Beilstein J. Org. Chem.2013,9, 496–502, doi:10.3762/bjoc.9.53
Satyasheel Sharma Mahendra Nath Department of Chemistry, University of Delhi, Delhi 110 007, India 10.3762/bjoc.9.53 Abstract Novel dihydro-1,3-oxazinoporphyrins and naphtho[e]bis(dihydro-1,3-oxazinoporphyrin) derivatives, in which the porphyrin macrocycle is covalently linked to the dihydro-1,3
-oxazine ring system were successfully synthesized from 5-(4-aminophenyl)-10,15,20-triphenylporphyrin in good yields. The structures of the target products were established on the basis of spectral data and elemental analyses.
Keywords: dihydro-1,3-oxazinoporphyrins; iminoporphyrins; La(OTf)3; Mannich
anticancer significance of these two classes of molecules, it was contemplated to construct new dihydro-1,3-oxazinoporphyrins combining the porphyrin and dihydro-1,3-oxazine moieties in a single molecular framework. Such hybrid compounds may prove useful for pharmacological studies or in the development of
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Graphical Abstract
Scheme 1:
Synthesis of dihydro-1,3-benzoxazinoporphyrins.