TY - JOUR A1 - Narra, Naganna A1 - Kaki, Shiva Shanker A1 - Prasad, Rachapudi Badari Narayana A1 - Misra, Sunil A1 - Dhevendar, Koude A1 - Kontham, Venkateshwarlu A1 - Korlipara, Padmaja V. T1 - Synthesis and evaluation of anti-oxidant and cytotoxic activities of novel 10-undecenoic acid methyl ester based lipoconjugates of phenolic acids JF - Beilstein Journal of Organic Chemistry PY - 2017/// VL - 13 SP - 26 EP - 32 SN - 1860-5397 DO - 10.3762/bjoc.13.4 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.13.4 KW - anticancer KW - anti-oxidants KW - caffeic acid KW - coumaric acid KW - ferulic acid KW - phenolic lipids KW - sinapic acid KW - undecenoic acid N2 - The synthesis of five novel methyl 10-undecenoate-based lipoconjugates of phenolic acids from undecenoic acid was carried out. Undecenoic acid was methylated to methyl 10-undecenoate which was subjected to a thiol–ene reaction with cysteamine hydrochloride. Further amidation of the amine was carried out with different phenolic acids such as caffeic, ferulic, sinapic, coumaric and cinnamic acid. All synthesized compounds were fully characterized and their structures were confirmed by spectral data. The anti-oxidant activity of the synthesized lipoconjugates of phenolic acids was studied by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and also by the inhibition of linoleic acid oxidation in micellar medium by differential scanning calorimetry (DSC). The prepared compounds were also screened for their cytotoxic activity against five cell lines. It was observed that the lipoconjugates of caffeic acid, sinapic acid, ferulic acid, and coumaric acid displayed anticancer and anti-oxidant properties. The anticancer properties of these derivatives have been assessed by their IC50 inhibitory values in the proliferation of MDA-MB231, SKOV3, MCF7, DU 145 and HepG2 cancer cell lines. ER - TY - JOUR AU - Figueroa-Espinoza, M.-C. 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