Beilstein J. Org. Chem.2015,11, 2306–2317, doi:10.3762/bjoc.11.251
in such studies may result in ternary (host:guest:co-solvent) complex formation. The objective of this work was to investigate the effect of ethanol as a co-solvent on the inclusion complex formation between α-mangostin (α-MGS) and β-CD, using both experimental and theoretical studies. Experimental
-solvent enhances the solubility of α-MGS with some effects on the binding affinity with β-CD, depending on the concentration employed.
Keywords: α-mangostin; β-cyclodextrin; binary complex; inclusion complex; Introduction
Solubilization of otherwise poorly soluble drugs under physiological conditions to
-solvent on the complex formation between α-mangostin (α-MGS) and β-CD. Phase solubility studies were carried out in order to assess the formation of those complexes at various β-CD concentrations, with ethanol as a co-solvent. A simple mathematical model was then applied to explain the solubility of α-MGS
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Graphical Abstract
Figure 1:
Schematic views of a) β-CD and b) α-mangostin (α-MGS) geometries.