Beilstein J. Org. Chem.2017,13, 76–86, doi:10.3762/bjoc.13.10
Economics, 1521 Budapest, Hungary Department Chemie, Ludwig-Maximilians-Universität München, 81377 München, Germany Hungarian Academy of Sciences, Research Centre for Natural Sciences, Institute of Organic Chemistry, 1519 Budapest, Hungary 10.3762/bjoc.13.10 Abstract A family of α-aryl-α-aminophosphonates
was evaluated by DFT calculations. Two α-aminophosphonates were subjected to an X-ray study revealing a racemic dimer formation made through a N–H···O=P intermolecular hydrogen bridges pair.
Keywords: α-aryl-α-aminophosphine oxides; α-aryl-α-aminophosphonates; microwave; Pudovik reaction
which a >P(O)H species is added on the double bond of imines [11][12][13][14]. In this article, the latter pathway is utilized for the synthesis of α-aryl-α-aminophosphonates and α-aryl-α-aminophosphine oxides. In most cases, the additions were carried out in the presence of a catalyst and solvent. The
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Graphical Abstract
Scheme 1:
Synthesis of starting N-benzylideneamines 1.