Beilstein Talk on chemical glycobiology

Beilstein Talks

The Beilstein Talks are an established addition to the Beilstein-Institut’s projects supporting communication and information in science. These online talks are free to attend; a simple registration is all that is required.

Synthetic glycopeptide precision tools to reduce the complexity of protein glycosylation

Ulrika Westerlind / Umeå university
September 22, 2021,
2 - 3 pm CEST
Online live talk

Go to the free registration for the online live talk!

The myriads of protein post-translational modifications (PTMs) are major factors causing an exponential increase of complexity in the human proteome. Despite that the PTMs play key functional roles in cellular processes, the kinds of modifications, sites occupied, dynamics and interplay are far from understood. Glycosylation is one of the most abundant posttranslational modifications and is involved in many key biological events. Ulrika Wetserlind's research is focused on the development of chemistry-based tools for chemical biology studies of the human glycoproteome. Additionally her group aims to contribute to the development of therapeutic and diagnostic applications specifically centered on glycosylation events in cancer and infection biology. In this Beilstein Talk she will present the most recent research work of her group on the development of new glycoproteomic detection tools to study new tyrosine O-glycosylation PTMs and mucin type O-glycosylation. The synthesis and application of glycopeptide libraries to study the roles of fucose and sialic acid modifications in protein binding events will further be presented.

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