Imidazolinium and amidinium salts as Lewis acid organocatalysts

The application of imidazolinium and amidinium salts as soft Lewis acid organocatalysts is described. These salts were suitable catalysts for the activation of unsaturated thioesters in a Diels–Alder reaction and in the ring opening of thiiranes and epoxides. The products were isolated in good yields. The mild catalysts did not cause desulfurization of the products containing a thiol or thiocarbonyl group.


Introduction
Salts with melting points below 100 °C are known as ionic liquids and are often used as novel solvents for reactions and electrochemical processes [1]. Several of these solvents can contribute to the research field of "green chemistry" [2]. The most common used ionic liquids are based on imidazolium cations. Next to their application in catalytic reactions [3][4][5][6], they are also capable of catalyzing reactions themselves, either in substoichiometric amounts or as reaction medium due to hydrogen-bond activation of the protons of the imidazolium cation [7][8][9][10] and other variables, such as π-orbital and charge-charge interactions [8][9][10].
Taking the soft Lewis acidic character of imidazolinium salts into consideration, we were interested to apply these salts in a Diels-Alder reaction with ethyl crotonthioate as dienophile. Due to the low electronegativity of sulfur it would be difficult to catalyze this reaction with hydrogen-bond activation catalysts [18]. The utilization of the soft Lewis basic sulfur groups in this reaction is rare. Often mercury Lewis acids are applied [19][20][21][22] to activate the sulfur group and there is also the risk of desulfurization [23].

Scheme 2: Diels-Alder reaction catalysed with imidazolinium salts.
First a few metal-based Lewis acids were applied in the reaction. BF 3 •Et 2 O is known to activate also sulfur carbonyl groups [24] and gave the product in 90% yield, while TMSOTf gave the product in 55% yield. In both cases the endo product was the major product. The reaction was followed by TLC and the temperature was gradually increased from -10 to 45 °C over 4 days in ca. 10 °C steps.
Next, imidazolinium salt 7 [25] was used in the reaction. The formation of the product was observed at 45 °C; however, the product was isolated only in a low yield of 8%. In toluene no reaction was observed even under reflux. In dioxane under reflux a low yield of 6% was obtained with a low endo/exo ratio of (3:1). Salt 8 [25] and 9 [25] gave similar poor results as salt 7 [25]. Finally, the bis-imidazolinium salt 10 [12] gave the product in 69% yield with an endo/exo ratio comparable to BF 3 •Et 2 O. The reaction started slowly at 10 °C. In addition, the similar salt 11 [12] gave the product in a comparable yield of 66%. Although in all cases the product was racemic, the results show that bis-imidazolinium salts can be applied as Lewis acid organocatalysts to activate a thiocarbonyl group.
Next, the behavior of these salts in the ring opening of a thiirane was explored. No activity was observed with salt 9 in the ring opening with aniline. Therefore, the more active bis-imidazolinium salt 10 was applied with thiirane 12 and aniline in CH 2 Cl 2 . A yield of 18% was obtained. However, in the absence of a solvent the yield increased to 98% after 16 h (Scheme 3). In the absence of a catalyst a yield of 12% was obtained under neat conditions. Product 13 was obtained in all reactions as racemate in the error range of the HPLC measurements. Next, several salts were explored in the ring opening of cyclohexene epoxide with aniline (Scheme 4, Table 2). A reaction in CH 2 Cl 2 in the absence of the catalyst gave a yield of 10% after 24 h ( Table 2, entry 1).
The camphor based salt 16 gave a yield of 24%, while bisimidazolinium salt 17 resulted in a yield of 60% (Table 2, entries 2 and 3). The bis-imidazolinium salts 10 and 11 gave lower yields compared to 17. However, when the reaction was carried out in the absence of a solvent, the yield increased with salts 10 and 11 to 98 and 96%, respectively ( Table 2, entries 6  and 7).
Compared to sulfur, oxygen is a good hydrogen-bond acceptor. Hence, also imidazolinium salts with a C(2)H unit were applied in the reaction. Here, an activation of the epoxide can be also possible through hydrogen bonding next to the direct interaction with the positively charged NCN center. While salt 18 displayed very low catalytic activity, salt 19 gave the product in 78% yield (  explained by the better delocalization of the positive charge in the planar sp 2 -centered imidazoline scaffold in salt 18. Meanwhile the special geometry of 7-membered 1,3-diazepinium cations such as 19 does not allow the planar conformation to be kept, thus the positive charge is less delocalized over the NCN atoms (Scheme 4) [26][27][28][29]. Salt 16, incorporating a sixmembered ring as the smallest ring, displayed a catalytic activity between salt 18 and 19. Salt 20, with a larger steric environment around the amidinium unit next to the nitrogen atoms, gave a yield of only 38% ( Table 2, entry 11). On the other hand salt 21 gave the product in 99% yield after 6 h (Table 2, entry 12). By changing the solvent from dichloromethane to toluene the reaction time was even further reduced with salt 21, and the product was isolated in 89% yield ( Table 2, entry  14). In all cases product 15 was racemic in the error range of the HPLC measurements.
Salt 17 was prepared according to Scheme 5. The synthetic route involved a tetraamine formation via amidation under neat conditions and reduction with LAH, furnishing the product in 98% yield over two steps. Next, the aminal formation under neat conditions was performed. The aminal was further oxidized to a bromide salt by N-bromoacetamide in dimethoxyethane. The bromide counter anion was further efficiently replaced by a tetrakis(3,5-bis(trifluoromethyl)phenyl)borate anion providing the salt 17 by anion metathesis.
The 7-membered 1,3-diazepinium salts were prepared according to Scheme 6. Salts 19 and 20 were prepared in a standard way by treatment with triethyl orthoformate in the presence of ammonium tetrafluoroborate followed by anion metathesis in 33 and 29% yield, respectively.
Due to the low yield, salt 21 was prepared through a different route. First amine 27 [30] was transformed with formaldehyde to the aminal 28. The latter could be oxidized to the corresponding bromide salt, which was transformed directly by anion metathesis to the salt 21.

Conclusion
It was possible to prepare new metal-free Lewis acids containing bis-imidazolinium cations and investigate the salts as organocatalysts. Although with enantiopure chiral salts no enantiomeric excess was observed, it was shown for the first time that these salts can interact with thiocarbonyl groups and thiiranes in order to activate these substrates. In addition, it was found that 7-membered 1,3-diazepinium cations are good catalysts for the ring opening of epoxides and that these salts are more reactive than imidazolinium salts.

Supporting Information
Supporting Information File 1 Experimental part.