Beilstein J. Org. Chem.2023,19, 736–751, doi:10.3762/bjoc.19.54
this helical aza-NG was achieved by introducing a chiral auxiliary reagent at the nitrogen site [40], and the racemization barrier of one enantiomer was measured as 26.2 kcal/mol by monitoring the changes of CD spectra at 60–80 °C. The synthesis started with the Diels−Alder reaction of 5H-dibenzo[b,f
]azepine and tetrabromothiophene-S,S-dioxide, followed by oxidative aromatization in the presence DDQ to afford compound 25 in an overall 75% yield. Suzuki−Miyaura cross-coupling reaction of compound 25 with (4-ethylphenyl)boronic acid in the presence of Pd(CH3CN)2Cl2, SPhos, and K3PO4 then furnished the
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Graphical Abstract
Scheme 1:
Construction of HBC by Scholl reaction from hexaphenylbenzene.
Beilstein J. Org. Chem.2023,19, 700–718, doi:10.3762/bjoc.19.51
David I. H. Maier Barend C. B. Bezuidenhoudt Charlene Marais Department of Chemistry, University of the Free State, PO Box 339, Bloemfontein, 9300, South Africa 10.3762/bjoc.19.51 Abstract The dibenzo[b,f]azepine skeleton is important in the pharmaceutical industry, not only in terms of existing
commercial antidepressants, anxiolytics and anticonvulsants, but also in reengineering for other applications. More recently, the potential of the dibenzo[b,f]azepine moiety in organic light emitting diodes and dye-sensitized solar cell dyes has been recognised, while catalysts and molecular organic
frameworks with dibenzo[b,f]azepine derived ligands have also been reported. This review provides a brief overview of the different synthetic strategies to dibenzo[b,f]azepines and other dibenzo[b,f]heteropines.
Keywords: dibenzo[b,f]azepine; dibenzo[b,f]heteropine; dibenzo[b,f]oxepine; iminostilbene
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Graphical Abstract
Figure 1:
Dibenzo[b,f]azepine (1a), -oxepine (1b) and -thiepine (1c) as examples of dibenzo[b,f]heteropines (1...