A modular phosphate tether-mediated divergent strategy to complex polyols

• Paul R. Hanson,
• Susanthi Jayasinghe,
• Soma Maitra,
• Cornelius N. Ndi and
• Rambabu Chegondi

Beilstein J. Org. Chem. 2014, 10, 2332–2337, doi:10.3762/bjoc.10.242

• Paul R. Hanson Susanthi Jayasinghe Soma Maitra Cornelius N. Ndi Rambabu Chegondi Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USA 10.3762/bjoc.10.242 Abstract An efficient and divergent synthesis of polyol subunits utilizing a phosphate tether

• five polyol fragments. Each of the product polyols bears a central 1,3-anti-diol subunit with differential olefinic geometries at the periphery. Keywords: phosphate-tether; one-pot; sequential processes; organophosphorus; polyol; stereodivergent; Introduction 1,3-anti-Diol subunits are a central

• stereocenters, while invoking step- [17], atom- [18][19][20][21], green- [22][23], and pot economy [24][25][26]. We have previously reported phosphate tether-mediated strategies to streamline the synthesis of 1,3-anti-diol containing natural products, including recent reports employing one-pot, sequential