Pseudo five-component synthesis of 2,5-di(hetero)arylthiophenes via a one-pot Sonogashira–Glaser cyclization sequence

Based upon a consecutive one-pot Sonogashira–Glaser coupling–cyclization sequence a variety of 2,5-di(hetero)arylthiophenes were synthesized in moderate to good yields. A single Pd/Cu-catalyst system, without further catalyst addition, and easily available, stable starting materials were used, resulting in a concise and highly efficient route for the synthesis of the title compounds. This novel pseudo five-component synthesis starting from iodo(hetero)arenes is particularly suitable as a direct access to well-defined thiophene oligomers, which are of peculiar interest in materials science.


Introduction
Over the past decades 2,5-di(hetero)aryl substituted thiophenes [1,2] have constantly attracted a lot of interest, especially as charge-transport materials in electronic [3] and optoelectronic [4][5][6] devices, but also in drug design as antitumor [7] or antiinflammatory agents [8] or in plaque imaging [9].Most commonly the methodological access to these targets has been based upon Pd-or Ni-catalyzed coupling of dihalo thiophenes with organometallic (hetero)aryl derivatives by virtue of Suzuki [10] or Stille [11] coupling.Even though this strategy for the synthesis of symmetrical 2,5-diarylated thiophenes has proven to be efficient and general, all of these synthetic routes share the drawback of ultimately requiring two different halogenated (hetero)arenes and the separate conversion into an organometallic derivative in an additional step.From a practical point of view halogen-metal exchange, transmetalation and isolation occasionally turns out to be tedious and in many cases the use of polar functionality in the substrate is considerably restricted.
In recent years interesting examples of palladium-catalyzed direct C-H activation and arylation of (hetero)aromatics have been reported [12,13].Although these procedures only employ  a single halogenated substrate and avoid the stoichiometric formation of organometallic intermediates the substrate scope is limited to activated heteroaromatic C-H bonds.In addition, sophisticated catalyst systems must be applied, and the efficiency is also variable.
According to this general one-pot access to 1,4-di(hetero)aryl-1,3-butadiynes we reasoned that it should be possible to address the butadiyne functionality towards heterocyclization, again in a one-pot fashion.Here, we communicate the first pseudo fivecomponent synthesis of 2,5-di(hetero)arylthiophenes by virtue of a one-pot Sonogashira-Glaser cyclization sequence.
We first set out to identify an optimal cosolvent for all four steps taking advantage of the high yield Sonogashira-Glaser coupling synthesis [15] of 1,4-diphenylbutadiyne starting from iodobenzene (1a) (Table 1).In addition, the final cyclization step to give 2,5-diphenylthiophene (2a) was performed under microwave heating at 120 °C for a hold time of 2 h. ).As a consequence, DMF as a solvent and dielectric heating at 120 °C for 2 h in the final step were identified as the optimal settings for the sequence.
With these optimized conditions in hand, the substrate scope of this novel pseudo five-component synthesis of 2,5di(hetero)arylthiophenes was studied (Scheme 3).Starting from (hetero)aryl iodide 1 all reactions were carried out on a 2 mmol scale to give symmetrical 2,5-di(hetero)arylthiophenes 2 as stable, crystalline solids (with the exception of 2b) in moderate to good yield (Figure 1).The structural assignments of all thiophenes 2 were unambiguously supported by 1 H and 13 C NMR spectroscopy, mass spectrometry, and combustion analysis.Due to poor solubility no NMR spectra of compounds 2m, 2n and 2o could be recorded, yet, the assignment of the molecular structure is supported by mass spectrometry and combustion analysis.
Deviating from the general procedure, in the case of m-bromoiodobenzene (1d) only 1 equiv of TMSA was added in order to minimize a second alkynylation at the bromine position in the initial Sonogashira coupling step, which resulted in a moderate yield of the dibromo derivative (2d).Upon reaction of the m-iodo-nitrobenzene (1g) a concomitant reduction of the nitro groups to the amines was observed, giving rise to the dianilino thiophene 2g.
Most interestingly, even the linear five-ring-containing derivatives "PPTPP" (2n) and "T5" (2o), which are important chargetransport molecules in materials science [3], were easily accessed in a one-pot procedure.Starting from the stable and readily available aryliodides 1n and 1o, the presented new methodology allowed the synthesis of both molecules in a quick, simple and economic one-pot reaction.Moreover, the usual preparation and isolation of boronic acids or even more sensitive zinc organometallics was circumvented.In addition the use of the rather expensive diiodothiophene as a coupling partner was avoided [24][25][26]."PPTPP" (2n) and "T5" (2o) were readily purified by Soxhlet extraction.
Upon reaction of N-Boc-3-iodoindole (1p) a complete cleavage of the protection group and the formation of several byproducts were observed leading to a significantly lower isolated yield of the corresponding thiophene 2p.

Conclusion
In summary we have developed an economical and efficient one-pot sequence for transforming (hetero)aryl iodides into symmetrical 2,5-di(hetero)arylthiophenes based upon an initial sequentially Pd/Cu-catalyzed Sonogashira-Glaser process followed by a subsequent sulfide-mediated cyclization.A broad range of functional groups is tolerated and the iodo substrates are either commercially available or easily accessible.This (yields refer to 0.5 equiv of (hetero)aryl iodide).a Only one equiv of TMSA was applied in the Sonogashira step.b According to elemental analysis compound 2f was obtained with 25% hydrate.c m-Iodo nitrobenzene (1g) was applied as a starting material.d According to elemental analysis, compound 2j was obtained as a bishydrochloride.e N-Boc 3-iodo indole (1p) was applied as a starting material.
strikingly simple methodology is highly practical and leads to a straightforward protocol for the preparation of the title compounds.Studies addressing more-sophisticated 2,5-disubstituted thiophenes for surface modification and also mesoporous hybrid materials are currently underway.

Experimental
2c: An 80 mL microwave reaction vessel, equipped with a rubber septum, was charged with 1-iodo-3-methoxybenzene (1c) (468 mg, 2.00 mmol), PdCl 2 (PPh 3 ) 2 (28 mg, 0.04 mmol, 2 mol %), CuI (16 mg, 0.08 mmol, 4 mol %), and degassed DMF (10.0 mL).The reaction mixture was flushed for 10 min with nitrogen by using a cannula.After addition of trimethylsilylacetylene (0.43 mL, 3.00 mmol) and dry triethylamine (0.55 mL, 4.00 mmol) the solution was stirred at rt for 1.5 h.Then KF (174 mg, 3.00 mmol), and methanol (5.00 mL) were subsequently added and the reaction mixture was stirred under aerobic atmosphere in the opened reaction vessel overnight at rt.After the addition of sodium sulfide nonahydrate (960 mg, 4 mmol), potassium hydroxide (224 mg, 4 mmol), and methanol (5 mL) the vessel was heated to 120 °C under microwave irradiation for 2 h.After cooling to rt the mixture was adsorbed on neutral aluminium oxide and filtered through a short plug of neutral aluminium oxide with THF as an eluent.The solvents were removed in vacuo and the residue was adsorbed on Celite ® and purified by column chromatography on silica gel (hexane) to give 215 mg (0.72 mmol, 72 %) of 2c as a lightyellow solid.R f 0.35 (n-hexane/ethyl acetate 10:1); mp 73 °C;

Figure 1 :
Figure1: Symmetrical 2,5-di(hetero)arylthiophenes 2 synthesized via the one-pot pseudo five-component Sonogashira-Glaser cyclization sequence (yields refer to 0.5 equiv of (hetero)aryl iodide).a Only one equiv of TMSA was applied in the Sonogashira step.b According to elemental analysis compound 2f was obtained with 25% hydrate.c m-Iodo nitrobenzene (1g) was applied as a starting material.d According to elemental analysis, compound 2j was obtained as a bishydrochloride.e N-Boc 3-iodo indole (1p) was applied as a starting material.

Table 1 :
Evaluation of different solvents.a bConversion in the final step (monitored by TLC).c Given yields refer to isolated and purified products.d n. i.:Not isolated.e The final step was performed in an oil bath at 90 °C for 8 h to achieve complete conversion.