Beilstein J. Org. Chem.2018,14, 2665–2679, doi:10.3762/bjoc.14.244
differentially protected Fmoc-Lys-(Tfa)-OH plays a vital role in attaching fluorescent tags while growing the peptide chain in an uninterrupted manner. The methodology is versatile for solid-phase resins that are sensitive to mild and strong acidic conditions when acid-sensitive side chain amino protecting
tag; Fmoc-Lys-(Tfa)-OH; prostate cancer and ovarian cancer; solid-phase peptide synthesis; Introduction
The understanding of cell processes is indispensable to devise new strategies for diagnosis and treatment of cancer and inflammatory diseases through targeted drug delivery techniques [1]. The
position of the fluorescent tag and chelating core would lie outside the surface of the protein tunnel. Moreover, differentially protected α- and ε-amino groups of the amino acid lysine (Lys), Fmoc-Lys-(Tfa)-OH, is also introduced in the peptide chain. The main purpose of this exercise is to connect the
PDF
Graphical Abstract
Figure 1:
(a) Structure of universal nova tag resin, (b) structure of H-L-Cys(Trt)-2-ClTrt resin.