Biosynthesis and function of secondary metabolites

  1. editorImage
  1. Editor: Dr. Jeroen S. Dickschat
    Technische Universität Braunschweig

The discovery of new bioactive natural products is still a fascinating field in organic chemistry as demonstrated by the recent paradigms of the anticancer drug epothilon, the immunosuppressant rapamycin, or the proteasome inhibitor salinosporamide,  to name but a few of hundreds of possible examples. Finding new secondary metabolites is a prerequisite for the development of novel pharmaceuticals, and this is an especially urgent task in the case of antibiotics due to the rapid spreading of bacterial resistances and the emergence of multiresistant pathogenic strains, which poses severe clinical problems in the treatment of infectious diseases. This Thematic Series on the biosynthesis and function of secondary metabolites deals with the discovery of new biologically active compounds from all kinds of sources, including plants, bacteria, and fungi, and also with their biogenesis. Biosynthetic aspects are closely related to functional investigations, because a deep understanding of metabolic pathways to natural products, not only on a chemical, but also on a genetic and enzymatic level, allows for the expression of whole biosynthetic gene clusters in heterologous hosts. This technique can make interesting, new secondary metabolites available from unculturable microorganisms, or may be used to optimise their availability by fermentation, for further research and also for production in the pharmaceutical industry.

See also the Thematic Series:
Natural products in synthesis and biosynthesis II
Natural products in synthesis and biosynthesis

  • Editorial
  • Published 05 Dec 2011

Beilstein J. Org. Chem. 2011, 7, 1620–1621, doi:10.3762/bjoc.7.190

Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes

  1. Jan-Christoph Kehr,
  2. Douglas Gatte Picchi and
  3. Elke Dittmann
  • Review
  • Published 05 Dec 2011

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Beilstein J. Org. Chem. 2011, 7, 1622–1635, doi:10.3762/bjoc.7.191

Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.

  1. Celso Almeida,
  2. Stefan Kehraus,
  3. Miguel Prudêncio and
  4. Gabriele M. König
  • Letter
  • Published 05 Dec 2011

Beilstein J. Org. Chem. 2011, 7, 1636–1642, doi:10.3762/bjoc.7.192

  • Letter
  • Published 05 Dec 2011

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  • Supp. Info

Beilstein J. Org. Chem. 2011, 7, 1643–1647, doi:10.3762/bjoc.7.193

Novel fatty acid methyl esters from the actinomycete Micromonospora aurantiaca

  1. Jeroen S. Dickschat,
  2. Hilke Bruns and
  3. Ramona Riclea
  • Full Research Paper
  • Published 20 Dec 2011

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  • Supp. Info

  • Video

Beilstein J. Org. Chem. 2011, 7, 1697–1712, doi:10.3762/bjoc.7.200

  • Full Research Paper
  • Published 21 Feb 2012

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Beilstein J. Org. Chem. 2012, 8, 283–289, doi:10.3762/bjoc.8.30

The volatiles of pathogenic and nonpathogenic mycobacteria and related bacteria

  1. Thorben Nawrath,
  2. Georgies F. Mgode,
  3. Bart Weetjens,
  4. Stefan H. E. Kaufmann and
  5. Stefan Schulz
  • Full Research Paper
  • Published 22 Feb 2012

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  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 290–299, doi:10.3762/bjoc.8.31

Mutational analysis of a phenazine biosynthetic gene cluster in Streptomyces anulatus 9663

  1. Orwah Saleh,
  2. Katrin Flinspach,
  3. Lucia Westrich,
  4. Andreas Kulik,
  5. Bertolt Gust,
  6. Hans-Peter Fiedler and
  7. Lutz Heide
  • Full Research Paper
  • Published 04 Apr 2012

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  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 501–513, doi:10.3762/bjoc.8.57

Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum

  1. Friederike I. Nollmann,
  2. Andrea Dowling,
  3. Marcel Kaiser,
  4. Klaus Deckmann,
  5. Sabine Grösch,
  6. Richard ffrench-Constant and
  7. Helge B. Bode
  • Letter
  • Published 11 Apr 2012

Beilstein J. Org. Chem. 2012, 8, 528–533, doi:10.3762/bjoc.8.60

Volatile organic compounds produced by the phytopathogenic bacterium Xanthomonas campestris pv. vesicatoria 85-10

  1. Teresa Weise,
  2. Marco Kai,
  3. Anja Gummesson,
  4. Armin Troeger,
  5. Stephan von Reuß,
  6. Silvia Piepenborn,
  7. Francine Kosterka,
  8. Martin Sklorz,
  9. Ralf Zimmermann,
  10. Wittko Francke and
  11. Birgit Piechulla
  • Full Research Paper
  • Published 17 Apr 2012

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Beilstein J. Org. Chem. 2012, 8, 579–596, doi:10.3762/bjoc.8.65

Phytoalexins of the Pyrinae: Biphenyls and dibenzofurans

  1. Cornelia Chizzali and
  2. Ludger Beerhues
  • Review
  • Published 20 Apr 2012

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Beilstein J. Org. Chem. 2012, 8, 613–620, doi:10.3762/bjoc.8.68

Identification and isolation of insecticidal oxazoles from Pseudomonas spp.

  1. Florian Grundmann,
  2. Veronika Dill,
  3. Andrea Dowling,
  4. Aunchalee Thanwisai,
  5. Edna Bode,
  6. Narisara Chantratita,
  7. Richard ffrench-Constant and
  8. Helge B. Bode
  • Letter
  • Published 18 May 2012

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  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 749–752, doi:10.3762/bjoc.8.85

Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations

  1. Tobias Knobloch,
  2. Gerald Dräger,
  3. Wera Collisi,
  4. Florenz Sasse and
  5. Andreas Kirschning
  • Full Research Paper
  • Published 11 Jun 2012

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  • Supp. Info

  • Video

Beilstein J. Org. Chem. 2012, 8, 861–869, doi:10.3762/bjoc.8.96

Algicidal lactones from the marine Roseobacter clade bacterium Ruegeria pomeroyi

  1. Ramona Riclea,
  2. Julia Gleitzmann,
  3. Hilke Bruns,
  4. Corina Junker,
  5. Barbara Schulz and
  6. Jeroen S. Dickschat
  • Full Research Paper
  • Published 25 Jun 2012

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  • Video

Beilstein J. Org. Chem. 2012, 8, 941–950, doi:10.3762/bjoc.8.106

  • Full Research Paper
  • Published 07 Aug 2012

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  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 1246–1255, doi:10.3762/bjoc.8.140

  • Full Research Paper
  • Published 08 Aug 2012

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  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 1256–1264, doi:10.3762/bjoc.8.141

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