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Biological responses to NPs


Editor: Prof. Reinhard Zellner
Universität Duisburg-Essen

Nanoscale particles are known to exhibit novel properties that make them different from their corresponding bulk-scale materials. Concerns have been raised that the very same properties that make them interesting might also have negative health effects, which cannot easily be derived from the known toxicity of the macroscopic material. Hence, major gaps in the knowledge necessary for assessing their risk to human health currently exist. There is also a lack of existing methodologies to improve techniques for nanoparticle characterization, their detection in biological systems, as well as the biological activity of such systems. The complexity of this problem is amplified by the huge variety of nanoscale materials and potential biomolecules and cells. This special issue mostly contains mini-reviews, which summarize the current and previous work of the contributing groups performing research in this field.

 
Overview

Biological responses to nanoscale particles

Reinhard Zellner

Beilstein J. Nanotechnol. 2015, 6, 380–382. published 05 Feb 2015

Editorial

Cytotoxic and proinflammatory effects of PVP-coated silver nanoparticles after intratracheal instillation in rats

Nadine Haberl, Stephanie Hirn, Alexander Wenk, Jörg Diendorf, Matthias Epple, Blair D. Johnston, Fritz Krombach, Wolfgang G. Kreyling, Carsten Schleh

Beilstein J. Nanotechnol. 2013, 4, 933–940. published 19 Dec 2013

Full Research Paper

Injection of ligand-free gold and silver nanoparticles into murine embryos does not impact pre-implantation development

Ulrike Taylor, Wiebke Garrels, Annette Barchanski, Svea Peterson, Laszlo Sajti, Andrea Lucas-Hahn, Lisa Gamrad, Ulrich Baulain, Sabine Klein, Wilfried A. Kues, Stephan Barcikowski, Detlef Rath

Beilstein J. Nanotechnol. 2014, 5, 677–688. published 21 May 2014

Full Research Paper

Mimicking exposures to acute and lifetime concentrations of inhaled silver nanoparticles by two different in vitro approaches

Fabian Herzog, Kateryna Loza, Sandor Balog, Martin J. D. Clift, Matthias Epple, Peter Gehr, Alke Petri-Fink, Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2014, 5, 1357–1370. published 26 Aug 2014

Full Research Paper

The protein corona protects against size- and dose-dependent toxicity of amorphous silica nanoparticles

Dominic Docter, Christoph Bantz, Dana Westmeier, Hajo J. Galla, Qiangbin Wang, James C. Kirkpatrick, Peter Nielsen, Michael Maskos, Roland H. Stauber

Beilstein J. Nanotechnol. 2014, 5, 1380–1392. published 27 Aug 2014

Full Research Paper

The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver

Markus Heine, Alexander Bartelt, Oliver T. Bruns, Denise Bargheer, Artur Giemsa, Barbara Freund, Ludger Scheja, Christian Waurisch, Alexander Eychmüller, Rudolph Reimer, Horst Weller, Peter Nielsen, Joerg Heeren

Beilstein J. Nanotechnol. 2014, 5, 1432–1440. published 02 Sep 2014

Full Research Paper

In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?

Moritz Nazarenus, Qian Zhang, Mahmoud G. Soliman, Pablo del Pino, Beatriz Pelaz, Susana Carregal-Romero, Joanna Rejman, Barbara Rothen-Rutishauser, Martin J. D. Clift, Reinhard Zellner, G. Ulrich Nienhaus, James B. Delehanty, Igor L. Medintz, Wolfgang J. Parak

Beilstein J. Nanotechnol. 2014, 5, 1477–1490. published 09 Sep 2014

Review

Current state of laser synthesis of metal and alloy nanoparticles as ligand-free reference materials for nano-toxicological assays

Christoph Rehbock, Jurij Jakobi, Lisa Gamrad, Selina van der Meer, Daniela Tiedemann, Ulrike Taylor, Wilfried Kues, Detlef Rath, Stephan Barcikowski

Beilstein J. Nanotechnol. 2014, 5, 1523–1541. published 12 Sep 2014

Review

Silica nanoparticles are less toxic to human lung cells when deposited at the air–liquid interface compared to conventional submerged exposure

Alicja Panas, Andreas Comouth, Harald Saathoff, Thomas Leisner, Marco Al-Rawi, Michael Simon, Gunnar Seemann, Olaf Dössel, Sonja Mülhopt, Hanns-Rudolf Paur, Susanne Fritsch-Decker, Carsten Weiss, Silvia Diabaté

Beilstein J. Nanotechnol. 2014, 5, 1590–1602. published 19 Sep 2014

Full Research Paper

Precise quantification of silica and ceria nanoparticle uptake revealed by 3D fluorescence microscopy

Adriano A. Torrano, Christoph Bräuchle

Beilstein J. Nanotechnol. 2014, 5, 1616–1624. published 23 Sep 2014

Full Research Paper

Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages

Dagmar A. Kuhn, Dimitri Vanhecke, Benjamin Michen, Fabian Blank, Peter Gehr, Alke Petri-Fink, Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2014, 5, 1625–1636. published 24 Sep 2014

Full Research Paper

In vitro and in vivo interactions of selected nanoparticles with rodent serum proteins and their consequences in biokinetics

Wolfgang G. Kreyling, Stefanie Fertsch-Gapp, Martin Schäffler, Blair D. Johnston, Nadine Haberl, Christian Pfeiffer, Jörg Diendorf, Carsten Schleh, Stephanie Hirn, Manuela Semmler-Behnke, Matthias Epple, Wolfgang J. Parak

Beilstein J. Nanotechnol. 2014, 5, 1699–1711. published 02 Oct 2014

Review

The surface properties of nanoparticles determine the agglomeration state and the size of the particles under physiological conditions

Christoph Bantz, Olga Koshkina, Thomas Lang, Hans-Joachim Galla, C. James Kirkpatrick, Roland H. Stauber, Michael Maskos

Beilstein J. Nanotechnol. 2014, 5, 1774–1786. published 15 Oct 2014

Full Research Paper

Biocompatibility of cerium dioxide and silicon dioxide nanoparticles with endothelial cells

Claudia Strobel, Martin Förster, Ingrid Hilger

Beilstein J. Nanotechnol. 2014, 5, 1795–1807. published 17 Oct 2014

Full Research Paper

Imaging the intracellular degradation of biodegradable polymer nanoparticles

Anne-Kathrin Barthel, Martin Dass, Melanie Dröge, Jens-Michael Cramer, Daniela Baumann, Markus Urban, Katharina Landfester, Volker Mailänder, Ingo Lieberwirth

Beilstein J. Nanotechnol. 2014, 5, 1905–1917. published 29 Oct 2014

Full Research Paper

PVP-coated, negatively charged silver nanoparticles: A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments

Sebastian Ahlberg, Alexandra Antonopulos, Jörg Diendorf, Ralf Dringen, Matthias Epple, Rebekka Flöck, Wolfgang Goedecke, Christina Graf, Nadine Haberl, Jens Helmlinger, Fabian Herzog, Frederike Heuer, Stephanie Hirn, Christian Johannes, Stefanie Kittler, Manfred Köller, Katrin Korn, Wolfgang G. Kreyling, Fritz Krombach, Jürgen Lademann, Kateryna Loza, Eva M. Luther, Marcelina Malissek, Martina C. Meinke, Daniel Nordmeyer, Anne Pailliart, Jörg Raabe, Fiorenza Rancan, Barbara Rothen-Rutishauser, Eckart Rühl, Carsten Schleh, Andreas Seibel, Christina Sengstock, Lennart Treuel, Annika Vogt, Katrin Weber, Reinhard Zellner

Beilstein J. Nanotechnol. 2014, 5, 1944–1965. published 03 Nov 2014

Review

Rapid degradation of zinc oxide nanoparticles by phosphate ions

Rudolf Herrmann, F. Javier García-García, Armin Reller

Beilstein J. Nanotechnol. 2014, 5, 2007–2015. published 05 Nov 2014

Full Research Paper

Data-adaptive image-denoising for detecting and quantifying nanoparticle entry in mucosal tissues through intravital 2-photon microscopy

Torsten Bölke, Lisa Krapf, Regina Orzekowsky-Schroeder, Tobias Vossmeyer, Jelena Dimitrijevic, Horst Weller, Anna Schüth, Antje Klinger, Gereon Hüttmann, Andreas Gebert

Beilstein J. Nanotechnol. 2014, 5, 2016–2025. published 06 Nov 2014

Full Research Paper

Effects of surface functionalization on the adsorption of human serum albumin onto nanoparticles – a fluorescence correlation spectroscopy study

Pauline Maffre, Stefan Brandholt, Karin Nienhaus, Li Shang, Wolfgang J. Parak, G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2014, 5, 2036–2047. published 07 Nov 2014

Full Research Paper

Effect of silver nanoparticles on human mesenchymal stem cell differentiation

Christina Sengstock, Jörg Diendorf, Matthias Epple, Thomas A. Schildhauer, Manfred Köller

Beilstein J. Nanotechnol. 2014, 5, 2058–2069. published 10 Nov 2014

Full Research Paper

The gut wall provides an effective barrier against nanoparticle uptake

Heike Sinnecker, Thorsten Krause, Sabine Koelling, Ingmar Lautenschläger, Andreas Frey

Beilstein J. Nanotechnol. 2014, 5, 2092–2101. published 12 Nov 2014

Full Research Paper

Coating with luminal gut-constituents alters adherence of nanoparticles to intestinal epithelial cells

Heike Sinnecker, Katrin Ramaker, Andreas Frey

Beilstein J. Nanotechnol. 2014, 5, 2308–2315. published 02 Dec 2014

Full Research Paper

Inorganic Janus particles for biomedical applications

Isabel Schick, Steffen Lorenz, Dominik Gehrig, Stefan Tenzer, Wiebke Storck, Karl Fischer, Dennis Strand, Frédéric Laquai, Wolfgang Tremel

Beilstein J. Nanotechnol. 2014, 5, 2346–2362. published 05 Dec 2014

Review

Interaction of dermatologically relevant nanoparticles with skin cells and skin

Annika Vogt, Fiorenza Rancan, Sebastian Ahlberg, Berouz Nazemi, Chun Sik Choe, Maxim E. Darvin, Sabrina Hadam, Ulrike Blume-Peytavi, Kateryna Loza, Jörg Diendorf, Matthias Epple, Christina Graf, Eckart Rühl, Martina C. Meinke, Jürgen Lademann

Beilstein J. Nanotechnol. 2014, 5, 2363–2373. published 08 Dec 2014

Full Research Paper

Synthesis of radioactively labelled CdSe/CdS/ZnS quantum dots for in vivo experiments

Gordon M. Stachowski, Christoph Bauer, Christian Waurisch, Denise Bargheer, Peter Nielsen, Jörg Heeren, Stephen G. Hickey, Alexander Eychmüller

Beilstein J. Nanotechnol. 2014, 5, 2383–2387. published 10 Dec 2014

Full Research Paper

Nanoparticle interactions with live cells: Quantitative fluorescence microscopy of nanoparticle size effects

Li Shang, Karin Nienhaus, Xiue Jiang, Linxiao Yang, Katharina Landfester, Volker Mailänder, Thomas Simmet, G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2014, 5, 2388–2397. published 11 Dec 2014

Full Research Paper

Functionalized polystyrene nanoparticles as a platform for studying bio–nano interactions

Cornelia Loos, Tatiana Syrovets, Anna Musyanovych, Volker Mailänder, Katharina Landfester, G. Ulrich Nienhaus, Thomas Simmet

Beilstein J. Nanotechnol. 2014, 5, 2403–2412. published 15 Dec 2014

Review

Synthesis and characterization of fluorescence-labelled silica core-shell and noble metal-decorated ceria nanoparticles

Rudolf Herrmann, Markus Rennhak, Armin Reller

Beilstein J. Nanotechnol. 2014, 5, 2413–2423. published 16 Dec 2014

Review

Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices

Stephanie Hirn, Nadine Haberl, Kateryna Loza, Matthias Epple, Wolfgang G. Kreyling, Barbara Rothen-Rutishauser, Markus Rehberg, Fritz Krombach

Beilstein J. Nanotechnol. 2014, 5, 2440–2449. published 18 Dec 2014

Full Research Paper

Intake of silica nanoparticles by giant lipid vesicles: influence of particle size and thermodynamic membrane state

Florian G. Strobl, Florian Seitz, Christoph Westerhausen, Armin Reller, Adriano A. Torrano, Christoph Bräuchle, Achim Wixforth, Matthias F. Schneider

Beilstein J. Nanotechnol. 2014, 5, 2468–2478. published 23 Dec 2014

Full Research Paper

Mammalian cell growth on gold nanoparticle-decorated substrates is influenced by the nanoparticle coating

Christina Rosman, Sebastien Pierrat, Marco Tarantola, David Schneider, Eva Sunnick, Andreas Janshoff, Carsten Sönnichsen

Beilstein J. Nanotechnol. 2014, 5, 2479–2488. published 24 Dec 2014

Full Research Paper

The fate of a designed protein corona on nanoparticles in vitro and in vivo

Denise Bargheer, Julius Nielsen, Gabriella Gébel, Markus Heine, Sunhild C. Salmen, Roland Stauber, Horst Weller, Joerg Heeren, Peter Nielsen

Beilstein J. Nanotechnol. 2015, 6, 36–46. published 06 Jan 2015

Full Research Paper

The distribution and degradation of radiolabeled superparamagnetic iron oxide nanoparticles and quantum dots in mice

Denise Bargheer, Artur Giemsa, Barbara Freund, Markus Heine, Christian Waurisch, Gordon M. Stachowski, Stephen G. Hickey, Alexander Eychmüller, Jörg Heeren, Peter Nielsen

Beilstein J. Nanotechnol. 2015, 6, 111–123. published 09 Jan 2015

Full Research Paper

Caveolin-1 and CDC42 mediated endocytosis of silica-coated iron oxide nanoparticles in HeLa cells

Nils Bohmer, Andreas Jordan

Beilstein J. Nanotechnol. 2015, 6, 167–176. published 14 Jan 2015

Full Research Paper

Mechanical properties of MDCK II cells exposed to gold nanorods

Anna Pietuch, Bastian Rouven Brückner, David Schneider, Marco Tarantola, Christina Rosman, Carsten Sönnichsen, Andreas Janshoff

Beilstein J. Nanotechnol. 2015, 6, 223–231. published 20 Jan 2015

Full Research Paper

Tailoring the ligand shell for the control of cellular uptake and optical properties of nanocrystals

Johannes Ostermann, Christian Schmidtke, Christopher Wolter, Jan-Philip Merkl, Hauke Kloust, Horst Weller

Beilstein J. Nanotechnol. 2015, 6, 232–242. published 21 Jan 2015

Review

Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques

Anja Ostrowski, Daniel Nordmeyer, Alexander Boreham, Cornelia Holzhausen, Lars Mundhenk, Christina Graf, Martina C. Meinke, Annika Vogt, Sabrina Hadam, Jürgen Lademann, Eckart Rühl, Ulrike Alexiev, Achim D. Gruber

Beilstein J. Nanotechnol. 2015, 6, 263–280. published 23 Jan 2015

Review

The effect of surface charge on nonspecific uptake and cytotoxicity of CdSe/ZnS core/shell quantum dots

Vladimir V. Breus, Anna Pietuch, Marco Tarantola, Thomas Basché, Andreas Janshoff

Beilstein J. Nanotechnol. 2015, 6, 281–292. published 26 Jan 2015

Full Research Paper

Comparative evaluation of the impact on endothelial cells induced by different nanoparticle structures and functionalization

Lisa Landgraf, Ines Müller, Peter Ernst, Miriam Schäfer, Christina Rosman, Isabel Schick, Oskar Köhler, Hartmut Oehring, Vladimir V. Breus, Thomas Basché, Carsten Sönnichsen, Wolfgang Tremel, Ingrid Hilger

Beilstein J. Nanotechnol. 2015, 6, 300–312. published 27 Jan 2015

Full Research Paper

Hematopoietic and mesenchymal stem cells: polymeric nanoparticle uptake and lineage differentiation

Ivonne Brüstle, Thomas Simmet, Gerd Ulrich Nienhaus, Katharina Landfester, Volker Mailänder

Beilstein J. Nanotechnol. 2015, 6, 383–395. published 05 Feb 2015

Full Research Paper

A surface acoustic wave-driven micropump for particle uptake investigation under physiological flow conditions in very small volumes

Florian G. Strobl, Dominik Breyer, Phillip Link, Adriano A. Torrano, Christoph Bräuchle, Matthias F. Schneider, Achim Wixforth

Beilstein J. Nanotechnol. 2015, 6, 414–419. published 09 Feb 2015

Full Research Paper

Pulmonary surfactant augments cytotoxicity of silica nanoparticles: Studies on an in vitro air–blood barrier model

Jennifer Y. Kasper, Lisa Feiden, Maria I. Hermanns, Christoph Bantz, Michael Maskos, Ronald E. Unger, C. James Kirkpatrick

Beilstein J. Nanotechnol. 2015, 6, 517–528. published 20 Feb 2015

Full Research Paper

Influence of gold, silver and gold–silver alloy nanoparticles on germ cell function and embryo development

Ulrike Taylor, Daniela Tiedemann, Christoph Rehbock, Wilfried A. Kues, Stephan Barcikowski, Detlef Rath

Beilstein J. Nanotechnol. 2015, 6, 651–664. published 05 Mar 2015

Full Research Paper

Protein corona – from molecular adsorption to physiological complexity

Lennart Treuel, Dominic Docter, Michael Maskos, Roland H. Stauber

Beilstein J. Nanotechnol. 2015, 6, 857–873. published 30 Mar 2015

Review