An improved preparation of phorbol from croton oil

Scholarly Works

• Maioli, C.; Amin, H. I. M.; Chianese, G.; Minassi, A.; Reddell, P. W.; Gaeta, S.; Taglialatela-Scafati, O.; Appendino, G. Novel Skeletal Rearrangements of the Tigliane Diterpenoid Core. Journal of natural products 2023, 86, 2685–2690. doi:10.1021/acs.jnatprod.3c00834
• Fan, J.-P.; He, B.-T.; Gao, Y.; Xie, C.-F.; Chen, H.-P.; Peng, H.-L. Biphasic alcoholysis coupled with high-speed countercurrent chromatography for high performance on separating phorbol from Croton tiglium Linn extracts. Journal of separation science 2023, 46, e2200984. doi:10.1002/jssc.202200984
• Negi, P.; Agarwal, S.; Garg, P.; Ali, A.; Kulshrestha, S. In vivo models of understanding inflammation (in vivo methods for inflammation). Recent Developments in Anti-Inflammatory Therapy; Elsevier, 2023; pp 315–330. doi:10.1016/b978-0-323-99988-5.00017-6
• Wender, P. A.; Gentry, Z. O.; Fanelli, D. J.; Luu-Nguyen, Q. H.; McAteer, O. D.; Njoo, E. Practical synthesis of the therapeutic leads tigilanol tiglate and its analogues. Nature chemistry 2022, 14, 1421–1426. doi:10.1038/s41557-022-01048-2
• Damascena, H. L.; Silveira, W. A. A.; Castro, M. S.; Fontes, W. Neutrophil Activated by the Famous and Potent PMA (Phorbol Myristate Acetate). Cells 2022, 11, 2889. doi:10.3390/cells11182889
• Chianese, G.; Amin, H. I. M.; Maioli, C.; Reddell, P.; Parsons, P.; Cullen, J.; Johns, J.; Handoko, H.; Boyle, G.; Appendino, G.; Taglialatela-Scafati, O.; Gaeta, S. Cryptic Epoxytiglianes from the Kernels of the Blushwood Tree (Fontainea picrosperma). Journal of natural products 2022, 85, 1959–1966. doi:10.1021/acs.jnatprod.2c00226
• Zhang, T.; Liu, Z.; Sun, X.; Liu, Z.; Zhang, L.; Zhang, Q.; Peng, W.; Wu, C. Botany, traditional uses, phytochemistry, pharmacological and toxicological effects of Croton tiglium Linn.: a comprehensive review. The Journal of pharmacy and pharmacology 2022, 74, 1061–1084. doi:10.1093/jpp/rgac040
• Williams, C. M.; Dallaston, M. A. The Future of Retrosynthesis and Synthetic Planning: Algorithmic, Humanistic or the Interplay?. Australian Journal of Chemistry 2021, 74, 291–326. doi:10.1071/ch20371
• Chow, S.; Krainz, T.; Bettencourt, C. J.; Broit, N.; Ferguson, B.; Zhu, M.; Hull, K. G.; Pierens, G. K.; Bernhardt, P. V.; Parsons, P. G.; Romo, D.; Boyle, G. M.; Williams, C. M. Synthetic Tigliane Intermediates Engage Thiols to Induce Potent Cell Line Selective Anti-Cancer Activity. Chemistry (Weinheim an der Bergstrasse, Germany) 2020, 26, 13372–13377. doi:10.1002/chem.202003221
• Herbrechter, R.; Beltrán, L.; Ziemba, P. M.; Titt, S.; Lashuk, K.; Gottemeyer, A.; Levermann, J.; Hoffmann, K. M.; Beltran, M.; Hatt, H.; Störtkuhl, K. F.; Werner, M.; Gisselmann, G. Effect of 158 herbal remedies on human TRPV1 and the two-pore domain potassium channels KCNK2, 3 and 9. Journal of traditional and complementary medicine 2020, 10, 446–453. doi:10.1016/j.jtcme.2020.04.005
• Chow, S.; Krainz, T.; Bernhardt, P. V.; Williams, C. M. En Route to D-Ring Inverted Phorbol Esters. Organic letters 2019, 21, 8761–8764. doi:10.1021/acs.orglett.9b03379
• Zimmermann, T.; Franzyk, H.; Christensen, S. B. Phorbol Rearrangements. Journal of natural products 2018, 81, 2134–2137. doi:10.1021/acs.jnatprod.8b00607

Explore citations to this article at