Search results

Search for "azide–alkyne" in Full Text gives 123 result(s) in Beilstein Journal of Organic Chemistry.

Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells

  • Fumihiro Ishikawa,
  • Sho Konno,
  • Hideaki Kakeya and
  • Genzoh Tanabe

Beilstein J. Org. Chem. 2024, 20, 445–451, doi:10.3762/bjoc.20.39

Graphical Abstract
  • benzophenone moiety in probe 3. The samples were then reacted with TAMRA-N3 (structure shown in Figure S4, Supporting Information File 1) under copper(I)-catalyzed azidealkyne cycloaddition conditions [21] and subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis coupled with in-gel
  • are treated with a TAMRA-N3 under copper(I)-catalyzed azidealkyne cycloaddition conditions, followed by SDS-PAGE coupled with in-gel fluorescence scanning. AMS, 5′-O-sulfamoyladenosine. Competitive labeling experiments of GrsA using probe 3 in the presence of ʟ-Phe-AMS inhibitors. (A) Labeling of
PDF
Album
Supp Info
Full Research Paper
Published 26 Feb 2024
Graphical Abstract
  • wormlike nanoparticles. In rotaxanes, the utilization of metal–ligand bonding involving CuI is a common strategy for immobilizing a thread moiety within a macrocycle. However, the efficacy of such a bonding is compromised when catalysts are used in stoppering reactions, e.g., the copper-catalyzed azide
  • alkyne cycloaddition reaction. Consequently, a [2 + 2] CA–RE reaction that can yield push–pull chromophores without the use of a catalyst is exceedingly valuable as a stoppering method, even for systems featuring metal–ligand bonding. Accordingly, Diederich et al. demonstrated the synthesis of a CuI bis
PDF
Album
Review
Published 22 Jan 2024

Morpholine-mediated defluorinative cycloaddition of gem-difluoroalkenes and organic azides

  • Tzu-Yu Huang,
  • Mario Djugovski,
  • Sweta Adhikari,
  • Destinee L. Manning and
  • Sudeshna Roy

Beilstein J. Org. Chem. 2023, 19, 1545–1554, doi:10.3762/bjoc.19.111

Graphical Abstract
  • -promoted [22] azidealkyne cycloaddition reactions [17][23][24]; however, most of these strategies use high temperatures [21][25]. Herein, we report the discovery of a novel, one-step regioselective method under mild conditions to obtain 1,4,5-trisubstituted-1,2,3-triazoles from gem-difluoroalkenes
  • generated via an azidealkyne cycloaddition or a multicomponent reaction between carbonyls and azides [17]. α-Trifluoromethyl (α-CF3) carbonyls were recently utilized to generate NH-1,2,3-triazoles and fully substituted 1,2,3-triazoles [28][29]. However, there are no reports of a formal [3 + 2
  • –elimination of morpholine to gem-difluoroalkene 1 affording INT-1, which can generate product 3 via two routes (Figure 5). Route A entails the formation of an aminoalkyne intermediate, INT-2, which can participate in a [3 + 2] azidealkyne cycloaddition to form the final product 3. Alternatively, vinylic
PDF
Album
Supp Info
Letter
Published 05 Oct 2023

Application of N-heterocyclic carbene–Cu(I) complexes as catalysts in organic synthesis: a review

  • Nosheen Beig,
  • Varsha Goyal and
  • Raj K. Bansal

Beilstein J. Org. Chem. 2023, 19, 1408–1442, doi:10.3762/bjoc.19.102

Graphical Abstract
  • -donors on the catalytic activity of NHC–Cu(I) complexes for azidealkyne [3 + 2] cycloaddition reactions [67]. They determined binding constants of four NHC–CuCl complexes with two N-donors, which revealed that addition of phenanthroline to the NHC–CuCl enhanced the catalytic activity manifold. In fact
  • and co-workers [68] developed a new series of heteroleptic bis(NHC)–Cu(I) complexes and a mixed NHC–Cu–phosphine complex and employed these complexes as catalysts for azidealkyne [3 + 2] cycloaddition (Scheme 50). These cationic heteroleptic bis(NHC)–Cu complexes 131 are highly active for this
  • [Cu2(μBr)2(t-BuImCH2pyCH2L)]2 species 138 acting similar to the NHCs. A very low loading of these complexes was sufficient to catalyze the azidealkyne cycloaddition. A theoretical investigation at the DFT level confirmed the participation of the dinuclear species [(CuBr)2(μ-t-BuImCH2pyCH2NEt2)] 139
PDF
Album
Review
Published 20 Sep 2023

CuAAC-inspired synthesis of 1,2,3-triazole-bridged porphyrin conjugates: an overview

  • Dileep Kumar Singh

Beilstein J. Org. Chem. 2023, 19, 349–379, doi:10.3762/bjoc.19.29

Graphical Abstract
  • of the synthesis and properties of various porphyrin-triazole hybrids, this review will discuss some of the key reactions involved in the preparation of triazole-linked porphyrin conjugates. Keywords: azidealkyne; click chemistry; CuAAC; 1,3-dipolar cycloaddition; porphyrin; 1,2,3-triazole
  • porphyrin 126 was accomplished in four steps as shown in Scheme 24. First, porphyrin 123 was obtained by zinc metalation of the free-base porphyrin 122 using zinc acetate in a chloroform-methanol mixture. Further, the azidealkyne click reaction between porphyrin 123 and 6-azido-6-deoxy-PM-β-CD 124 in the
PDF
Album
Review
Published 22 Mar 2023

Continuous flow synthesis of 6-monoamino-6-monodeoxy-β-cyclodextrin

  • János Máté Orosz,
  • Dóra Ujj,
  • Petr Kasal,
  • Gábor Benkovics and
  • Erika Bálint

Beilstein J. Org. Chem. 2023, 19, 294–302, doi:10.3762/bjoc.19.25

Graphical Abstract
  • the other hand, sodium azide in N,N-dimethylformamide (DMF) reacts with mono-6-O-tosyl-CDs to give CD monoazides in high yields. The obtained mono(6-azido-6-deoxy)-CDs (N3-CDs) are valuable precursors that can be used as starting materials in azidealkyne click reactions; furthermore, they can be
PDF
Album
Supp Info
Full Research Paper
Published 09 Mar 2023

Inline purification in continuous flow synthesis – opportunities and challenges

  • Jorge García-Lacuna and
  • Marcus Baumann

Beilstein J. Org. Chem. 2022, 18, 1720–1740, doi:10.3762/bjoc.18.182

Graphical Abstract
  • -butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine on polystyrene) which is valuable for reaction scale-ups [75] is used. Alternatively, a CuAAc (copper-catalyzed azidealkyne cycloaddition) reaction has been demonstrated where the copper catalyst is supported on an Amberlist A-21 resin
PDF
Album
Perspective
Published 16 Dec 2022

A novel bis-triazole scaffold accessed via two tandem [3 + 2] cycloaddition events including an uncatalyzed, room temperature azide–alkyne click reaction

  • Ksenia Malkova,
  • Andrey Bubyrev,
  • Vasilisa Krivovicheva,
  • Dmitry Dar’in,
  • Alexander Bunev and
  • Mikhail Krasavin

Beilstein J. Org. Chem. 2022, 18, 1636–1641, doi:10.3762/bjoc.18.175

Graphical Abstract
  • proceeded further, in uncatalyzed fashion at room temperature and yielded, after intramolecular azidealkyne click reaction novel, structurally intriguing bistriazoles. Keywords: α-acetyl-α-diazomethane sulfonamide; intramolecular click reaction; uncatalyzed; room temperature; 1,2,3-triazoles
  • molecular scaffold. Pondering various opportunities for post-condensational modifications of the 1,5-disubstituted 1,2,3-triazole core according to this strategy, we turned our attention to such powerful transformation as the azidealkyne [3 + 2] cycloaddition (also known as the azidealkyne click reaction
  • ) [6]. Indeed, if an alkyne and an azido group were strategically positioned within the structure of the amine and the aldehyde components for the reaction with 1, subsequent intramolecular azidealkyne cycloaddition would be a feasible event which would create a polycyclic bis-1,2,3-triazole framework
PDF
Album
Supp Info
Letter
Published 02 Dec 2022

Scope of tetrazolo[1,5-a]quinoxalines in CuAAC reactions for the synthesis of triazoloquinoxalines, imidazoloquinoxalines, and rhenium complexes thereof

  • Laura Holzhauer,
  • Chloé Liagre,
  • Olaf Fuhr,
  • Nicole Jung and
  • Stefan Bräse

Beilstein J. Org. Chem. 2022, 18, 1088–1099, doi:10.3762/bjoc.18.111

Graphical Abstract
  • nitrogen-enriched quinoxaline-based structures. Literature-known procedures for such a quinoxaline modification starting from tetrazolo[1,5-a]quinoxalines 1 are the synthesis of 1,2,3-triazoloquinoxalines 3 via copper-catalyzed azidealkyne cycloaddition (CuAAC) [10] and the synthesis of imidazo[1,2-a
  • 1,2,3-triazoloquinoxalines 3 and imidazo[1,2-a]quinoxalines 2 under conditions known for copper-catalyzed azidealkyne cycloaddition (CuAAC) [10]. The currently published porphyrin-catalyzed process requires glovebox conditions and the use of an expensive catalyst [11]. We intend to elucidate the
  • reactions and denitrogenative annulation according to Roy et al. [11]. Copper-catalyzed azidealkyne cycloadditions are initiated via the (dual) complexation of the alkyne, whereas denitrogenative annulation on 1,2,3,4-tetrazoles is assumed to start via complexation of the open-form azide 18 (see Scheme 4
PDF
Album
Supp Info
Full Research Paper
Published 24 Aug 2022

Synthesis of novel alkynyl imidazopyridinyl selenides: copper-catalyzed tandem selenation of selenium with 2-arylimidazo[1,2-a]pyridines and terminal alkynes

  • Mio Matsumura,
  • Kaho Tsukada,
  • Kiwa Sugimoto,
  • Yuki Murata and
  • Shuji Yasuike

Beilstein J. Org. Chem. 2022, 18, 863–871, doi:10.3762/bjoc.18.87

Graphical Abstract
  • reagents and 1,3-dipolar azidealkyne cycloaddition based on the alkyne moiety. Keywords: alkynyl imidazopyridinyl selenide; copper catalyst; imidazo[1,2-a]pyridine; selenium; tandem reaction; terminal alkyne; Introduction Imidazo[1,2-a]pyridines are important heterocycles that serve as key functional
  • –Prakash reagent (TMSCF3) in the presence of Cs2CO3 as base in MeCN at 0 °C gave product 7 with a trifluoromethyl group. Stefani et al. reported the 1,3-dipolar azidealkyne cycloaddition (AAC) of organotellanyl alkynes with organic azides in the presence of a copper reagent to form 5-organotellanyl-1,2,3
  • regioselective 1,3-dipolar azidealkyne cycloaddition to form 5-selanyl-1,2,3-triazole. The investigation of the biological activity of the compounds obtained in this study and the application of this synthesis route using other heterocycles, instead of imidazopyridine, are currently underway in our laboratory
PDF
Album
Supp Info
Full Research Paper
Published 19 Jul 2022

Anomeric 1,2,3-triazole-linked sialic acid derivatives show selective inhibition towards a bacterial neuraminidase over a trypanosome trans-sialidase

  • Peterson de Andrade,
  • Sanaz Ahmadipour and
  • Robert A. Field

Beilstein J. Org. Chem. 2022, 18, 208–216, doi:10.3762/bjoc.18.24

Graphical Abstract
  • sialic acid derivatives in good yields and high purity via copper-catalysed azidealkyne cycloaddition (CuAAC, click chemistry) and evaluated their activity towards TcTS and neuraminidase. Surprisingly, the compounds showed practically no TcTS inhibition, whereas ca. 70% inhibition was observed for
  • ) has also been introduced at C-2 of α-triazole-linked sialic acid derivatives modified at C-9 as ligands for the transmembrane glycoprotein CD22 [21]. In this sense, we have synthesised a small series of 1,2,3-triazole-linked sialic acid derivatives via copper-catalysed azidealkyne cycloaddition
  • 3a–h via copper-catalysed azidealkyne cycloaddition (CuAAC) from the key intermediate 1 (B). TcTS and neuraminidase hydrolase activity (A) as well as TcTS transferase activity (B) in the presence of an acceptor substrate. TcTS and neuraminidase inhibition by 1,2,3-triazole-linked sialic acid
PDF
Album
Supp Info
Full Research Paper
Published 17 Feb 2022

Exfoliated black phosphorous-mediated CuAAC chemistry for organic and macromolecular synthesis under white LED and near-IR irradiation

  • Azra Kocaarslan,
  • Zafer Eroglu,
  • Önder Metin and
  • Yusuf Yagci

Beilstein J. Org. Chem. 2021, 17, 2477–2487, doi:10.3762/bjoc.17.164

Graphical Abstract
  • , Turkey King Abdulaziz University, Faculty of Science, Chemistry Department, 21589 Jeddah, Saudi Arabia 10.3762/bjoc.17.164 Abstract The development of long-wavelength photoinduced copper-catalyzed azidealkyne click (CuAAC) reaction routes is attractive for organic and polymer chemistry. In this study
PDF
Album
Supp Info
Full Research Paper
Published 23 Sep 2021

Sustainable manganese catalysis for late-stage C–H functionalization of bioactive structural motifs

  • Jongwoo Son

Beilstein J. Org. Chem. 2021, 17, 1733–1751, doi:10.3762/bjoc.17.122

Graphical Abstract
  • conjugative transformations, such as azidealkyne [3 + 2]-cycloaddition [30][31][32][33][34][35][36][37]. Based on their previous late-stage fluorination studies [22][25], Groves et al. further showcased a manganese(III)–salen-catalyzed azidation process using an aqueous azide solution as a convenient azide
PDF
Album
Review
Published 26 Jul 2021

A recent overview on the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles

  • Pezhman Shiri,
  • Ali Mohammad Amani and
  • Thomas Mayer-Gall

Beilstein J. Org. Chem. 2021, 17, 1600–1628, doi:10.3762/bjoc.17.114

Graphical Abstract
  • -catalyzed azidealkyne cycloaddition (CuAAC) for the synthesis of 1,4-disubstituted 1,2,3-triazole derivatives was initially discovered by the groups of Meldal and Sharpless. Then, Ru-catalyzed azidealkyne cycloaddition (RuAAC), affording selectively 1,5-disubstituted 1,2,3-triazoles, was introduced [38
  • decrease in the yield [47]. Some research groups have utilized strain-promoted azidealkyne cycloaddition reactions (SPAAC) on side chains to afford polymer-based prodrugs. Generally, a range of key strained cyclooctyne derivatives 52 could be reacted with aliphatic azides 51 via this strategy to give
  • species for the subsequent catalytic run (Scheme 41) [63]. Kumar et al. presented a novel protocol for the synthesis of highly functionalized 1,2,3-triazole-fused 5-, 6-, and 7-membered rings 152–154 via azidealkyne cycloaddition, followed by C(sp2)−H functionalization of the 1,2,3‐triazole intermediate
PDF
Album
Review
Published 13 Jul 2021

Double-headed nucleosides: Synthesis and applications

  • Vineet Verma,
  • Jyotirmoy Maity,
  • Vipin K. Maikhuri,
  • Ritika Sharma,
  • Himal K. Ganguly and
  • Ashok K. Prasad

Beilstein J. Org. Chem. 2021, 17, 1392–1439, doi:10.3762/bjoc.17.98

Graphical Abstract
  • nucleosides were further reacted with propargylated nucleobases through a copper-catalyzed azidealkyne cycloaddition (CuAAC) reaction followed by treatment with methanolic ammonia to give the C-3′-substituted double-headed ribofuranonucleosides 46a–c and 50a–e (Scheme 11) [36]. The double-headed nucleosides
PDF
Album
Review
Published 08 Jun 2021

Synthesis of β-triazolylenones via metal-free desulfonylative alkylation of N-tosyl-1,2,3-triazoles

  • Soumyaranjan Pati,
  • Renata G. Almeida,
  • Eufrânio N. da Silva Júnior and
  • Irishi N. N. Namboothiri

Beilstein J. Org. Chem. 2021, 17, 762–770, doi:10.3762/bjoc.17.66

Graphical Abstract
  • Meldal have independently developed a copper-catalysed azidealkyne cycloaddition that accelerated the rate of the reaction and allowed the selective preparation of 1,5-disubstituted 1,2,3-triazoles [16][17][18][19]. As noted above, a wide range of methods are available in the literature for the
PDF
Album
Supp Info
Letter
Published 31 Mar 2021

Effective microwave-assisted approach to 1,2,3-triazolobenzodiazepinones via tandem Ugi reaction/catalyst-free intramolecular azide–alkyne cycloaddition

  • Maryna O. Mazur,
  • Oleksii S. Zhelavskyi,
  • Eugene M. Zviagin,
  • Svitlana V. Shishkina,
  • Vladimir I. Musatov,
  • Maksim A. Kolosov,
  • Elena H. Shvets,
  • Anna Yu. Andryushchenko and
  • Valentyn A. Chebanov

Beilstein J. Org. Chem. 2021, 17, 678–687, doi:10.3762/bjoc.17.57

Graphical Abstract
  • followed by microwave-assisted intramolecular azidealkyne cycloaddition (IAAC) gave a series of target heterocyclic compounds in moderate to excellent yields. Surprisingly, the normally required ruthenium-based catalysts were found to not affect the IAAC, only making isolation of the target compounds
  • to a large number of diverse heterocyclic compounds [10][11]. Over the past decade, several cases of using an Ugi four-component reaction (Ugi-4CR) in combination with intramolecular azidealkyne cycloaddition (IAAC) for the synthesis of 1,2,3-triazolobenzodiazepines were reported [3][7][12][13][14
  • availability of previously described methods for the synthesis of 1,2,3-triazolobenzodiazepines represented in Scheme 1, they have such drawbacks as long reaction time, use of toxic solvents, additional catalysts, etc. In this article, we present a novel tandem Ugi/catalyst-free intramolecular azidealkyne
PDF
Album
Supp Info
Full Research Paper
Published 08 Mar 2021

1,2,3-Triazoles as leaving groups: SNAr reactions of 2,6-bistriazolylpurines with O- and C-nucleophiles

  • Dace Cīrule,
  • Irina Novosjolova,
  • Ērika Bizdēna and
  • Māris Turks

Beilstein J. Org. Chem. 2021, 17, 410–419, doi:10.3762/bjoc.17.37

Graphical Abstract
  • of purine [73][74][75][76] or alkylation of inosine or guanosine derivatives (Ib→II, Scheme 1) [30][36]. In the next step, azide can be introduced either by a second SNAr reaction on the C2-halo derivative or by diazotization/azidation at C2. Then, the Cu(I)-catalyzed azidealkyne cycloaddition
PDF
Album
Supp Info
Full Research Paper
Published 11 Feb 2021

1,2,3-Triazoles as leaving groups in SNAr–Arbuzov reactions: synthesis of C6-phosphonated purine derivatives

  • Kārlis-Ēriks Kriķis,
  • Irina Novosjolova,
  • Anatoly Mishnev and
  • Māris Turks

Beilstein J. Org. Chem. 2021, 17, 193–202, doi:10.3762/bjoc.17.19

Graphical Abstract
  • chlorine at the purine C2 position by azide, and 3) copper-catalyzed azidealkyne 1,3-dipolar cycloaddition (CuAAC) with different alkynes. Pathway B included: 1) the two-step synthesis of 2,6-bistriazolylpurine derivatives 6 from 2,6-dichloropurine derivative 1 [22] and 2) the SNAr–Arbuzov reaction with
PDF
Album
Supp Info
Full Research Paper
Published 20 Jan 2021

Supramolecular polymerization of sulfated dendritic peptide amphiphiles into multivalent L-selectin binders

  • David Straßburger,
  • Svenja Herziger,
  • Katharina Huth,
  • Moritz Urschbach,
  • Rainer Haag and
  • Pol Besenius

Beilstein J. Org. Chem. 2021, 17, 97–104, doi:10.3762/bjoc.17.10

Graphical Abstract
  • structures modified with sulfate groups, and their capability to interact with biological components has been demonstrated recently [31][32]. In this work, we therefore coupled dPGS to C2-symmetrical discotic peptide amphiphiles using copper-catalyzed azide alkyne cycloaddition chemistry. The evaluation of
  • , post-functionalization using a subsequent copper-catalyzed azidealkyne cycloaddition reaction became accessible [35][36]. At the same time the other two unmodified side arms of the dendritic amphiphile make sure that the fidelity of the β-sheet motifs and directed supramolecular polymerization remains
  • copper-catalyzed azidealkyne cycloaddition (Scheme 2). The reaction took place in degassed DMSO at 50 °C with CuSO4 pentahydrate, sodium ascorbate and tris(benzyltriazolylmethyl)amine (TBTA) as chelating species. HPLC-monitoring of the reaction showed a full conversion after three days and the crude
PDF
Album
Supp Info
Full Research Paper
Published 12 Jan 2021

Clickable azide-functionalized bromoarylaldehydes – synthesis and photophysical characterization

  • Dominik Göbel,
  • Marius Friedrich,
  • Enno Lork and
  • Boris J. Nachtsheim

Beilstein J. Org. Chem. 2020, 16, 1683–1692, doi:10.3762/bjoc.16.139

Graphical Abstract
  • cycloadditions with model alkynes. Besides two ortho- and para-bromo-substituted benzaldehydes, the azide functionalization of a fluorene-based structure will be presented. The copper(I)-catalyzed azidealkyne cycloaddition (CuAAC) of the so-synthesized azide-functionalized bromocarbaldehydes with terminal
  • oxazoline 24, oxazolidine 27 cyclized already during the reaction, caused by the increased basicity of the ring nitrogen. CuAAC reactions of bromocarbaldehydes We further investigated the reactivity of azide-functionalized bromocarbaldehydes 3, 4, and 5 in copper(I)-catalyzed azidealkyne cycloaddition
PDF
Album
Supp Info
Full Research Paper
Published 14 Jul 2020

Regioselectively α- and β-alkynylated BODIPY dyes via gold(I)-catalyzed direct C–H functionalization and their photophysical properties

  • Takahide Shimada,
  • Shigeki Mori,
  • Masatoshi Ishida and
  • Hiroyuki Furuta

Beilstein J. Org. Chem. 2020, 16, 587–595, doi:10.3762/bjoc.16.53

Graphical Abstract
  • -tethered BODIPY derivatives serve as a substrate in the copper-catalyzed azidealkyne cycloaddition (CuAAC) reaction, which is known as “click” reaction, allowing for a biological tissue labelling [35][36]. In addition, ethynyl-substituted BODIPYs yield unique π-conjugated BODIPY-based macrocycles by
PDF
Album
Supp Info
Full Research Paper
Published 01 Apr 2020

A systematic review on silica-, carbon-, and magnetic materials-supported copper species as efficient heterogeneous nanocatalysts in “click” reactions

  • Pezhman Shiri and
  • Jasem Aboonajmi

Beilstein J. Org. Chem. 2020, 16, 551–586, doi:10.3762/bjoc.16.52

Graphical Abstract
  • employed procedures for the creation of triazole products is the Huisgen azidealkyne cycloaddition, and the reaction selectively forms one type of triazole products. Many of the alkyne and azide substrates are commercially available, many others can easily be prepared with a good range of functional
  • . NaN3 and KI were added to the reaction mixture, and this was heated at 60 °C for two days to afford the azido-functionalized GO GO@N3 (82). In the next time, tripropargylamine (83), CuSO4, and sodium ascorbate were added to dispersed 82. The azide/alkyne “click” reaction proceeded well at rt over two
PDF
Album
Review
Published 01 Apr 2020

Photophysics and photochemistry of NIR absorbers derived from cyanines: key to new technologies based on chemistry 4.0

  • Bernd Strehmel,
  • Christian Schmitz,
  • Ceren Kütahya,
  • Yulian Pang,
  • Anke Drewitz and
  • Heinz Mustroph

Beilstein J. Org. Chem. 2020, 16, 415–444, doi:10.3762/bjoc.16.40

Graphical Abstract
PDF
Album
Supp Info
Review
Published 18 Mar 2020

Fluorinated maleimide-substituted porphyrins and chlorins: synthesis and characterization

  • Valentina A. Ol’shevskaya,
  • Elena G. Kononova and
  • Andrei V. Zaitsev

Beilstein J. Org. Chem. 2019, 15, 2704–2709, doi:10.3762/bjoc.15.263

Graphical Abstract
  • 1,2,3-triazole heterocycles via the copper-catalyzed azidealkyne cycloaddition reaction (CuAAC) between alkynes and azides, developed independently by Sharpless [41] and Meldal [42]. In addition to the applications of triazoles as pharmacophores in the potential biologically active molecules, these
PDF
Album
Supp Info
Letter
Published 13 Nov 2019
Other Beilstein-Institut Open Science Activities