Strategies for the synthesis of brevipolides

• Yudhi D. Kurniawan and
• A'liyatur Rosyidah

Beilstein J. Org. Chem. 2021, 17, 2399–2416, doi:10.3762/bjoc.17.157

• human cancer cell lines and inhibition of the chemokine receptor CCR5, make them attractive synthetic targets. This review article highlights the recent synthetic methodologies and briefly summarizes their biological activities. Keywords: brevipolides; 5,6-dihydro-α-pyrone; Furukawa-modified Simmons

• to determine bioactive chemicals in Hyptis brevipes Poit. and isolated six new 5,6-dihydro-α-pyrone derivatives 1–6 along with other known compounds, including a 5,6-dihydro-α-pyrone derivative 7 [11], from the whole plant collected in Tawangmangu village, Indonesia (Figure 1) [4]. These six new

• the chemokine receptor 5 (CCR5), isolated from the Peruvian plant Lippia alva in 2004 [11]. Further, in 2017 Pereda-Miranda and co-workers isolated five more new 5,6-dihydro-α-pyrone derivatives, namely brevipolides K–O (11–15), from the same plant [1]. The structures have been determined by a