Multicomponent reactions II

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Editor: Prof. Thomas J. J. Müller
Heinrich-Heine-Universität Düsseldorf
 
This Thematic Series on multicomponent reactions (MCR) is a continuation of the previously released series two years ago and again presents a snap shot of this highly dynamic field. With the traditional formats of letters, full papers, and reviews it spans the broad range of modern chemistry, including organocatalytic, organometallic, transition metal-catalyzed, radical reactions, condensation and isonitrile-based MCR. Biologically active compounds and photonic properties are addressed as well as mechanistic studies and models. MCR are intriguing for industrial applications, but they are also challenging for academia, in particular for the minute and sophisticated fine-tuning of reactivity and selectivity, which is required to concatenate elementary steps to novel sequences. The interested reader – whether an expert in the field or a newcomer – will find exciting reports from the current realm of MCR chemistry.
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Multicomponent reactions II

  • Thomas J. J. Müller

Beilstein J. Org. Chem. 2014, 10, 115–116, doi:10.3762/bjoc.10.7

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Published 09 Jan 2014

Post-Ugi gold-catalyzed diastereoselective domino cyclization for the synthesis of diversely substituted spiroindolines

  • Amit Kumar,
  • Dipak D. Vachhani,
  • Sachin G. Modha,
  • Sunil K. Sharma,
  • Virinder S. Parmar and
  • Erik V. Van der Eycken

Beilstein J. Org. Chem. 2013, 9, 2097–2102, doi:10.3762/bjoc.9.246

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Published 14 Oct 2013

Efficient synthesis of dihydropyrimidinones via a three-component Biginelli-type reaction of urea, alkylaldehyde and arylaldehyde

  • Haijun Qu,
  • Xuejian Li,
  • Fan Mo and
  • Xufeng Lin

Beilstein J. Org. Chem. 2013, 9, 2846–2851, doi:10.3762/bjoc.9.320

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Published 11 Dec 2013

Four-component reaction of cyclic amines, 2-aminobenzothiazole, aromatic aldehydes and acetylenedicarboxylate

  • Hong Gao,
  • Jing Sun and
  • Chao-Guo Yan

Beilstein J. Org. Chem. 2013, 9, 2934–2939, doi:10.3762/bjoc.9.330

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Published 27 Dec 2013

Studies on the interaction of isocyanides with imines: reaction scope and mechanistic variations

  • Ouldouz Ghashghaei,
  • Consiglia Annamaria Manna,
  • Esther Vicente-García,
  • Marc Revés and
  • Rodolfo Lavilla

Beilstein J. Org. Chem. 2014, 10, 12–17, doi:10.3762/bjoc.10.3

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Letter
Published 06 Jan 2014

The regioselective synthesis of spirooxindolo pyrrolidines and pyrrolizidines via three-component reactions of acrylamides and aroylacrylic acids with isatins and α-amino acids

  • Tatyana L. Pavlovskaya,
  • Fedor G. Yaremenko,
  • Victoria V. Lipson,
  • Svetlana V. Shishkina,
  • Oleg V. Shishkin,
  • Vladimir I. Musatov and
  • Alexander S. Karpenko

Beilstein J. Org. Chem. 2014, 10, 117–126, doi:10.3762/bjoc.10.8

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Published 09 Jan 2014

Organobase-catalyzed three-component reactions for the synthesis of 4H-2-aminopyrans, condensed pyrans and polysubstituted benzenes

  • Moustafa Sherief Moustafa,
  • Saleh Mohammed Al-Mousawi,
  • Maghraby Ali Selim,
  • Ahmed Mohamed Mosallam and
  • Mohamed Hilmy Elnagdi

Beilstein J. Org. Chem. 2014, 10, 141–149, doi:10.3762/bjoc.10.11

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Published 14 Jan 2014

One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions

  • Shuhei Sumino,
  • Akira Fusano,
  • Hiroyuki Okai,
  • Takahide Fukuyama and
  • Ilhyong Ryu

Beilstein J. Org. Chem. 2014, 10, 150–154, doi:10.3762/bjoc.10.12

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Published 14 Jan 2014

Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues

  • Nadezhda V. Sokolova,
  • Valentine G. Nenajdenko,
  • Vladimir B. Sokolov,
  • Daria V. Vinogradova,
  • Elena F. Shevtsova,
  • Ludmila G. Dubova and
  • Sergey O. Bachurin

Beilstein J. Org. Chem. 2014, 10, 155–162, doi:10.3762/bjoc.10.13

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Published 15 Jan 2014

Diversity-oriented synthesis of dihydrobenzoxazepinones by coupling the Ugi multicomponent reaction with a Mitsunobu cyclization

  • Lisa Moni,
  • Luca Banfi,
  • Andrea Basso,
  • Alice Brambilla and
  • Renata Riva

Beilstein J. Org. Chem. 2014, 10, 209–212, doi:10.3762/bjoc.10.16

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Letter
Published 17 Jan 2014

Boron-substituted 1,3-dienes and heterodienes as key elements in multicomponent processes

  • Ludovic Eberlin,
  • Fabien Tripoteau,
  • François Carreaux,
  • Andrew Whiting and
  • Bertrand Carboni

Beilstein J. Org. Chem. 2014, 10, 237–250, doi:10.3762/bjoc.10.19

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Published 22 Jan 2014

Secondary amine-initiated three-component synthesis of 3,4-dihydropyrimidinones and thiones involving alkynes, aldehydes and thiourea/urea

  • Jie-Ping Wan,
  • Yunfang Lin,
  • Kaikai Hu and
  • Yunyun Liu

Beilstein J. Org. Chem. 2014, 10, 287–292, doi:10.3762/bjoc.10.25

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Published 29 Jan 2014

The Flögel-three-component reaction with dicarboxylic acids – an approach to bis(β-alkoxy-β-ketoenamides) for the synthesis of complex pyridine and pyrimidine derivatives

  • Mrinal K. Bera,
  • Moisés Domínguez,
  • Paul Hommes and
  • Hans-Ulrich Reissig

Beilstein J. Org. Chem. 2014, 10, 394–404, doi:10.3762/bjoc.10.37

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Published 13 Feb 2014

A new manganese-mediated, cobalt-catalyzed three-component synthesis of (diarylmethyl)sulfonamides

  • Antoine Pignon,
  • Erwan Le Gall and
  • Thierry Martens

Beilstein J. Org. Chem. 2014, 10, 425–431, doi:10.3762/bjoc.10.39

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Published 17 Feb 2014

A catalyst-free multicomponent domino sequence for the diastereoselective synthesis of (E)-3-[2-arylcarbonyl-3-(arylamino)allyl]chromen-4-ones

  • Pitchaimani Prasanna,
  • Pethaiah Gunasekaran,
  • Subbu Perumal and
  • J. Carlos Menéndez

Beilstein J. Org. Chem. 2014, 10, 459–465, doi:10.3762/bjoc.10.43

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Published 21 Feb 2014

Silver and gold-catalyzed multicomponent reactions

  • Giorgio Abbiati and
  • Elisabetta Rossi

Beilstein J. Org. Chem. 2014, 10, 481–513, doi:10.3762/bjoc.10.46

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Published 26 Feb 2014

Zirconoarylation of alkynes through p-chloranil-promoted reductive elimination of arylzirconates

  • Xiaoyu Yan,
  • Chao Chen and
  • Chanjuan Xi

Beilstein J. Org. Chem. 2014, 10, 528–534, doi:10.3762/bjoc.10.48

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Published 28 Feb 2014

Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics

  • Gijs Koopmanschap,
  • Eelco Ruijter and
  • Romano V.A. Orru

Beilstein J. Org. Chem. 2014, 10, 544–598, doi:10.3762/bjoc.10.50

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Published 04 Mar 2014

One-pot three-component synthesis and photophysical characteristics of novel triene merocyanines

  • Christian Muschelknautz,
  • Robin Visse,
  • Jan Nordmann and
  • Thomas J. J. Müller

Beilstein J. Org. Chem. 2014, 10, 599–612, doi:10.3762/bjoc.10.51

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Published 05 Mar 2014

Rapid pseudo five-component synthesis of intensively blue luminescent 2,5-di(hetero)arylfurans via a Sonogashira–Glaser cyclization sequence

  • Fabian Klukas,
  • Alexander Grunwald,
  • Franziska Menschel and
  • Thomas J. J. Müller

Beilstein J. Org. Chem. 2014, 10, 672–679, doi:10.3762/bjoc.10.60

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Published 18 Mar 2014

The Ugi four-component reaction as a concise modular synthetic tool for photo-induced electron transfer donor-anthraquinone dyads

  • Sarah Bay,
  • Gamall Makhloufi,
  • Christoph Janiak and
  • Thomas J. J. Müller

Beilstein J. Org. Chem. 2014, 10, 1006–1016, doi:10.3762/bjoc.10.100

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Published 05 May 2014

Consecutive isocyanide-based multicomponent reactions: synthesis of cyclic pentadepsipeptoids

  • Angélica de Fátima S. Barreto,
  • Otilie E. Vercillo,
  • Ludger A. Wessjohann and
  • Carlos Kleber Z. Andrade

Beilstein J. Org. Chem. 2014, 10, 1017–1022, doi:10.3762/bjoc.10.101

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Published 05 May 2014

Microwave-assisted Cu(I)-catalyzed, three-component synthesis of 2-(4-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-1H-benzo[d]imidazoles

  • Yogesh Kumar,
  • Vijay Bahadur,
  • Anil K. Singh,
  • Virinder S. Parmar,
  • Erik V. Van der Eycken and
  • Brajendra K. Singh

Beilstein J. Org. Chem. 2014, 10, 1413–1420, doi:10.3762/bjoc.10.145

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Published 24 Jun 2014

Multicomponent reactions in nucleoside chemistry

  • Mariola Koszytkowska-Stawińska and
  • Włodzimierz Buchowicz

Beilstein J. Org. Chem. 2014, 10, 1706–1732, doi:10.3762/bjoc.10.179

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Published 29 Jul 2014

Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines – sequential versus multicomponent reaction approach

  • Barbara Palka,
  • Angela Di Capua,
  • Maurizio Anzini,
  • Gyté Vilkauskaité,
  • Algirdas Šačkus and
  • Wolfgang Holzer

Beilstein J. Org. Chem. 2014, 10, 1759–1764, doi:10.3762/bjoc.10.183

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Published 31 Jul 2014

Facile synthesis of 1H-imidazo[1,2-b]pyrazoles via a sequential one-pot synthetic approach

  • András Demjén,
  • Márió Gyuris,
  • János Wölfling,
  • László G. Puskás and
  • Iván Kanizsai

Beilstein J. Org. Chem. 2014, 10, 2338–2344, doi:10.3762/bjoc.10.243

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Published 08 Oct 2014

New highlights of the syntheses of pyrrolo[1,2-a]quinoxalin-4-ones

  • Emilian Georgescu,
  • Alina Nicolescu,
  • Florentina Georgescu,
  • Florina Teodorescu,
  • Daniela Marinescu,
  • Ana-Maria Macsim and
  • Calin Deleanu

Beilstein J. Org. Chem. 2014, 10, 2377–2387, doi:10.3762/bjoc.10.248

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Published 14 Oct 2014

One-pot four-component reaction for convenient synthesis of functionalized 1-benzamidospiro[indoline-3,4'-pyridines]

  • Chao Wang,
  • Yan-Hong Jiang and
  • Chao-Guo Yan

Beilstein J. Org. Chem. 2014, 10, 2671–2676, doi:10.3762/bjoc.10.281

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Published 14 Nov 2014

The unexpected influence of aryl substituents in N-aryl-3-oxobutanamides on the behavior of their multicomponent reactions with 5-amino-3-methylisoxazole and salicylaldehyde

  • Volodymyr V. Tkachenko,
  • Elena A. Muravyova,
  • Sergey M. Desenko,
  • Oleg V. Shishkin,
  • Svetlana V. Shishkina,
  • Dmytro O. Sysoiev,
  • Thomas J. J. Müller and
  • Valentin A. Chebanov

Beilstein J. Org. Chem. 2014, 10, 3019–3030, doi:10.3762/bjoc.10.320

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Published 17 Dec 2014

Synthesis of antibacterial 1,3-diyne-linked peptoids from an Ugi-4CR/Glaser coupling approach

  • Martin C. N. Brauer,
  • Ricardo A. W. Neves Filho,
  • Bernhard Westermann,
  • Ramona Heinke and
  • Ludger A. Wessjohann

Beilstein J. Org. Chem. 2015, 11, 25–30, doi:10.3762/bjoc.11.4

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Published 07 Jan 2015
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