Direct electrophilic N-trifluoromethylthiolation of amines with trifluoromethanesulfenamide

• Sébastien Alazet,
• Kevin Ollivier and
• Thierry Billard

Beilstein J. Org. Chem. 2013, 9, 2354–2357, doi:10.3762/bjoc.9.270

• trifluoromethylsulfanylamines with good yields. Keywords: amine; fluorine; organo-fluorine; trifluoromethanesulfenamide; trifluoromethylsulfanylamine; trifluoromethylthiolation; Introduction In past decades, fluorinated molecules have found more and more applications in a variety of fields, especially in the design of new

• trifluoromethylsulfanylamine moiety (CF3SN). However, this group has found applications in agrochemical and medicinal chemistry [14][15][16][17][18][19][20]. From a physicochemical point of view, the CF3SN group possesses a Hansch’s hydrophobicity parameter πR = 1.50 [21]. This value, slightly superior to the Hansch’s