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Beilstein Organic Chemistry Symposium 2014

Chemistry in flow systems II


Editor: Prof. Andreas Kirschning
Leibniz Universität Hannover


This is the second Thematic Series on chemistry in flow systems. Flow chemistry is an enabling technology that was introduced to the laboratories of synthetic organic chemists around ten years ago and has flourished now for about half a decade. This series contains representative examples of fields in organic synthesis where continuous flow conditions have already made a significant impact. First of all, there is the application to photochemistry, which has the chance of experiencing a renaissance particularly in an industrial environment. Second, flow chemistry lends itself naturally to the synthesis and direct application of reactive intermediates or reactive reagents, which are difficult to handle in a batch reactor. And third, new heating concepts, including inductive heating, are rendered possible, allowing accelerated synthesis under pressure, up to supercritical conditions, but whereby only a small volume of the reaction mixture inside the flow reactor is exposed to these extreme conditions.

 
Overview

Chemistry in flow systems II

Andreas Kirschning

Beilstein J. Org. Chem. 2011, 7, 1046–1047. published 02 Aug 2011

Editorial

Unusual behavior in the reactivity of 5-substituted-1H-tetrazoles in a resistively heated microreactor

Bernhard Gutmann, Toma N. Glasnov, Tahseen Razzaq, Walter Goessler, Dominique M. Roberge, C. Oliver Kappe

Beilstein J. Org. Chem. 2011, 7, 503–517. published 21 Apr 2011

Full Research Paper

Continuous flow hydrogenation using polysilane-supported palladium/alumina hybrid catalysts

Hidekazu Oyamada, Takeshi Naito, Shū Kobayashi

Beilstein J. Org. Chem. 2011, 7, 735–739. published 31 May 2011

Letter

Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination

Jessica R. Breen, Graham Sandford, Dmitrii S. Yufit, Judith A. K. Howard, Jonathan Fray, Bhairavi Patel

Beilstein J. Org. Chem. 2011, 7, 1048–1054. published 02 Aug 2011

Full Research Paper

Microphotochemistry: 4,4'-Dimethoxybenzophenone mediated photodecarboxylation reactions involving phthalimides

Oksana Shvydkiv, Kieran Nolan, Michael Oelgemöller

Beilstein J. Org. Chem. 2011, 7, 1055–1063. published 02 Aug 2011

Full Research Paper

Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocoupling

Aiichiro Nagaki, Yuki Uesugi, Yutaka Tomida, Jun-ichi Yoshida

Beilstein J. Org. Chem. 2011, 7, 1064–1069. published 02 Aug 2011

Full Research Paper

A practical microreactor for electrochemistry in flow

Kevin Watts, William Gattrell, Thomas Wirth

Beilstein J. Org. Chem. 2011, 7, 1108–1114. published 15 Aug 2011

Full Research Paper

Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones

Farhan R. Bou-Hamdan, François Lévesque, Alexander G. O'Brien, Peter H. Seeberger

Beilstein J. Org. Chem. 2011, 7, 1124–1129. published 17 Aug 2011

Letter

Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis

Marian C. Bryan, David Wernick, Christopher D. Hein, James V. Petersen, John W. Eschelbach, Elizabeth M. Doherty

Beilstein J. Org. Chem. 2011, 7, 1141–1149. published 22 Aug 2011

Full Research Paper

Scaling up of continuous-flow, microwave-assisted, organic reactions by varying the size of Pd-functionalized catalytic monoliths

Ping He, Stephen J. Haswell, Paul D. I. Fletcher, Stephen M. Kelly, Andrew Mansfield

Beilstein J. Org. Chem. 2011, 7, 1150–1157. published 23 Aug 2011

Full Research Paper

Triple-channel microreactor for biphasic gas–liquid reactions: Photosensitized oxygenations

Ram Awatar Maurya, Chan Pil Park, Dong-Pyo Kim

Beilstein J. Org. Chem. 2011, 7, 1158–1163. published 24 Aug 2011

Letter

The Eschenmoser coupling reaction under continuous-flow conditions

Sukhdeep Singh, J. Michael Köhler, Andreas Schober, G. Alexander Groß

Beilstein J. Org. Chem. 2011, 7, 1164–1172. published 25 Aug 2011

Full Research Paper

Koch–Haaf reaction of adamantanols in an acid-tolerant hastelloy-made microreactor

Takahide Fukuyama, Yu Mukai, Ilhyong Ryu

Beilstein J. Org. Chem. 2011, 7, 1288–1293. published 15 Sep 2011

Letter

Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluids

M. Isabel Burguete, Eduardo García-Verdugo, Santiago V. Luis

Beilstein J. Org. Chem. 2011, 7, 1347–1359. published 30 Sep 2011

Review

Translation of microwave methodology to continuous flow for the efficient synthesis of diaryl ethers via a base-mediated SNAr reaction

Charlotte Wiles, Paul Watts

Beilstein J. Org. Chem. 2011, 7, 1360–1371. published 04 Oct 2011

Full Research Paper

Continuous preparation of carbon-nanotube-supported platinum catalysts in a flow reactor directly heated by electric current

Alicja Schlange, Antonio Rodolfo dos Santos, Ulrich Kunz, Thomas Turek

Beilstein J. Org. Chem. 2011, 7, 1412–1420. published 14 Oct 2011

Full Research Paper

Multistep flow synthesis of vinyl azides and their use in the copper-catalyzed Huisgen-type cycloaddition under inductive-heating conditions

Lukas Kupracz, Jan Hartwig, Jens Wegner, Sascha Ceylan, Andreas Kirschning

Beilstein J. Org. Chem. 2011, 7, 1441–1448. published 20 Oct 2011

Full Research Paper

Coupled chemo(enzymatic) reactions in continuous flow

Ruslan Yuryev, Simon Strompen, Andreas Liese

Beilstein J. Org. Chem. 2011, 7, 1449–1467. published 24 Oct 2011

Review

Continuous-flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyproline

Xacobe C. Cambeiro, Rafael Martín-Rapún, Pedro O. Miranda, Sonia Sayalero, Esther Alza, Patricia Llanes, Miquel A. Pericàs

Beilstein J. Org. Chem. 2011, 7, 1486–1493. published 31 Oct 2011

Full Research Paper

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Kimberley A. Roper, Heiko Lange, Anastasios Polyzos, Malcolm B. Berry, Ian R. Baxendale, Steven V. Ley

Beilstein J. Org. Chem. 2011, 7, 1648–1655. published 08 Dec 2011

Full Research Paper

Continuous proline catalysis via leaching of solid proline

Suzanne M. Opalka, Ashley R. Longstreet, D. Tyler McQuade

Beilstein J. Org. Chem. 2011, 7, 1671–1679. published 14 Dec 2011

Full Research Paper

Continuous-flow hydration–condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst

Magnus Rueping, Teerawut Bootwicha, Hannah Baars, Erli Sugiono

Beilstein J. Org. Chem. 2011, 7, 1680–1687. published 15 Dec 2011

Full Research Paper

Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis

Magnus Rueping, Teerawut Bootwicha, Erli Sugiono

Beilstein J. Org. Chem. 2012, 8, 300–307. published 23 Feb 2012

Full Research Paper