, it continues to be a research objective to introduce polar substituents in a manner that can influence the nature of the dielectric anisotropy of the resultant material. In this context we explore the cyclopropane motif containing fluorine atoms. Selectively fluorinated cyclopropanes have been widely used in pharmaceutical research [11], however, the introduction of fluorinated cyclopropanes into liquid crystal scaffolds has not received much attention. Haufe et al. [12], reported enantiomerically pure fluorinated diphenylcyclopropane carboxylates as potential chiral dopants to induce a cholesteric phase, but this was not extended to the exploration of positive or negative dielectrics. Recently, we reported the efficient synthesis of α,β,β-trifluorocyclopropanes 7 (Figure 2) through difluorocarbene addition to alpha-fluorostyrenes [13]. This used the extraordinary useful method for the generation of difluorocarbene from the Ruppert-Prakash (TMSCF 3 ) reagent [14]. DFT analysis suggests the lowest energy conformer of aryl α,β,β-trifluorocyclopropane 7 orients the C-F bond perpendicular to the aryl ring. So, if the α,β,β-trifluorocyclopropane motif were introduced into an appropriate LC scaffold, it could reasonably induce negative dielectric anisotropy if the dipole associated with the cyclopropane remains oriented perpendicular to the molecular axis. Based on this idea, we report the design and synthesis of cyclopropanes 8 and 9 with an objective to assess their LC properties. Cyclopropane 8 with a single CF 2 group offered a control to assess the influence of the alphafluorine atom in cyclopropane 9 containing three fluorines. In order to extend the study to explore other selectively fluorinated cyclopropane motifs we set out to prepare liquid crystal candidates 10 and isomers 11a and 11b. Ether 10 should have significant rotational freedom due to rotation around the ether bonds and will be compared with isomers 11a and 11b which are much more conformationally constrained ( Figure 2). Therefore, the aim of the study was to prepare these target liquid crystals and evaluate their properties relative to each other, to establish if there were any obvious structure-activity relationships to emerge for the design of positive or negative dielectric materials. Also the fixed spiro CF 2 -containing cyclo- propanes 11a and 11b became targets to assess the impact of a configurationally rigid bicyclic motif. It is relatively obvious that for each of these isomers the CF 2 dipole in each cyclopropane is orientated either along the molecular axis (for 11a) or perpendicular to the molecular axis (for 11b), and these were anticipated at the outset to give positive and negative dielectric anisotropy values, respectively.
The synthesis of trifluorocyclopropane 9 is shown in Scheme 2. Compound 9 was prepared through bromofluorination of 12, followed by base-induced HBr elimination [15], and then difluorocarbene addition to generate 9. The starting olefin 12 was exposed to an excess of N-bromosuccinimide (NBS) and HF·Py to generate 13a and 13b as a mixture of regioisomers in a ratio of 4:1. There was no requirement to separate these isomers at this stage. Subsequent addition of potassium tert-butoxide into a mixture of 13a and 13b in dichloromethane (DCM) resulted in an efficient elimination to generate vinyl fluoride 14 as a major product. Vinyl fluoride 14 was purified by column chromatography in a 42% yield over the two steps. Finally, difluorocarbenene (:CF 2 ) addition using the TMSCF 3 /NaI protocol was used to generate the target product 9 in 46% yield.
The preparation of cyclopropyl ether 10 was accomplished as illustrated in Scheme 3. Reduction of cyclohexanone 15 with NaBH 4 gave cyclohexanol 16 in a ratio of 2:1. The major trans product 16a was purified as a single entity by column chromatography and was isolated in 45% yield. Vinyl ether 17 could be efficiently prepared using the methodology developed by Bosch [16]. Accordingly, treatment of 16a with butyl vinyl ether, bathophenanthroline (BPhen) and Et 3 N, using palladium(II) trifluoroacetate as a catalyst, gave vinyl ether 17 in 62% yield in a single step. Finally, difluorocarbene-mediated difluorocyclopropanation generated 10 in 50% yield.
phosphine which was generated in situ from methyltriphenylphosphonium bromide (PPh 3 CH 3 Br), generated exo-methylene cyclohexane 18 in a very straightforward manner, and the product could be isolated by chromatography in 72% yield [17]. This olefin was then subject to a difluorocarbene cyclopropanation using TMSCF 3 and NaI, and this generated both isomers, 11a and 11b, in a ratio of 5:1, respectively. After three recrystallizations, the major isomer 11a could be isolated as a single stereoisomer. It proved impossible to isolate a sample of isomer 11b without a significant and dominant contamination with 11a. Thus, it was with some frustration that we were unable to prepare a suitable sample, both in quantity and purity, of isomer 11b for subsequent analysis. Stereoisomer 11a was a crystalline solid and a suitable crystal was subject to X-ray structure analysis and the structure is shown in Scheme 4. In this way the stereochemistry of 11a and 11b could be confirmed unambiguously.

Evaluation of liquid crystal candidates 8-11a
With the four difluorocyclopropanes 8-11a in hand, our attention focused on an experimental evaluation of their thermodynamic and physical properties, such as birefringence (Δn) and dielectric anisotropy (Δε). DSC and POM analysis (Table 1) indicated that only compounds 8 and 9 exhibited smectic phases. The smectic phase of LC 8 was maintained over a broad temperature range (54-84 °C), whereas that for 10 and 11a only showed a melting point and these compounds did not display any obvious liquid crystallinity (Table 1). Therefore, any development of these latter materials would require extended core structures to enhance their LC potential.  The birefringence Δn (Table 2) for compounds 8-11a was measured (Abbe refractometer). In all cases the Δn values were low, which is entirely consistent with their core aliphatic structures, unlike materials with aromatic rings. The differences for Δn for 8, 9 and 10, were found to be small, whereas the spirocyclopropane 11a had a significantly, decreased Δn. As discussed, either positive or negative dielectric anisotropy is an important parameter related to the driving voltage of LC displays and in order to reduce energy consumption, good materials should induce a large value for dielectric anisotropy. Compounds 8 and 9 were found to exhibit the expected negative Δε values, however, the overall polarity is low (8 = −0.5, 9 = −0.2). This is presumably due to the ability of the C-C bond attached to cyclopropane to rotate, and thus the compound will adopt conformations with low overall molecular polarities. A comparison of the Δε for 8 and 9 illustrates that incorporation of the third alpha-fluorine lowers the overall Δε value. This is presum- ably due to a resulting decrease in the overall molecular dipole moment ( ) along the minor axis. When an ether was used as the linkage in compound 10, the compound becomes more flexible and, perhaps surprisingly, the overall Δε parameter became more positive. Clearly the effect of introducing a C-O bond renders this molecule dissimilar from the others in this series. However, changing the core aliphatic structure to the more rigid spiro structure 11a, brought about a dramatic enhancement of the molecular dipole moment (μ || ), resulting in a much more positive and increased parameter value (Δε = 4.8). This experimental value was close to the predicted calculated value (Δε = 4.3) as shown in Table 2. It is clear that there is an advantage in a rigid structure for imparting a maximum polarity. As stated above, we were unable to obtain a stereochemically pure sample of diastereoisomer 11b, free from 11a, however, theory indicates that 11b should display negative dielectric anisotropy, although the magnitude of the parameter was relatively low (Δε = −1.1). Thus the two isomers constitute two different classes of LC materials, entirely as a consequence of stereochemistry.
The best compound of this series is 11a and it was of interest to get some insight into its conformational flexibility. Thus, a conformational analysis of 11a (and 11b) was conducted computationally (ωB97X-D/6-311+G(2d,p)//ωB97X-D/6-31G(d) + ZPE level (see Supporting Information File 1)). There are many potential low energy conformations arising from alkyl side chain C-C bond rotations which would not be anticipated to change the overall properties significantly, however, we were interested in assessing the energy required for the bispirocyclohexane ring to adopt an axial rather than the lower energy equatorial arrangement. For 11a, the lowest energy conformer found was a rotamer around the central C-C bond linking the cyclohexane rings, but an essentially isoenergetic conformer is that found in the X-ray crystal structure. The first conformers where the terminal bispirocyclohexane ring lies axial are significantly higher in energy (ΔG = +1.25 kcal/mol −1 and ΔG = +1.19 kcal/mol −1 ) than the equatorial conformers as illustrated in Figure 3. Notably for both the axial and equatorial conformers, the orientation of the CF 2 group, and therefore its dipole, remains perpendicular to the long molecular axis (requirement for +ve dielectric). A similar result was obtained for stereoisomer 11b (see Supporting Information File 1) again with the first axial conformer at ΔG = +1.14 kcal/mol −1 above the ground state equatorial conformer. In this case the orientation of the CF 2 group, and therefore the dipole, remains perpendicular to the long molecular axis (requirement for −ve dielectric) for both the axial and equatorial conformers. This analysis, and that of the X-ray structure, suggests that the equatorial conformers will dominate in condensed phases, and that the overall molecular dipoles will not be compromised by minor contributions of axial conformers.

Conclusion
In conclusion, a series of candidate liquid crystals 8-11a with difluorocyclopropane motifs at their termini were prepared in a straightforward manner. In all cases the cyclopropane was introduced by difluorocarbene addition to an olefin, the difluorocar-bene being generated from TMSCF 3 /NaI. An evaluation of the physical properties of LC candidates 8-11a revealed that LC's 8 and 9 exhibited smectic phases with low levels of negative dielectric anisotropy. The relatively high positive dielectric anisotropy of compound 11a indicates that the configurational constrained motif is required to increase the magnitude of the Δε parameter. Although it proved challenging to isolate a stereochemically clean sample of isomer 11b for experimental evaluation, theory predicts that it will have a modest negative dielectric value, indicating the importance of stereochemistry in dictating the class of LC material. We conclude too that the overall performance of prototype LCs 11a and 11b should not be compromised by conformational flexibility. Although none of the compounds prepared here met all of the criteria for commercial development, the study gives an insight into the potential for this novel difluorocyclopropane motif in liquid crystal design and development.