Consecutive cross-coupling reactions of 2,2-difluoro-1-iodoethenyl tosylate with boronic acids: efficient synthesis of 1,1-diaryl-2,2-difluoroethenes

Summary The cross-coupling reactions of 2,2-difluoro-1-iodoethenyl tosylate (2) with 2 equiv of boronic acids in the presence of catalytic amounts of Pd(OAc)2 and Na2CO3 afforded the mono-coupled products 3 and 5 in high yields. The use of 4 equiv of boronic acids in the presence of catalytic amount of Pd(PPh3)2Cl2 and Na2CO3 in this reaction resulted in the formation of symmetrical di-coupled products 4 in high yields. Unsymmetrical di-coupled products 4 were obtained in high yields from the reactions of 3 with 2 equiv of boronic acids in the presence of catalytic amounts of Pd(OAc)2 and Na2CO3.


Results and Discussion
Although the chemistry of the 2,2-difluoroethenylidene species as a building block has been well established in recent years, 2,2-difluoro-1-iodoethenyl tosylate (2) was not previously prepared. However, we easily synthesized the starting material 2 from the reaction of 2,2,2-trifluoroethyl tosylate (1) with 2 equiv of LDA in THF at −78 °C, followed by treatment with 1 equiv of iodine (Scheme 1).
First, we attempted the consecutive palladium-catalyzed crosscoupling reaction of 2 with different arylboronic acids to afford unsymmetrical 1,1-diaryl-2,2-difluoroethenes. Since the use of a proper base in the Suzuki-Miyaura reaction is an important factor to increase the yield of coupled product, we screened bases to get the optimized reaction conditions. When 2 was reacted with 1 equiv of phenylboronic acid in the presence of 5 mol % of Pd(OAc) 2 and Cs 2 CO 3 (2 equiv) in methanol at room temperature for 15 h, mono-and di-coupled products 3a and 4a were obtained in 21% and 10% yields, respectively, along with a small amount of the self-coupled product (less than 5%) and reduced product. The use of 2 equiv of phenylboronic acid in the same reaction increased the yield of 3a (38%) and 4a (19%). However, the use of high molecular amounts of Pd catalyst did not improve the yield of 3. The same reaction was performed with K 2 CO 3 instead of Cs 2 CO 3 as a base to give 3a and 4a in 56% and 16% yields. The use of K 3 PO 4 in this reaction provided similar results. Finally, the optimized reaction condition was achieved by using Na 2 CO 3 as a base, in which only mono-coupled product 3a was obtained in 92% yield along with the self-coupled product derived from the excess boronic acid. When the reaction was performed in the presence of 5% Pd(PPh 3 ) 2 Cl 2 or Pd(CH 3 CN) 2 Cl 2 instead of Pd(OAc) 2 , di-coupled product 4a was always formed in 6-13% yield. Optimization of the cross-coupling reaction of 2 with phenylboronic acid is summarized in Table 1. After the successful coupling reaction of 2 with phenylboronic acid under the optimized reaction conditions, the same reaction was performed with other arylboronic acids bearing a proton, fluoro, chloro, methyl, methoxy and trifluoromethyl on the ortho-, metaor para-position of the benzene ring. Reactions were successful with both electron-donating and electron-withdrawing arylboronic acids to produce the corresponding 2,2difluoro-1-arylethenyl tosylates 3 in excellent isolated yields. Especially, the coupling reactions with arylboronic acids having an electron-donating group at the ortho-position of the benzene ring also provided the corresponding coupled products 3l-n in good yields. The cross-coupling reactions of 2 with arylboronic acids are summarized in Table 2.
Direct diarylation reactions of 2 with arylboronic acids were also performed because di-coupled product 4a was formed in a mono-arylation reaction (Table 1) and also a recent work showed a successful cross-coupling reaction of nonfluorinated enol tosylates with a variety of arylboronic acids [23]. We attempted a direct diarylation reaction of 2 with phenylboronic acid to establish the optimized reaction conditions. Initial reaction of 2 with 3 equiv of phenylboronic acid in the presence of 5 mol % of Pd(OAc) 2 and 2 equiv of Na 2 CO 3 in MeOH at room temperature for 22 h afforded the di-coupled product 4a in 30% yield. The yield of 4a was increased to 39% using 4 equiv of phenylboronic acid in this reaction. When the reaction was performed with K 2 CO 3 or K 3 PO 4 as a base under the same reaction conditions, the desired product 4a was obtained in up to 49-52% yield. The use of more soluble Cs 2 CO 3 resulted in the formation of 4a in 61% yield. Increasing the reaction temperature did not improve the of yield of 4a. We also examined the effect of the palladium catalyst in this reaction. Therefore, the same reaction was performed in the presence of 5 mol % of Pd(PPh 3 ) 2 Cl 2 instead of Pd(OAc) 2 , in which 4a was obtained in 75% yield. Other palladium catalysts such as Pd(CH 3 CN) 2 Cl 2 did not cause to improve the yield of 4a. Optimization of the di-coupling reaction of 2 with phenylboronic acid is summarized in Table 3.
Diarylation reactions of 2 with arylboronic acids substituted by fluoro, chloro, methyl, methoxy, nitro and trifluoromethyl substituent at the metaor para-position of the benzene ring proceeded well under the optimized reaction conditions to give the corresponding symmetrical di-coupled products 4b-k in 51-86% yield. However, coupling reactions with arylboronic acids having a substituent such as chloro, methyl or a methoxy group at the ortho-position of the benzene ring to produce the di-coupled products 4l-n were unsuccessful. This result probably indicates that the coupling process could be affected by steric hindrance in the second coupling reaction step. The di-coupling reactions of 2 with arylboronic acids are summarized in Table 4.
a Isolated yield. b A trace amount of product was obtained.
Unsymmetrical 1,1-diaryl-2,2-difluoroethenes can be prepared from the coupling reaction of mono-coupled tosylates 3 with arylboronic acids under similar reaction conditions. Therefore, the cross-coupling reaction of 3a with 2 equiv of p-chloro-phenylboronic acid in the presence of 5 mol % Pd(PPh 3 ) 2 Cl 2 and 2 equiv of Cs 2 CO 3 in MeOH at room temperature for 12 h afforded 1,1-diaryl-2,2-difluoroethene 4o in 89% yield. The similar reactions of 3a with arylboronic acids having a a Isolated yield. substituent such as fluoro, methyl, methoxy, and trifluoromethyl at the metaor para-position of the benzene ring also provided the corresponding 1,1-diaryl-2,2-difluoroethenes 4p-v in 75-90% yields. The coupling reaction between 3c and m-methylphenylboronic acid also resulted in the formation of 4w in 79% yield. Similarly, 3k having an electron-withdrawing group on the benzene ring was also reacted with p-methylphenylboronic acid to yield 4x in 70% yield. Table 5 summarizes the results of the coupling reactions of 3 with several arylboronic acids to give unsymmetrical 1,1-diaryl-2,2-difluoroethenes.
The successful cross-coupling reaction of 2 with arylboronic acids prompted us to examine similar coupling reactions with alkenylboronic acids. The same reaction conditions of the mono-coupling reaction of 2 with arylboronic acid was applied to the alkenylation of 2. Therefore, the cross-coupling reaction of 2 with trans-2-phenylethenylboronic acid in the presence of 5 mol % of Pd(OAc) 2 and 2 equiv of Na 2 CO 3 in MeOH at room temperature for 15 h provided the cross-coupled product 5a in 85% yield. The similar reaction of 2 with trans-oct-1-enylboronic acid afforded the cross-coupled product 5b in 81% yield. The cross-coupling reactions of 2 with alkenylboronic acids are summarized in Table 6.

Conclusion
In summary, we have successfully developed the consecutive cross-coupling reactions of 2,2-difluoro-1-iodoethenyl tosylate (2) with arylboronic or alkenylboronic acids in the presence of a suitable Pd catalyst and a base to afford 2,2-diaryl-1,1-difluoroethenes. The developed method provides synthetically useful advantages such as a straightforward procedure to give symmetrical and unsymmetrical 2,2-diaryl-1,1-difluoroethenes and the use of a less toxic reagent such as boronic acid.

Supporting Information
Supporting Information File 1 Experimental details, full spectroscopic data and spectra.