Beilstein J. Org. Chem.2016,12, 278–294, doi:10.3762/bjoc.12.30
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Preparation of SWCN CD-DOTA carrier.
Selected examples of conventional and non-conventional preparation of monosubstituted CDs.
Selected examples of conventional and MW-assisted preparation of monosubstituted CDs.
Beilstein J. Org. Chem.2015,11, 2202–2208, doi:10.3762/bjoc.11.239
” reaction, has been applied to the synthesis of a range of triazole-linked porphyrin/corrole to DOTA/NOTA derivatives. Microwave irradiation significantly accelerates the reaction. The synthesis of heterobimetallic complexes was easily achieved in up to 60% isolated yield. Heterobimetallic complexes were
are promising contrast agents (CA) in MRI.
Keywords: click chemistry; corrole; DOTA; microwave; NOTA; porphyrin; Introduction
Magnetic resonance imaging (MRI), positron emission tomography (PET) or single photon emission computed tomography (SPECT) are actually the most commonly used imaging
lead to a ‘marriage of convenience’ [1].
Our group previously reported the synthesis of porphyrin-DOTA-like scaffolds for multimodal imaging [2][3]. We were interested in heterobimetallic complexes incorporating both gadolinium and copper atoms. We now want to report new multimodal porphyrinoids-DOTA
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Graphical Abstract
Figure 1:
Selected ligands for the copper(I)-catalyzed Huisgen cycloaddition.