Beilstein J. Org. Chem.2017,13, 1050–1063, doi:10.3762/bjoc.13.104
, Zhukovsky str., 66, 69600, Zaporizhzhya, Ukraine Faculty of Chemistry, V. N. Karazin Kharkiv National University, Svobody sq., 4, 61077, Kharkiv, Ukraine 10.3762/bjoc.13.104 Abstract The well-known aminoazoles, 3-amino-5-methylisoxazole and 5-amino-N-aryl-1H-pyrazole-4-carboxamides, were studied as an
obtained were evaluated for their antibacterial activity and several of them demonstrated a weak antimicrobial effect, but for most of the compounds a 30–50% increase in biomass of Gram-positive strains (mainly B. subtilis) compared to control was observed.
Keywords: 3-amino-5-methylisoxazole; 5-amino-N
aldehydes and alkylisocyanides giving the product resulting from GBB-3CR. On the other hand, 3-amino-5-methylisoxazole in MCRs often acted as primary amine [102][103][104][105][106], that was confirmed in our case by treatment with aromatic aldehydes, alkylisocyanides and phenylpropiolic acid resulting in