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Beilstein Organic Chemistry Symposium 2015

Multicomponent reactions

Editor: Prof. Thomas J. J. Müller
Heinrich-Heine-Universität Düsseldorf

Chemistry as a central science is facing a steadily increasing demand for new chemical entities. Innovative solutions, in all kinds of disciplines that depend on chemistry, require new molecules with specific properties, and their societal consequences are fundamental and pioneering. However, these molecules not only demand a realistic structural space but also their feasibility poses challenges to synthetic chemists. Nowadays the question of how to perform a synthesis has become most crucial. In particular multicomponent reactions are masterpieces of synthetic efficiency and reaction design. These one-pot processes consist of concatenations of elementary organic reactions under similar conditions.


Multicomponent reactions

Thomas J. J. Müller

Beilstein J. Org. Chem. 2011, 7, 960–961. published 13 Jul 2011


A practical two-step procedure for the preparation of enantiopure pyridines: Multicomponent reactions of alkoxyallenes, nitriles and carboxylic acids followed by a cyclocondensation reaction

Christian Eidamshaus, Roopender Kumar, Mrinal K. Bera, Hans-Ulrich Reissig

Beilstein J. Org. Chem. 2011, 7, 962–975. published 13 Jul 2011

Full Research Paper

Long-range diastereoselectivity in Ugi reactions of 2-substituted dihydrobenzoxazepines

Luca Banfi, Andrea Basso, Valentina Cerulli, Valeria Rocca, Renata Riva

Beilstein J. Org. Chem. 2011, 7, 976–979. published 13 Jul 2011