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Search for "α-mangostin" in Full Text gives 1 result(s) in Beilstein Journal of Organic Chemistry.

Co-solvation effect on the binding mode of the α-mangostin/β-cyclodextrin inclusion complex

  • Chompoonut Rungnim,
  • Sarunya Phunpee,
  • Manaschai Kunaseth,
  • Supawadee Namuangruk,
  • Kanin Rungsardthong,
  • Thanyada Rungrotmongkol and
  • Uracha Ruktanonchai

Beilstein J. Org. Chem. 2015, 11, 2306–2317, doi:10.3762/bjoc.11.251

Graphical Abstract
  • in such studies may result in ternary (host:guest:co-solvent) complex formation. The objective of this work was to investigate the effect of ethanol as a co-solvent on the inclusion complex formation between α-mangostin (α-MGS) and β-CD, using both experimental and theoretical studies. Experimental
  • -solvent enhances the solubility of α-MGS with some effects on the binding affinity with β-CD, depending on the concentration employed. Keywords: α-mangostin; β-cyclodextrin; binary complex; inclusion complex; Introduction Solubilization of otherwise poorly soluble drugs under physiological conditions to
  • -solvent on the complex formation between α-mangostin (α-MGS) and β-CD. Phase solubility studies were carried out in order to assess the formation of those complexes at various β-CD concentrations, with ethanol as a co-solvent. A simple mathematical model was then applied to explain the solubility of α-MGS
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Published 25 Nov 2015
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