Lipids: fatty acids and derivatives, polyketides and isoprenoids

  1. editorImage
  1. Editor: Prof. Jeroen S. Dickschat
    Universität Bonn

Lipids fulfill various functions in life as membrane constituents, for energy storage, or as signaling molecules. If the human lipid metabolism is disturbed, this may lead to serious illnesses such as adipositas and its subsequent complications including cardiovascular diseases or diabetes mellitus. Other consequences of a disordered lipid metabolism include brain dysfunctions, especially if the sphingolipid metabolism is affected, which can often be related to a specific genetic mutation. Sensu stricto, lipids are defined as apolar natural products that can be classified as fatty acids, whose derivatives are waxes, triacylglycerides, phospholipids, sphingolipids and glycolipids. Lipids also constitute important post-translational protein modifications in lipoproteins. The amphiphilic nature of compounds such as phospholipids with a polar headgroup and a long apolar chain results in the spontaneous formation of lipid bilayers in aqueous environments. This was likely a crucial process for the origin of life – and certainly still is for all existing living systems that necessarily contain lipid membranes with their interesting and finely balanced biophysical properties.

Further articles will be published during the next weeks.

See also the Thematic Series:
Natural products in synthesis and biosynthesis II
Transition-metal and organocatalysis in natural product synthesis
Biosynthesis and function of secondary metabolites

  • Editorial
  • Published 27 Apr 2017

Beilstein J. Org. Chem. 2017, 13, 793–794, doi:10.3762/bjoc.13.78

Identification, synthesis and mass spectrometry of a macrolide from the African reed frog Hyperolius cinnamomeoventris

  1. Markus Menke,
  2. Pardha Saradhi Peram,
  3. Iris Starnberger,
  4. Walter Hödl,
  5. Gregory F.M. Jongsma,
  6. David C. Blackburn,
  7. Mark-Oliver Rödel,
  8. Miguel Vences and
  9. Stefan Schulz
  • Full Research Paper
  • Published 13 Dec 2016

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Beilstein J. Org. Chem. 2016, 12, 2731–2738, doi:10.3762/bjoc.12.269

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  • Published 14 Dec 2016

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Beilstein J. Org. Chem. 2016, 12, 2739–2747, doi:10.3762/bjoc.12.270

Synthesis and evaluation of anti-oxidant and cytotoxic activities of novel 10-undecenoic acid methyl ester based lipoconjugates of phenolic acids

  1. Naganna Narra,
  2. Shiva Shanker Kaki,
  3. Rachapudi Badari Narayana Prasad,
  4. Sunil Misra,
  5. Koude Dhevendar,
  6. Venkateshwarlu Kontham and
  7. Padmaja V. Korlipara
  • Full Research Paper
  • Published 04 Jan 2017

Beilstein J. Org. Chem. 2017, 13, 26–32, doi:10.3762/bjoc.13.4

Posttranslational isoprenylation of tryptophan in bacteria

  1. Masahiro Okada,
  2. Tomotoshi Sugita and
  3. Ikuro Abe
  • Review
  • Published 22 Feb 2017

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Beilstein J. Org. Chem. 2017, 13, 338–346, doi:10.3762/bjoc.13.37

  • Full Research Paper
  • Published 08 Mar 2017

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Beilstein J. Org. Chem. 2017, 13, 441–450, doi:10.3762/bjoc.13.47

Secondary metabolome and its defensive role in the aeolidoidean Phyllodesmium longicirrum, (Gastropoda, Heterobranchia, Nudibranchia)

  1. Alexander Bogdanov,
  2. Cora Hertzer,
  3. Stefan Kehraus,
  4. Samuel Nietzer,
  5. Sven Rohde,
  6. Peter J. Schupp,
  7. Heike Wägele and
  8. Gabriele M. König
  • Full Research Paper
  • Published 13 Mar 2017

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Beilstein J. Org. Chem. 2017, 13, 502–519, doi:10.3762/bjoc.13.50

Membrane properties of hydroxycholesterols related to the brain cholesterol metabolism

  1. Malte Hilsch,
  2. Ivan Haralampiev,
  3. Peter Müller,
  4. Daniel Huster and
  5. Holger A. Scheidt
  • Full Research Paper
  • Published 18 Apr 2017

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Beilstein J. Org. Chem. 2017, 13, 720–727, doi:10.3762/bjoc.13.71

  • Review
  • Published 08 May 2017

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Beilstein J. Org. Chem. 2017, 13, 845–854, doi:10.3762/bjoc.13.85

Aggregation behaviour of a single-chain, phenylene-modified bolalipid and its miscibility with classical phospholipids

  1. Simon Drescher,
  2. Vasil M. Garamus,
  3. Christopher J. Garvey,
  4. Annette Meister and
  5. Alfred Blume
  • Full Research Paper
  • Published 23 May 2017

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Beilstein J. Org. Chem. 2017, 13, 995–1007, doi:10.3762/bjoc.13.99

  • Review
  • Published 07 Jun 2017

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Beilstein J. Org. Chem. 2017, 13, 1085–1098, doi:10.3762/bjoc.13.108

Correlation of surface pressure and hue of planarizable push–pull chromophores at the air/water interface

  1. Frederik Neuhaus,
  2. Fabio Zobi,
  3. Gerald Brezesinski,
  4. Marta Dal Molin,
  5. Stefan Matile and
  6. Andreas Zumbuehl
  • Full Research Paper
  • Published 08 Jun 2017

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Beilstein J. Org. Chem. 2017, 13, 1099–1105, doi:10.3762/bjoc.13.109

  • Review
  • Published 21 Jun 2017

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Beilstein J. Org. Chem. 2017, 13, 1204–1211, doi:10.3762/bjoc.13.119

Total synthesis of elansolids B1 and B2

  1. Liang-Liang Wang and
  2. Andreas Kirschning
  • Full Research Paper
  • Published 28 Jun 2017

Beilstein J. Org. Chem. 2017, 13, 1280–1287, doi:10.3762/bjoc.13.124

BODIPY-based fluorescent liposomes with sesquiterpene lactone trilobolide

  1. Ludmila Škorpilová,
  2. Silvie Rimpelová,
  3. Michal Jurášek,
  4. Miloš Buděšínský,
  5. Jana Lokajová,
  6. Roman Effenberg,
  7. Petr Slepička,
  8. Tomáš Ruml,
  9. Eva Kmoníčková,
  10. Pavel B. Drašar and
  11. Zdeněk Wimmer
  • Full Research Paper
  • Published 04 Jul 2017

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Beilstein J. Org. Chem. 2017, 13, 1316–1324, doi:10.3762/bjoc.13.128

An improved preparation of phorbol from croton oil

  1. Alberto Pagani,
  2. Simone Gaeta,
  3. Andrei I. Savchenko,
  4. Craig M. Williams and
  5. Giovanni Appendino
  • Full Research Paper
  • Published 11 Jul 2017

Beilstein J. Org. Chem. 2017, 13, 1361–1367, doi:10.3762/bjoc.13.133

A new member of the fusaricidin family – structure elucidation and synthesis of fusaricidin E

  1. Marcel Reimann,
  2. Louis P. Sandjo,
  3. Luis Antelo,
  4. Eckhard Thines,
  5. Isabella Siepe and
  6. Till Opatz
  • Full Research Paper
  • Published 20 Jul 2017

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Beilstein J. Org. Chem. 2017, 13, 1430–1438, doi:10.3762/bjoc.13.140

The chemistry and biology of mycolactones

  1. Matthias Gehringer and
  2. Karl-Heinz Altmann
  • Review
  • Published 11 Aug 2017

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Beilstein J. Org. Chem. 2017, 13, 1596–1660, doi:10.3762/bjoc.13.159

18-Hydroxydolabella-3,7-diene synthase – a diterpene synthase from Chitinophaga pinensis

  1. Jeroen S. Dickschat,
  2. Jan Rinkel,
  3. Patrick Rabe,
  4. Arman Beyraghdar Kashkooli and
  5. Harro J. Bouwmeester
  • Full Research Paper
  • Published 23 Aug 2017

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Beilstein J. Org. Chem. 2017, 13, 1770–1780, doi:10.3762/bjoc.13.171

Sulfation and amidinohydrolysis in the biosynthesis of giant linear polyenes

  1. Hui Hong,
  2. Markiyan Samborskyy,
  3. Katsiaryna Usachova,
  4. Katharina Schnatz and
  5. Peter F. Leadlay
  • Full Research Paper
  • Published 13 Nov 2017

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  • Supp. Info

Beilstein J. Org. Chem. 2017, 13, 2408–2415, doi:10.3762/bjoc.13.238

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