These Thematic Series are open for submission: (1) Lipids; (2) Chemical biology

Submission is open for “Spatial Effects in Polymers” and "Porous Materials"

The 2015 Impact Factor is 2.697 according to the Thomson Reuters Journal Citation Reports.

Open Access 2020 is an initiative to induce the transformation from subscription to open access publishing.

Confirming exceptionally high level of publishing standards

Multicomponent reactions

Editor: Prof. Thomas J. J. Müller
Heinrich-Heine-Universität Düsseldorf

Chemistry as a central science is facing a steadily increasing demand for new chemical entities. Innovative solutions, in all kinds of disciplines that depend on chemistry, require new molecules with specific properties, and their societal consequences are fundamental and pioneering. However, these molecules not only demand a realistic structural space but also their feasibility poses challenges to synthetic chemists. Nowadays the question of how to perform a synthesis has become most crucial. In particular multicomponent reactions are masterpieces of synthetic efficiency and reaction design. These one-pot processes consist of concatenations of elementary organic reactions under similar conditions.

See also the Thematic Series:
Multicomponent reactions II


Multicomponent reactions

Thomas J. J. Müller

Beilstein J. Org. Chem. 2011, 7, 960–961. published 13 Jul 2011


A practical two-step procedure for the preparation of enantiopure pyridines: Multicomponent reactions of alkoxyallenes, nitriles and carboxylic acids followed by a cyclocondensation reaction

Christian Eidamshaus, Roopender Kumar, Mrinal K. Bera, Hans-Ulrich Reissig

Beilstein J. Org. Chem. 2011, 7, 962–975. published 13 Jul 2011

Full Research Paper

Long-range diastereoselectivity in Ugi reactions of 2-substituted dihydrobenzoxazepines

Luca Banfi, Andrea Basso, Valentina Cerulli, Valeria Rocca, Renata Riva

Beilstein J. Org. Chem. 2011, 7, 976–979. published 13 Jul 2011


Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts

Esther Vicente-García, Rosario Ramón, Sara Preciado, Rodolfo Lavilla

Beilstein J. Org. Chem. 2011, 7, 980–987. published 13 Jul 2011

Full Research Paper

A practical route to tertiary diarylmethylamides or -carbamates from imines, organozinc reagents and acyl chlorides or chloroformates

Erwan Le Gall, Antoine Pignon, Thierry Martens

Beilstein J. Org. Chem. 2011, 7, 997–1002. published 20 Jul 2011


Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation

Jingjing Wu, Hui Li, Song Cao

Beilstein J. Org. Chem. 2011, 7, 1070–1074. published 08 Aug 2011

Full Research Paper

Multicomponent synthesis of artificial nucleases and their RNase and DNase activity

Anton V. Gulevich, Lyudmila S. Koroleva, Olga V. Morozova, Valentina N. Bakhvalova, Vladimir N. Silnikov, Valentine G. Nenajdenko

Beilstein J. Org. Chem. 2011, 7, 1135–1140. published 19 Aug 2011

Full Research Paper

One-pot four-component synthesis of pyrimidyl and pyrazolyl substituted azulenes by glyoxylation–decarbonylative alkynylation–cyclocondensation sequences

Charlotte F. Gers, Julia Rosellen, Eugen Merkul, Thomas J. J. Müller

Beilstein J. Org. Chem. 2011, 7, 1173–1181. published 26 Aug 2011

Full Research Paper

Synthesis of diverse dihydropyrimidine-related scaffolds by fluorous benzaldehyde-based Biginelli reaction and post-condensation modifications

Bruno Piqani, Wei Zhang

Beilstein J. Org. Chem. 2011, 7, 1294–1298. published 16 Sep 2011


A straightforward approach towards combined α-amino and α-hydroxy acids based on Passerini reactions

Ameer F. Zahoor, Sarah Thies, Uli Kazmaier

Beilstein J. Org. Chem. 2011, 7, 1299–1303. published 19 Sep 2011

Full Research Paper

Ugi post-condensation copper-triggered oxidative cascade towards pyrazoles

Aurélie Dos Santos, Laurent El Kaim, Laurence Grimaud, Caroline Ronsseray

Beilstein J. Org. Chem. 2011, 7, 1310–1314. published 21 Sep 2011


Amines as key building blocks in Pd-assisted multicomponent processes

Didier Bouyssi, Nuno Monteiro, Geneviève Balme

Beilstein J. Org. Chem. 2011, 7, 1387–1406. published 10 Oct 2011


Pseudo five-component synthesis of 2,5-di(hetero)arylthiophenes via a one-pot Sonogashira–Glaser cyclization sequence

Dominik Urselmann, Dragutin Antovic, Thomas J. J. Müller

Beilstein J. Org. Chem. 2011, 7, 1499–1503. published 04 Nov 2011

Full Research Paper

Synthesis of (−)-julocrotine and a diversity oriented Ugi-approach to analogues and probes

Ricardo A. W. Neves Filho, Bernhard Westermann, Ludger A. Wessjohann

Beilstein J. Org. Chem. 2011, 7, 1504–1507. published 07 Nov 2011

Full Research Paper

Regioselectivity in the multicomponent reaction of 5-aminopyrazoles, cyclic 1,3-diketones and dimethylformamide dimethylacetal under controlled microwave heating

Kamal Usef Sadek, Ramadan Ahmed Mekheimer, Tahany Mahmoud Mohamed, Moustafa Sherief Moustafa, Mohamed Hilmy Elnagdi

Beilstein J. Org. Chem. 2012, 8, 18–24. published 04 Jan 2012

Full Research Paper