Beilstein Journal of Organic Chemistry Beilstein Journal of Organic Chemistry Beilstein Journal of Organic Chemistry Part 2. Mechanistic Aspects of the Reduction of S-alkyl-thionocarbonates in the Presence of Triethylborane and Air

Experiments conducted with deuterated compounds demonstrated that during the reduction of S-alkylxanthates with triethylborane, the hydrogen atom transferred has several competing origins. Hydrogen abstraction from water (or an alcohol) is the most favourable route.


Background
In the first part of this series, [1] we showed that trialkylboranes and especially commercial solutions of Et 3 B are efficient reducing agents that permit the conversion, at room temperature, of S-alkylxanthates, iodides and Oalkylxanthates into the corresponding alkanes with good to excellent yields. Such a process complies with the longstanding pursuit of an environmentally acceptable process for desulfurisation, dehalogenation or deoxygenation that operates under mild reaction conditions. In this context, special attention must be paid to a paper published by Jaszberenyi and Barton in 1990. [2] The authors described a reduction process of O-alkylxanthate and related compounds with Bu 3 SnH/Et 3 B/air at room temperature. They mentioned very briefly that when Bu 3 SnH was omitted, the reduction still occurred. The O-cyclododecyl S-methylxanthate derived from cyclododecanol afforded cyclododecane in a remarkable 62% yield. No hypothesis about the origin of the hydrogen atom that replaced the original xanthate function was proposed. Recently, as the work reported here was largely completed as already mentioned in the first part of this series, [3,4] Wood and coworkers also observed an "anomalous" reduction of a closely related tertiary O-alkylxanthate into the corresponding alkane instead of an expected rearrangement. [5] In a subsequent report on the reduction of B-alkylcatecholboranes, Renaud and coworkers showed that the O-H bond in methanol may also be the source of hydrogen. However, the deuterium incorporations in experiments aimed at elucidating the mechanism are relatively low, [6] and obviously the experimental results do not support the hypothesis that the O-H group is the sole source of the hydrogen transferred.

Results and discussion
In this Note, we wish to report our findings concerning the intriguing question of the origin of the hydrogen atom that replaces the radicophilic group in the reduction of Salkyl-thionocarbonates. Several hypotheses may reasonably be proposed. The first possibility is a hydrogen transfer from the solvent. However, dichloromethane, 1,2-dichloroethane and hexane (from the commercial solution of Et 3 B) utilised in the preceding article, [3] are considered to be poor hydrogen atom donors, especially at low temperature. [7] There are only rare reports concerning the ability of an alkane (cyclohexane) to cleanly transfer a hydrogen atom to a specific type of carbon radical. [8,9] Disproportionation between the ethyl radical and the carbon-cen-tred radical derived from the xanthate would have probably given the corresponding olefins, especially in the case of a tertiary radical. Such olefins were never found. A more seemly hypothesis is a hydrogen abstraction from the α-position of the boron atom. This reaction is well documented and energetically acceptable (BDE (C-H) = 80 ± 3 Kcal/mol). For example, the methyl radical abstracts α-boronyl hydrogen of Et 3 B 124 times faster than hydrogen in the methyl group of toluene. [10] We also envisioned the possible intermediacy of a transient organoborane species that would undergo protonolysis during work-up. However, a "simple" trialkylborane intermediate is not a plausible route since the attack of a carbon radical on the boron atom is not favourable. [10] In an attempt to gain information about the mechanism, we performed deuteration experiments ( Figure 1 and Table 1). Most of the results reported herein concern the reduction of xanthate 1a [see Additional files 2, 3, and 4]. This substrate was chosen because of its low molecular weight and its simple structure that ensure easy spectral analyses (NMR, MS, GC-MS) and also because a putative 1,5-hydrogen shift between the intermediate radical and a hydrogen atom in the α-position to the ketone cannot intervene. This point was discussed at the end of the first part of this series. [3] On the other hand, we proved that a similar 1,5-hydrogen shift in which the acetyl group would be implicated does not occur either (see below). The standard experiment (entry 1) performed without any source of deuterium serves to evaluate the natural abundance of 13 C in compound 1c and to calibrate the deuterium measurements.
A possible source of hydrogen could be an alcohol present as a contaminant in various solvents, therefore we chose to examine the effect of addition of methanol to the reaction mixture. When xanthate 1a was treated with Et3B/dry air, according to method A, [3] in a mixture of chloroformd and methanol-d4, the incorporation of deuterium was determined to be 88% (entry 2). The analysis of the spectral data (1H, 2H and 13C NMR and mass) unambiguously shows that the incorporated deuterium is located at the same position as the parent xanthate. This proves that no 1,5-hydrogen shift occurred. The replacement of chloroform-d by 1,2-dichloroethane gave similar results (85%, entry 3). More interestingly, the incorporation was still high when methanol-d4 was replaced by CH3OD (76%, entry 4). Methanol-d4 or CH3OD can be in turn replaced by D2O without significant change in the level of deuterium incorporation (entries 5 and 6), even in a solvent known to be a good hydrogen donor such as THF (entry 6). Experiments 2-6 established that, in the presence of deuterated methanol or water, the incorporated deuterium may come from rupture of an O-D bond. The results given in entries 7 and 8 show that there is no noticeable incorporation of deuterium when D2O or CH3OD are added after 3 h, a period after which all the starting material 1a has been consumed. On the other hand, experiment 9, where CH3OD was added after 20 min. before consumption of all the starting material, indicates that the deuterated compound is formed pro-rata with time of contact with CH3OD (compare entries 9 and 4). Under the same conditions, we observed that there is no more incorporation of deuterium when CH3OD was added after 30 min. (results not shown). Therefore, there is no accumulation of an intermediate species responsible for the conversion of the xanthate group into the alkane. Experiments 10, 11 and 12 prove that the incorporation of deuterium does not parallel the ratio H2O/D2O. Even small amounts of H2O led to a significant decrease of deuterium incorporation. This may be explained as the consequence of a significant isotopic effect or of an alternative mechanism in which the O-H(D) bond is not implicated. We showed that the incorporation of deuterium was uppermost in the case of tertiary xanthate 2a (entry13).
Eventually, we performed several experiments using solutions of pure Et 3 B in deuterated solvents, with or without added H 2 O or D 2 O (entries [14][15][16][17][18][19]. When chloroform-d was used as solvent, the percentage of deuterium incorporation is still high (57%, entry 14). By contrast, when the reaction is performed in benzene-d 6 , no deuterium is incorporated (entry 16). These two experiments indicate that, depending on its ability to transfer hydrogen, the solvent may also be a source of hydrogen. Finally, experiments 6, 15 and 17 show that when D 2 O is present the incorporation of deuterium is very high and thus transfer of D from D 2 O surpasses that from the other sources. Experiment 18 corroborates this conclusion: deuterium incorporation from CDCl 3 is suppressed when H 2 O is present. Noteworthy is the observation that when the reaction is performed in THF-d 8 , no deuterium incorporation occurs (entry 19).   [5] This author also came to the conclusion that water is the source of hydrogen and proposed two routes. The first one invokes an innovative concept in which water, complexed to a trialkylborane, is the hydrogen atom donor. Gaussian 3G calculations indicate that such a complexation would lower the BDE of the O-H bond by 30 Kcal/mol when compared to free H 2 O, thus rendering hydrogen abstraction from water a plausible process. The second route implies hydrogen abstraction from •O-O-H radical (O-H BDE 47.6 Kcal/mol). The latter could possibly be formed by interaction of dialkylboron peroxy radical R 2 BOO• with water and should depend on the amount of dioxygen. It is worth noting that both routes necessitate at least stoechiometric amounts of water. Wood and his colleagues [5] serendipitously observed this anomalous reduction of O-alkylxanthates, working on very small scales (0.006 mmol.). Conspicuously, in further experiments aimed at elucidating the origin of the hydrogen atom, the authors deliberately added high quantities (5 to 20 equiv.) of H 2 O or D 2 O. This mechanism is different from the process involved in the case of α-acyl xanthates where an intermediate enol boronate is a likely intermediate that can be easily prot-onolysed during work-up. When xanthate 1a was reduced with Et 3 B/air in methanol-d 4 , a mixture of compound 1b and its mono-deuterated analogue (55% deuterium incorporation, determined by 1 H NMR) was obtained. However, because of a possible deuterium-proton exchange through enolisation, this observation cannot be used to ascertain the mechanism.
The results reported in Table 1 prove that competitive radical mechanisms are operative: when water (or an alcohol) is present, the abstraction of the hydrogen atom obviously takes place by breaking an O-H bond, whereas in the absence of water, this hydrogen transfer could happen by hydrogen abstraction from the solvent (provided that it is a reasonably good hydrogen atom donor). However, despite all our efforts to operate under strictly anhydrous conditions, we observed good yield of hydrogen incorporation in experiments carried out in completely deuterated solvents (Table 1, entries 14 and 16). This suggests that no water is needed and that a third source of hydrogen atom, different from water and solvent, might be involved.
We first focused our attention on O-ethyl-S-ethyl dithiocarbonate as a possible source of hydrogen atom. This byproduct is produced by reaction of ethyl radical, generated from Et 3 B, with the xanthate function. Deuterated compounds 3-5 were easily prepared from ethanol, carbon disulfide and ethylbromide ( Figure 2). The results reported in Table 2 clearly show that no deuterium transfer is observed from either compounds 3, 4, or 5 when xanthate 1a was subjected to reduction (Method A) in the presence of one equivalent of O-ethyl-S-ethyl dithiocarbonate, using benzene as solvent to suppress any hydrogen atom transfer from the solvent.
Along the same lines, we prepared compound 1d by addition of xanthate 6 to deuterated allylacetate 7 (Figure 2). The reaction of xanthate 1d with Et 3 B (5 equiv) in benzene (Method A) afforded the corresponding reduced compound 1e. Examination of NMR and mass spectra of compounds 1d and 1e shows that during both the addition and the reduction processes no deuterium loss or scrambling occurred. In particular, a putative 1,5-hydrogen transfer between the transient radical and the CD 3 group is clearly ruled out.
Incidentally, we noticed that when the reduction of xanthate 1d (or 1a) with 5 equiv of Et 3 B was performed in benzene, the reaction was not complete even after 18 h, and much starting material was recovered (see Table 2). We therefore performed a kinetic monitoring of the reaction using a GC technique. The reduction was carried out according to showed that all the starting material was consumed. The yield of compound 1b then reached 82% (isolated yield). At this time, we cannot explain why the reduction is more sluggish in benzene than in other solvents. Noteworthy, Wood and colleagues [5] used a huge amount of Et 3 B (20-50 equiv.) when performing the reaction in benzene.
As put forth above, a hydrogen abstraction from Et 3 B is an energetically credible hypothesis. To verify this, we undertook the synthesis of Et 3 B-d 15 . After testing an improvement of a procedure published by H.C. Brown and coworkers in which Et 3 B is prepared from ethylbromide, we succeeded in obtaining Et 3 B-d 15 8 in high purity from commercially available ethylbromide-d 5 (Scheme 1). [11] The selectively deuterated compounds (CH 3 CD 2 ) 3 B 9 and (CD 3 CH 2 ) 3 B 10 were prepared in a similar fashion from CH 3 CD 2 Br and CD 3 CH 2 Br, respectively [see Additional file 1].

D 3 CCD 2 Br
Mg Diethylene glycol dibutylether Kinetics of the reduction of compound 1a in C 6 H 6 at 20°C   When xanthate 1a was reacted with perdeuterated triethylborane (5 equiv), an 8.3% incorporation of deuterium was observed in the resulting reduced compounds 1b +1c (Table 3, entry 1). This result is perfectly reproducible as shown by comparison of entries 1 and 2. When the reaction was performed in a dried Teflon round bottom flask, the incorporation increased to 26.7%. This result is also quite reproducible (entry 3 vs entry 4). We have shown above that no deuterium transfer was seen from dithiocarbonate 4, a by-product formed during the reduction of compound 1a in the presence of deuterated triethylborane. Therefore, one must assume that the deuterium transfer occurs directly from Et 3 B-d 15 to the transient carbon radical formed by fragmentation of the xanthate function in compound 1a. Interestingly, the deuterium abstraction occurs not only from the methylene group as anticipated, but also from the methyl group (entries 5 and 6). However, the abstraction from the methylene group, after statistical correction, is approximately 5.5 times more efficient than from the methyl group. Examination of Table 3 also strongly suggests that the surface of the glassware might play a role in hydrogen atom donation: substituting merely glass by Teflon brings about an increase of the deuterium incorporation by a factor of three. Conversely, when the reaction was carried out in the same Teflon flask under the same conditions as in experiments 3 and 4, but in the presence of small glass rings, the incorporation of deuterium dropped back to 8.3% (entry 7). Complexation between the O-H groups on the surface of the silica and triethylborane, analogous to that postulated between water and triethylborane, appears to be a consistent hypothesis to explain the hydrogen transfer. However, this hypothesis seems difficult to test directly as the preparation of deuterated glassware is not a straightforward process: the replacement of hydrogen by deuterium on the surface of silica requires very harsh conditions. [12,13]

Conclusion
Undeniably, the reduction of S-alkyl-thionocarbonates conceals several subtleties. In our quest for the origin of the transferred hydrogen, we demonstrated by unambiguous deuteration experiments that three types of sources are implicated. The first one relies on hydrogen donation from an O-H group (presumably complexed to the trialkylborane). This O-H group may belong to water, an alcohol, and, in all likelihood, to the surface of the glassware. We showed that, when present, water or an alcohol (methanol) is the preferred hydrogen donor. The second involves a hydrogen transfer from the solvent, as far as it constitutes an acceptable hydrogen donor. The last source is triethylborane itself. The hydrogen abstraction occurs at the α position to boron and also, to a minor extent, at the β position. It is important to note that the reduction gave good yields even under anhydrous conditions (or without alcohol). This allows extensions of this method to watersensitive compounds to be envisioned. This will be the subject of a forthcoming paper. In fact, the qualitative results reported in this article indicate that the overall reduction process seems to be the result of a delicate balance between three different elementary mechanisms.
Very recently, Newcomb, [14] following Wood's and Renaud's reports, carried out kinetic estimations of the rate of hydrogen abstraction by an alkyl radical from the complex between Et 3 B and water using the routine radical clock method. This author also came to the conclusion that hydrogen abstraction from the α position of Et 3 B must be invoked. No spectral or chemical evidence was furnished either to ascertain the formation of a complex between Et 3 B and water or to demonstrate that hydrogen abstraction from triethylborane is effective. However, it is very gratifying for us to note that this author found the same order of magnitude for the rate of the hydrogen transfer as we estimated in this paper and in the preceding part of this series. [3]  a The reaction was performed in a dry Teflon 25 mL round bottom flask. b Experiments 1-2 were carried out using the same 25 mL round bottom flask. c Same reaction conditions as in experiments 3 and 4, except that small glass rings (1 g) were introduced into the flask. All the reactions were performed using 5 equiv of triethylborane. d (CH 3 CD 2 ) 3 B 9 and (CD 3 CH 2 ) 3 B 10 were prepared from commercially available CH 3 CD 2 Br and CD 3 CH 2 Br respectively, according to the same procedure as the one described for the synthesis of perdeuterated triethylborane.
Despite a lack of experimental proof at this time, one may postulate that the reduction of O-alkylxanthates and iodides with triethylborane/air also embodies the same plurality of mechanisms. [3] The reactivity of the combination alkylborane/air/water touches many other domains and certainly deserves further study.