Gold-catalyzed propargylic substitutions: Scope and synthetic developments

This personal account summarizes our recent developments in gold-catalyzed direct substitutions on propargylic (allylic, benzylic) alcohols, with various nucleophiles (and bi-nucleophiles) based on the σ- and/or π-acidity of gold(III) complexes. Synthetic developments are also briefly described.


Introduction
In the field of nucleophilic substitution reactions, leaving groups are mostly often obtained from alcohols but initially require their transformation to better leaving groups such as sulfonates or acetates. For economic, environmental and practical reasons it is therefore of interest to develop new experimental conditions for the direct substitution of activated alcohols such as tertiary, allylic, benzylic or propargylic ones [1][2][3][4]. Since some pioneering work using stoichiometric amounts of Lewis acid catalysts [3][4][5], much effort has been devoted to this goal. In this context, we have been particularly interested in the direct substitution of propargylic alcohols, because i) the presence of the alkyne function in the substitution product allows many further synthetic modifications, ii) the challenge of controlling the possible competition between substitutions at the propargylic and/or the allenic positions [6], and iii) compared to allylic and benzylic substitutions these reactions have been studied to a far lesser extent. Direct propargylic substitutions have traditionally and efficiently been carried out using the Nicholas [7] conditions but this implies the use of stoichiometric amounts of a cobalt complex. In 1994, Murahashi [8] described in a seminal paper the propargylic substitution of monosubstituted alkynes bearing a good leaving group on the propargylic alcohol moiety, where a mechanism through a copper-allenylidene intermediate was postulated. Subsequently, Scheme 1: Gold-catalyzed propargylic substitutions. asymmetric versions have been described [9,10]. Thus, Hidai, Nishibayashi and Uemura developed a diruthenium complex catalyst for the direct substitution of monosubstituted propargylic alcohols (R 3 = H), by a large number of heteroatomic and carbon centered nucleophiles [11][12][13][14][15]. Enantiomerically pure ruthenium catalysts for asymmetric propargylic substitutions were next developed using acetone, hydrides and electron rich aromatics as nucleophiles [16][17][18]. In 2003, oxo-rhenium catalysts were introduced by Toste [19][20][21]. Substitution products were obtained in high yields with alcohols, allylsilanes, aromatic compounds and nitrogen nucleophiles. Interestingly, these reactions were not limited to monosubstituted propargylic alcohols [19][20][21][22].
In 2005, we described the direct Au(III)-catalyzed substitution of propargylic alcohols in the presence of various nucleophiles (allylsilanes, alcohols, thiols, electron rich aromatic compounds), and showed that gold probably acts as a Lewis acid to promote the formation of a stabilized propargylic carbocation intermediate [23,24]. A related reaction was subsequently reported by Dyker [25] in 2006, using azulene and 1,3dimethoxybenzene in Friedel-Crafts type reactions with benzylic and propargylic alcohols. Shortly after, Sanz and Zhan discovered, that these reactions could also be carried out under Brønsted acid and FeCl 3 catalysis, respectively [26][27][28][29]. Later, the use of copper, indium, bismuth, scandium, ytterbium, phosphomolybdic acid and iodine catalysts were reported by several groups worldwide [30][31][32][33][34][35][36][37][38][39]. These aspects have been recently reviewed [40][41][42][43]. Among all these various Lewis acid catalysts, gold stands out since it possesses a unique hard/soft Lewis acid dichotomy allowing the activation of both alcohols and π-bonds. We therefore assumed that we could take advantage of this ambivalence in order to perform new domino processes [44,45]. Moreover, due to these ambivalent properties, the control of the chemo-and regioselectivity is challenging and raises interesting mechanistic considerations.
In this special issue dedicated to "Gold catalysis for organic synthesis", we would like to give a personal account on our work related to this topic: Scope, limitations and synthetic utilization of the gold(III)-catalyzed direct substitution of alcohols and the development of domino reactions.

Gold-catalyzed alcohol substitution Scope and limitations
In the past few years, homogeneous gold catalysis has emerged as an efficient tool to activate triple bonds for the addition of various nucleophiles to alkynes. We initially anticipated that, through coordination to π-bond [46][47][48], gold catalysts may also act as propargylic alcohol-activating agents in propargylic substitutions (Scheme 1).
To validate this hypothesis, the reactivity of 1-phenyloct-2-yn-1-ol (1a, R 1 = Ph, R 2 = H, R 3 = n-pentyl) with allyltrimethylsilane in the presence of various gold catalysts at room temperature was investigated (Scheme 2, Table 1). Gratifyingly, the reaction proved to be efficient with various Au(III) reagents (at 5% catalyst loading) ( Based on the results of these initial experiments, we set out to define the scope of these reactions by first examining variations on propargylic alcohols 1a-o. As illustrated in Scheme 2, the effect of the nature of the substituent on the acetylenic position (R 3 group, Scheme 2) was examined. The following trend was observed: Ph > alkyl > SiR 3 > H >> CO 2 Et. Indeed, the best yield (2b, 97%) was obtained with propargylic alcohol 1b bearing a phenyl group and no reaction was observed when an electron-withdrawing group such as ester was present on the propargylic alcohol 1c. It is worth noting that with terminal alkynes, the product 2d was obtained in low yield (9%). The presence of various substituted aromatic groups on the propargylic position (R 1 , R 2 groups), i.e., compounds 1f-1j (for other examples, see reference [24]) gave good product yields, whilst aryl groups with strong electron-withdrawing groups such as p-NO 2 1l and p-CF 3 1k were unreactive. When the aryl group was replaced by an alkyl chain, no reaction occurred (as illustrated with 1m) whereas when two alkyl substituents were present, as in 1n, the reactivity was restored to give 2n in 59% yield. When both an alkyl and an aromatic group were both Scheme 2: Propargylic substitution: scope of substrates. present, as in 1o, a lower yield was obtained due to rapid decomposition of the product 2o at room temperature. It should be emphasized that all the allyl substituted products 2a-2o have, in general, low stabilities and decompose within a few days at room temperature. Two general conclusions can be drawn from these experiments using allylsilanes as nucleophiles: A stabilization of a positive charge (+ or δ+) on the propargylic position by electron-donating groups on the propargylic and/or acetylenic positions favors the reaction, and no product resulting from attack at the acetylenic position could be observed.
To explore further regioselectivity issues, compound 1p, which is both an allylic and a propargylic alcohol, was submitted to the same reaction conditions. A 2:2:1 inseparable mixture of S N 2p and S N ' 2q and 2r products was obtained (Scheme 3).
The Au(III)-catalyzed reaction was next investigated for diverse series of nucleophiles. A large number of nucleophiles are very In some instances unexpected selectivities and further transformations were observed. When ethanol was used as the nucleophile, the corresponding Meyer-Schuster products [49][50][51][52][53][54], first observed by Utimoto [49], were selectively obtained as illustrated with the formation of compounds 9 and 11 (Scheme 5).
Interestingly, lowering the catalyst loading to 1 mol %, the substitution product 10 could be isolated in 60% yield (along with 35% of the Meyer-Schuster product 11). This result could be explained by considering that 11 is derived from 10 through the conjugated addition of water (residual or produced during the substitution reaction) and a lower amount of gold catalyst should slow down the Meyer-Schuster process. It also suggests that, not only the OH group but also the OEt group can act as a good leaving group in these reactions. Indeed, when isolated compound 10 was subjected to Au(III) catalyst in the presence of water, 11 was obtained as the major product along with some unidentified by-products. Two consequences from these results are i) the use of an alcohol as nucleophile gives a product that can act as a substrate for further transformations (such as a Meyer-Schuster reaction), and ii) other ether (O-Si, O-C) functions can be used in these reactions. Indeed, the use of silyl protected OH groups is possible as illustrated by our group (Scheme 6, reaction 1) and by the Kirsch group (Scheme 6, reaction 2) [24,55]. In both cases selective S N ' reactions were observed, not only with oxygen nucleophiles but also with nitrogen and electron-rich aromatic nucleophiles [55]. It is worth noting that a mixture of S N and S N ' products was obtained when allylsilane was used as the nucleophile with related substrates (Scheme 3).
When acetylacetone was used as the nucleophile, no reaction occurred with 1r at room temperature, whereas in refluxing dichloroethane the substitution product 16 led to a mixture of products via triple bond hydration to give 17 [49,50,56] and furan formation to afford 18 (Scheme 7). The furan may possibly result from intramolecular addition of the enol form of acetylacetone. Related experiments have been independently reported by Arcadi [57].
The main limitations of the methodology appeared when azido (TMSN 3 ), amides and phosphorus centered nucleophiles were used as nucleophiles: In these cases, either decomposition products or dimerization to the ether product were observed [58].
As previously noted, the lack of reactivity when aryl substituents bearing electron-withdrawing groups are present either at the propargylic or acetylenic positions, or when the propargylic position is only substituted by one alkyl group, suggests that an S N 1-type reaction is involved. To confirm this hypothesis, the reaction starting from enantiomerically pure 1b was carried out and the resulting substitution product 2b was shown to be the racemate (Scheme 8). This result showed that the presence of triple bond may be not necessary and prompted us to extend the methodology to other activated alcohols such as diarylmethanol, benzylic and allylic alcohols (Scheme 9) [24,[59][60][61]. This reaction was further extended to tertiary alcohols by Asensio [62]. Shortly after the publication of our seminal results [23], the direct substitution of activated (propargylic, benzylic and allylic) alcohols became of increasing interest and many efficient alternative methods were proposed [40][41][42][43]. Among these, great interest has been shown in the use of APTS or iron(III) catalysts due to their low cost and toxicity [26][27][28][29]. Despite its high cost, gold catalysis has some intrinsic benefits compared to other reported methodologies. Firstly, these Au(III)-catalyzed substitutions are clean and efficient processes and are usually carried out at room temperature. This point was very nicely illustrated by Dyker: In the reaction of 2,4-dimethoxybenzaldehyde with propargylic alcohol 1b (Scheme 10), no substitution occurred at room temperature with a stoichiometric amount of BF 3 ·Et 2 O but was complete with only 1 mol % of AuCl 3 as catalyst [25].
Secondly, gold(III) possesses π-acidic properties and is able to activate triple bonds towards the addition of nucleophiles. Thus different reactivities and selectivities might be expected under gold catalysis conditions. For example, it could be interesting to combine both Lewis and π-acidities to promote domino reactions [44,45].

Domino reactions in the presence of bi-nucleophiles
We anticipated that by using bi-nucleophiles HNu 1 -Nu 2 H, the first nucleophilic substitution would be followed by activation of the triple bond and addition of the remaining nucleophilic group to the alkyne (Scheme 11) [63].
Whereas no reaction occurred with bis-protected hydrazines, unexpected reactions occurred with protected (P = Cbz, PhSO 2 ) hydroxylamines (Scheme 12). In model reactions of propar-gylic alcohol 1 with PhSO 2 NHOH in the presence of NaAuCl 4 neither the propargylic substitution product 22 nor the expected isoxazoline 23 could be observed in the crude product. Instead a 1:1 mixture of unreacted alcohol 1 and compound 24 formally resulting from the addition of a second equivalent of hydroxylamine was obtained. By using 2.1 equivalents of the Cbz-or PhSO 2 -protected hydroxylamines, compounds 24a-c were isolated in 67-79% yields as single diastereomers. Determination of the structures of 24 was a challenging task and could only be determined by an X-ray crystal structure determination on compound 24b [63]. Efforts to regenerate isoxazolines 23a from 24a by acidic treatment, under various conditions, were unsuccessful in our hands. Notably, in the presence of 37% aqueous HCl in refluxing methanol, the transacetalized product 25 was isolated in 68% yield (Scheme 13).
The desired isoxazolines cannot be directly obtained from propargylic alcohols 1 in the presence of gold(III) catalysts. From these preliminary experiments, it appears that the addition of hydroxylamine to the isoxazoline double bond is much faster than propargylic substitution. Consequently, the only possibility to obtain these isoxazolines would be to realize the propargylic substitution first of all (and consume all of the hydroxylamine) and subsequently perform the cyclization. Since iron(III) was known to be inefficient in the hydration of triple bonds [64,65], we anticipated that its use would lead only to the propargylic substitution product [28,29], and then, by adding a gold(III) catalyst, the cyclization could occur to yield the isoxazolines.
Indeed, in the presence of iron(III) chloride [66][67][68][69], the substitution product 22a was obtained in 87% yield, with no trace of the cyclized product even after prolonged reaction at reflux (Scheme 14). Very recently, Darcel described the iron(III) hydration of terminal alkynes [65]. These conditions were attempted to cyclize 22a but in our hands only extensive decomposition was observed. We thus turned our attention to gold-catalyzed cyclization of 22a which proved more difficult than initially expected ( Table 2). As shown in Table 2, different metal salts were tried, and it was found that the best conditions were obtained when gold(III) was used in the presence of a catalytic amount (30 mol %) of DMAP [70].
We next tried to develop one-pot conditions for the direct transformation of propargylic alcohols 1 to isoxazolines 23. Thus, treatment of the propargylic alcohol first of all with FeCl 3 to promote the propargylic substitution followed by reaction with NaAuCl 4 , in the presence of DMAP 30 mol %, for the cyclization step as outlined in Scheme 15 proved to be efficient and compounds 23a-i were obtained in 38-86% yield (Scheme 15).
Prompted by the apparently simplicity of the addition of hydroxylamine to the isoxazoline double bond (Scheme 12), we next tried to promote the gold-catalyzed addition of various nucleophiles. As illustrated in Scheme 16, the reaction proved restricted to alcohols and no reaction occurred with TsNH 2 or electron-rich aromatic compounds such as 1,3-dimethoxybenzene.
Some contradictions arose from these experiments. On one hand, when propargylic alcohols 1 and protected hydroxylamines were treated with gold catalyst at room temperature (Scheme 12), the reactions were rapid and led to the formation of 24. On the other hand, when trying to perform gold-catalyzed cyclization of the isolated propargylic substitution product 22, the reaction appeared to be difficult and required the addition of a co-catalytic amount of DMAP, under reflux conditions, to be effective. Moreover, it has been shown that oxygen nucleophiles are prone to attack at the acetylenic site. Thus the reaction pathway could proceed in one of two ways: First, propargylic substitution by the nitrogen of the nucleophile followed by the cyclization (Scheme 17, path A) or attack on the acetylenic position by the oxygen of the nucleophile followed by intramolecular propargylic substitution (Scheme 17, path B). The determination of the reaction pathway is a challenging task and to gain more insight we designed a model substrate 30 bearing a methoxy group in a quaternary substituted propargylic position and a (nucleophilic) alcohol function in the homopropargylic position. In order to deactivate the triple bond toward nucleophilic addition, a TMS group was placed in the acetylenic position. This substrate, obtained from the addition of an allenyl(cyano)cuprate on butyraldehyde [71][72][73], was reacted with allyltrimethylsilane. The reaction was totally regioselective for the propargylic site. Different reaction paths can be expected: i) The formation of a propargylic carbocation that can be attacked by allyltrimethylsilane or vicinal hydroxy group and ii) homopropargylic alcohol attack on the triple bond. The only product that could be isolated was the furan 31 which was obtained in 78% yield, with no trace of any product arising from an allylsilane attack (Scheme 18). The formation of the furan might be explained by a direct attack of the homopropargylic alcohol on the triple bond or a gold-catalyzed rearrangement of a transient epoxide as recently described by Blanc and Pale [74][75][76].

Synthetic developments
This result prompted us to explore the synthesis of functionalized furans from various homopropargylic alcohols obtained on a multi-gram scale, by our recently described allenylcuprate chemistry [71][72][73]. In the meantime, Aponick [77] and Akai [78]  From allylated substitution products 2, we were also able to develop two synthetic applications. In an one-pot, sequential, reaction with first a gold(III)-catalyzed propargylic substitution followed by a gold(I)-catalyzed cycloisomerization, the bicyclic compound 37 was obtained in 71% yield [24,[80][81][82]. Very recently, a remarkable one-pot reaction using an original gold(III) catalyst has been described by Fairlamb [82]. We were Scheme 20: Propargylic substitutions: Synthetic applications. GH2 = Grubbs-Hoveyda 2 nd generation catalyst.
From isoxazolines 23, we were also able to promote, under micro-waves irradiation, a Baldwin rearrangement to yield the cis-acylaziridines 39, with high diastereoselectivity [85]. Finally, from propargylic alcohols 1, a sequential iron(III)catalyzed propargylic substitution [28,29] followed by a NEt 3mediated elimination of the sulfonyl group and oxime cyclization gave, in a one-pot sequence, the corresponding isoxazoles 40 in good yields (Scheme 20) [86].

Conclusion
In conclusion, we have developed gold(III)-catalyzed direct propargylic (allylic, benzylic) substitutions which have proved efficient with a great number of nucleophiles under mild conditions (dichloromethane, room temperature). A notable limitation of this methodology is since a stabilized positive charge is involved the scope of the reaction is limited to the use of tertiary or benzylic (allylic) propargylic alcohols. On the other hand, such a mechanism also implies that in the presence of chiral gold catalyst, through coordination to the triple bond (Scheme 1), enantioselective transformations could be obtained. We also found that with chiral gold(III) complexes very deceiving results can be obtained. It is worth noting that, recently, Bandini described very impressive enantioselective intramolecular direct allylic substitutions using chiral gold(I) complexes [87,88]. We also took advantage of the π-and σ-(Lewis) acidities of gold(III) complexes to promote domino reactions with bi-nucleophiles such as protected hydroxylamines. In the presence of gold(III), the expected isoxazolines 23 could not be directly obtained but required a dual iron(III)/ gold(III) catalysis to be effective. Nevertheless, gold catalysts exert interesting π-and σ-Lewis properties, allowing direct nucleophilic substitution of various di or tri-substituted alcohols and cyclization reactions under mild conditions. This methodology gives easy access to various elaborated molecules with varied functionalities, as illustrated in this account.