Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

Scholarly Works

• Patel, A. K.; Samanta, S. Organocatalyzed Double C(sp3)−H Alkylation of Cyclic N‐Sulfonyl Ketimines with 3‐Chloropropiophenones: Selective Access to 2,3,6‐Trisubstituted Pyridines. European Journal of Organic Chemistry 2023, 26. doi:10.1002/ejoc.202300631
• Patel, A. K.; Rathor, S. S.; Samanta, S. Regioselective access to di- and trisubstituted pyridines via a metal-oxidant-solvent-free domino reaction involving 3-chloropropiophenones. Organic & biomolecular chemistry 2022, 20, 6759–6765. doi:10.1039/d2ob01193j
• Goud, S. B.; Guin, S.; Prakash, M.; Samanta, S. Cu(OAc)2/DABCO-mediated domino reaction of vinyl malononitriles with cyclic sulfamidate imines: access to 6-hydroxyaryl-2-aminonicotinonitriles. Organic & biomolecular chemistry 2022, 20, 352–357. doi:10.1039/d1ob02095a
• Sagandira, C. R.; Watts, P. Flow Chemistry Supporting Access to Drugs in Developing Countries. Topics in Medicinal Chemistry; Springer International Publishing, 2021; pp 391–419. doi:10.1007/7355_2021_114
• Sagandira, C. R.; Watts, P.
• de Souza, J. M.; Abdiaj, I.; Chen, J.; Hanson, K.; de Oliveira, K. T.; McQuade, D. T. Synthesis of multi-substituted pyridines from ylidenemalononitriles and their emission properties. Organic & biomolecular chemistry 2021, 19, 1991–1999. doi:10.1039/d0ob02591g
• Alizadeh, A.; Bagherinejad, A. Synthesis of 2‐O‐Functionalized‐5‐salicyloyl Pyridine Derivatives Catalyzed by 2‐Mercaptobenzimidazole. ChemistrySelect 2020, 5, 14303–14306. doi:10.1002/slct.202003748
• de Souza, J. M.; Abdiaj, I.; Chen, J.; Hanson, K.; de Oliveira, K. T.; McQuade, D. T. Increasing Scope of Clickable Fluorophores: Electrophilic Substitution of Ylidenemalononitriles. The Journal of organic chemistry 2020, 85, 11822–11834. doi:10.1021/acs.joc.0c01551
• Zhang, P.; Zheng, Z.; Yang, X.; Zhang, Y.; Hu, G.; Wang, R.; Dong, Y.; Wei, D. Discovery of novel 2-aminonicotinonitrile derivatives with new potential autophagy activity. Future medicinal chemistry 2020, 12, 1399–1414. doi:10.4155/fmc-2019-0244
• Prakash, M.; Gudimella, S. K.; Lodhi, R.; Guin, S.; Samanta, S. NH4OAc-Promoted Domino Route to Hydroxyarylated Unsymmetrical Pyridines under Neat Conditions. The Journal of organic chemistry 2020, 85, 2151–2167. doi:10.1021/acs.joc.9b02896
• Sim, J.; Viji, M.; Rhee, J.; Jo, H.; Cho, S. J.; Park, Y.; Seo, S.-Y.; Jung, K.-Y.; Lee, H.; Jung, J.-K. γ-Functionalization of α,β-Unsaturated Nitriles under Mild Conditions: Versatile Synthesis of 4-Aryl-2-Bromopyridines. Advanced Synthesis & Catalysis 2019, 361, 5458–5465. doi:10.1002/adsc.201901002
• Riley, D. L.; Strydom, I.; Chikwamba, R.; Panayides, J.-L. Landscape and opportunities for active pharmaceutical ingredient manufacturing in developing African economies. Reaction Chemistry & Engineering 2019, 4, 457–489. doi:10.1039/c8re00236c
• Diab, S.; McQuade, D. T.; Gupton, B. F.; Gerogiorgis, D. I. Process Design and Optimization for the Continuous Manufacturing of Nevirapine, an Active Pharmaceutical Ingredient for HIV Treatment. Organic Process Research & Development 2019, 23, 320–333. doi:10.1021/acs.oprd.8b00381
• Guin, S.; Gupta, R.; Majee, D.; Samanta, S. DABCO- and DBU-promoted one-pot reaction of N-sulfonyl ketimines with Morita-Baylis-Hillman carbonates: a sequential approach to (2-hydroxyaryl)nicotinate derivatives. Beilstein journal of organic chemistry 2018, 14, 2771–2778. doi:10.3762/bjoc.14.254
• Bardasov, I. N.; Alekseeva, A. Y.; Ershov, O. V. One-Pot Synthesis of 6-Alkyl-4-amino-2-bromopyridine-3,5-dicarbonitriles. Russian Journal of Organic Chemistry 2018, 54, 1106–1108. doi:10.1134/s1070428018070230
• Guin, S.; Majee, D.; Biswas, S.; Samanta, S. Microwave‐Assisted and Base‐Promoted Domino Reaction of Cyclic N‐Sulfonyl Ketimines with α,β‐Disubstituted Nitroalkenes: A Green Access to 2‐Hydroxyarylpyridines. Asian Journal of Organic Chemistry 2018, 7, 1810–1814. doi:10.1002/ajoc.201800298
• Gérardy, R.; Emmanuel, N.; Toupy, T.; Kassin, V.-E.; Tshibalonza, N. N.; Schmitz, M.; Monbaliu, J.-C. Continuous Flow Organic Chemistry: Successes and Pitfalls at the Interface with Current Societal Challenges. European Journal of Organic Chemistry 2018, 2018, 2301–2351. doi:10.1002/ejoc.201800149
• Gérardy, R.; Monbaliu, J.-C. Multistep Continuous-Flow Processes for the Preparation of Heterocyclic Active Pharmaceutical Ingredients. Topics in Heterocyclic Chemistry; Springer International Publishing, 2018; pp 1–102. doi:10.1007/7081_2018_21
• de Souza, R. O. M. A. Industrial Approaches Toward API Synthesis Under Continuous-Flow Conditions. Topics in Heterocyclic Chemistry; Springer International Publishing, 2018; pp 375–389. doi:10.1007/7081_2018_25
• Bardasov, I. N.; Alekseeva, A. U.; Ershov, O. V. Dibromomalononitrile-potassium bromide complex as a mild bromination and oxidation reagent for the synthesis of mono-, di- and trimethoxyphenyl bromopyridines. Tetrahedron Letters 2018, 59, 1398–1399. doi:10.1016/j.tetlet.2018.02.069

Explore citations to this article at