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Search for "hydroxypropyl-β-cyclodextrin" in Full Text gives 10 result(s) in Beilstein Journal of Organic Chemistry.

Functionalization of graphene: does the organic chemistry matter?

  • Artur Kasprzak,
  • Agnieszka Zuchowska and
  • Magdalena Poplawska

Beilstein J. Org. Chem. 2018, 14, 2018–2026, doi:10.3762/bjoc.14.177

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  • [40], it was not clear how the ester bond between RGO and hydroxypropyl-β-cyclodextrin would form, as the changes observed in the infrared spectra cannot be regarded as direct evidence for the formation of such linkages (IR analyses: C=O for carboxyl of GO: 1745 cm−1, C=O coming from ester bond stated
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Published 02 Aug 2018

Synthesis of multi-lactose-appended β-cyclodextrin and its cholesterol-lowering effects in Niemann–Pick type C disease-like HepG2 cells

  • Keiichi Motoyama,
  • Rena Nishiyama,
  • Yuki Maeda,
  • Taishi Higashi,
  • Yoichi Ishitsuka,
  • Yuki Kondo,
  • Tetsumi Irie,
  • Takumi Era and
  • Hidetoshi Arima

Beilstein J. Org. Chem. 2017, 13, 10–18, doi:10.3762/bjoc.13.2

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  • , and bioavailability of drugs. CDs improve the above properties of drugs through complex formation, when formulated as injectable solutions, sprays, eye drops, powders, and tablets [7][8]. In recent years, the efficacy of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) in the treatment of the NPC disease has
  • Niemann–Pick type C (NPC) disease, characterized by intracellular accumulation of unesterified cholesterol and other lipids owing to defects in two proteins NPC1 and NPC2, causes neurodegeneration and other fatal neurovisceral symptoms. Currently, treatment of NPC involves the use of 2-hydroxypropyl-β
  • -cyclodextrin (HP-β-CD). HP-β-CD is effective in the treatment of hepatosplenomegaly in NPC disease, albeit at a very high dose. One of the methods to reduce the required dose of HP-β-CD for treatment of NPC is to actively targeting hepatocytes with β-cyclodextrin (β-CD). The aim of the present study was to
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Published 03 Jan 2017

Stabilization of nanosized titanium dioxide by cyclodextrin polymers and its photocatalytic effect on the degradation of wastewater pollutants

  • Tamás Zoltán Agócs,
  • István Puskás,
  • Erzsébet Varga,
  • Mónika Molnár and
  • Éva Fenyvesi

Beilstein J. Org. Chem. 2016, 12, 2873–2882, doi:10.3762/bjoc.12.286

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  • how they influence the stability of nanoTiO2 in the presence of NaCl (0.1%) by recording the turbidity. We used neutral and charged CD derivatives, such as non-ionic 2-hydroxypropyl-β-cyclodextrin monomer (M) and polymer (P) (HPBCD-M/P), anionic carboxymethyl-β-cyclodextrin monomer and polymer (CMBCD
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Published 28 Dec 2016

Cross-linked cyclodextrin-based material for treatment of metals and organic substances present in industrial discharge waters

  • Élise Euvrard,
  • Nadia Morin-Crini,
  • Coline Druart,
  • Justine Bugnet,
  • Bernard Martel,
  • Cesare Cosentino,
  • Virginie Moutarlier and
  • Grégorio Crini

Beilstein J. Org. Chem. 2016, 12, 1826–1838, doi:10.3762/bjoc.12.172

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  • The cross-linked polymer (Figure 1) was prepared in a single step by crosslinking hydroxypropyl-β-cyclodextrin (HPβCD; Kleptose HPB®, DS = 0.62, Roquette, Lestrem, France) using 1,2,3,4-butanetetracarboxylic acid (BTCA; Aldrich, Milwaukee, WI). The synthesis procedure has already been described in
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Published 12 Aug 2016

Interactions between 4-thiothymidine and water-soluble cyclodextrins: Evidence for supramolecular structures in aqueous solutions

  • Vito Rizzi,
  • Sergio Matera,
  • Paola Semeraro,
  • Paola Fini and
  • Pinalysa Cosma

Beilstein J. Org. Chem. 2016, 12, 549–563, doi:10.3762/bjoc.12.54

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  • complexation mode of the inclusion complexes involving 4-thiothymidine (S4TdR, a known photosensitizer) and five CDs, namely 2-hydroxypropyl-α-cyclodextrin (2-HP-α-CD), 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD), 2-hydroxypropyl-γ-cyclodextrin (2-HP-γ-CD), heptakis-(2,6-di-O-methyl)-β-cyclodextrin (DIMEB CD
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Published 21 Mar 2016

Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann–Pick type C disease-like HepG2 cells

  • Keiichi Motoyama,
  • Yumi Hirai,
  • Rena Nishiyama,
  • Yuki Maeda,
  • Taishi Higashi,
  • Yoichi Ishitsuka,
  • Yuki Kondo,
  • Tetsumi Irie,
  • Takumi Era and
  • Hidetoshi Arima

Beilstein J. Org. Chem. 2015, 11, 2079–2086, doi:10.3762/bjoc.11.224

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  • .11.224 Abstract The Niemann–Pick type C disease (NPC) is one of inherited lysosomal storage disorders, emerges the accumulation of unesterified cholesterol in endolysosomes. Currently, 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD) has been applied for the treatment of NPC. HP-β-CyD improved
  • , etc., through complex formation [5][6]. Recently, 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD) has attracted considerable attention for the treatment of NPC disease [4][7][8][9]. The administration of HP-β-CyD to NPC1-knock out (Npc1−/−) mice has been reported to remarkably prolong the life span of the
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Published 03 Nov 2015

Cyclodextrin–polysaccharide-based, in situ-gelled system for ocular antifungal delivery

  • Anxo Fernández-Ferreiro,
  • Noelia Fernández Bargiela,
  • María Santiago Varela,
  • Maria Gil Martínez,
  • Maria Pardo,
  • Antonio Piñeiro Ces,
  • José Blanco Méndez,
  • Miguel González Barcia,
  • Maria Jesus Lamas and
  • Francisco.J. Otero-Espinar

Beilstein J. Org. Chem. 2014, 10, 2903–2911, doi:10.3762/bjoc.10.308

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  • Pharmacy, University of Santiago de Compostela (USC), Praza Seminario de Estudos Galegos s/n, Santiago de Compostela, 15701, Spain 10.3762/bjoc.10.308 Abstract Fluconazole was studied with two different hydrophilic cyclodextrins (hydroxypropyl-β-cyclodextrin (HPBCD) and sulfobutyl ether-β-cyclodextrin
  • polysaccharides gellan gum and κ-carrageenan. This system showed good bioadhesive properties and effective control of fluconazole release. Keywords: cyclodextrins; eye drops; fluconazole; hydroxypropyl-β-cyclodextrin; sulfobutylether-β-cyclodextrin; Introduction Fungal keratitis is a serious disease that can
  • -Hydroxypropyl-β-cyclodextrin (HPBCD) and sulfobutyl ether-β-cyclodextrin (SBECD) are two chemically modified cyclodextrins frequently used as vehicles to improve drug solubility. The aim of this work is to obtain an ophthalmic drug delivery system for the release of fluconazole (FC) based on the use of ion
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Published 08 Dec 2014

Improving ITC studies of cyclodextrin inclusion compounds by global analysis of conventional and non-conventional experiments

  • Eléonore Bertaut and
  • David Landy

Beilstein J. Org. Chem. 2014, 10, 2630–2641, doi:10.3762/bjoc.10.275

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  • treatment to competitive and non-competitive experiments for 1:1 Ibuprofen (IBU) complexes which are formed with β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HPβ-CD) covering temperature ranges from 283 K to 313 K. These experimental studies were used as starting points for theoretical
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Published 11 Nov 2014

Effect of cyclodextrin complexation on phenylpropanoids’ solubility and antioxidant activity

  • Miriana Kfoury,
  • David Landy,
  • Lizette Auezova,
  • Hélène Greige-Gerges and
  • Sophie Fourmentin

Beilstein J. Org. Chem. 2014, 10, 2322–2331, doi:10.3762/bjoc.10.241

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  • hydoxycinnamic acids (p-coumaric acid (5), caffeic acid (6) and ferulic acid (7)) (Figure 1) was investigated with α-CD, β-CD, hydroxypropyl-β-cyclodextrin (HP-β-CD), randomly methylated β-cyclodextrin (RAMEB) and a low methylated β-cyclodextrin (CRYSMEB). These PPs were selected mainly according to their
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Published 06 Oct 2014

Photo, thermal and chemical degradation of riboflavin

  • Muhammad Ali Sheraz,
  • Sadia Hafeez Kazi,
  • Sofia Ahmed,
  • Zubair Anwar and
  • Iqbal Ahmad

Beilstein J. Org. Chem. 2014, 10, 1999–2012, doi:10.3762/bjoc.10.208

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  • RF and β-cyclodextrin or hydroxypropyl-β-cyclodextrin at low concentrations occurred through hydrogen bonding and resulted in a better solubility of RF along with an enhanced antitumor activity [117]. On the contrary, the formation of inclusion complexes between RF and hydroxypropylated α-, β-, and γ
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Published 26 Aug 2014
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