Chemistry in flow systems II

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Editor: Prof. Andreas Kirschning
Leibniz Universität Hannover
 
This is the second Thematic Series on chemistry in flow systems. Flow chemistry is an enabling technology that was introduced to the laboratories of synthetic organic chemists around ten years ago and has flourished now for about half a decade. This series contains representative examples of fields in organic synthesis where continuous flow conditions have already made a significant impact. First of all, there is the application to photochemistry, which has the chance of experiencing a renaissance particularly in an industrial environment. Second, flow chemistry lends itself naturally to the synthesis and direct application of reactive intermediates or reactive reagents, which are difficult to handle in a batch reactor. And third, new heating concepts, including inductive heating, are rendered possible, allowing accelerated synthesis under pressure, up to supercritical conditions, but whereby only a small volume of the reaction mixture inside the flow reactor is exposed to these extreme conditions.

See also the Thematic Series:
Chemistry in flow systems III
Chemistry in flow systems

See videos about flow chemistry at Beilstein TV.

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Chemistry in flow systems II

  • Andreas Kirschning

Beilstein J. Org. Chem. 2011, 7, 1046–1047, doi:10.3762/bjoc.7.119

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Published 02 Aug 2011

Unusual behavior in the reactivity of 5-substituted-1H-tetrazoles in a resistively heated microreactor

  • Bernhard Gutmann,
  • Toma N. Glasnov,
  • Tahseen Razzaq,
  • Walter Goessler,
  • Dominique M. Roberge and
  • C. Oliver Kappe

Beilstein J. Org. Chem. 2011, 7, 503–517, doi:10.3762/bjoc.7.59

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Published 21 Apr 2011

Continuous flow hydrogenation using polysilane-supported palladium/alumina hybrid catalysts

  • Hidekazu Oyamada,
  • Takeshi Naito and
  • Shū Kobayashi

Beilstein J. Org. Chem. 2011, 7, 735–739, doi:10.3762/bjoc.7.83

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Published 31 May 2011

Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination

  • Jessica R. Breen,
  • Graham Sandford,
  • Dmitrii S. Yufit,
  • Judith A. K. Howard,
  • Jonathan Fray and
  • Bhairavi Patel

Beilstein J. Org. Chem. 2011, 7, 1048–1054, doi:10.3762/bjoc.7.120

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Published 02 Aug 2011

Microphotochemistry: 4,4'-Dimethoxybenzophenone mediated photodecarboxylation reactions involving phthalimides

  • Oksana Shvydkiv,
  • Kieran Nolan and
  • Michael Oelgemöller

Beilstein J. Org. Chem. 2011, 7, 1055–1063, doi:10.3762/bjoc.7.121

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Published 02 Aug 2011

Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocoupling

  • Aiichiro Nagaki,
  • Yuki Uesugi,
  • Yutaka Tomida and
  • Jun-ichi Yoshida

Beilstein J. Org. Chem. 2011, 7, 1064–1069, doi:10.3762/bjoc.7.122

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Published 02 Aug 2011

A practical microreactor for electrochemistry in flow

  • Kevin Watts,
  • William Gattrell and
  • Thomas Wirth

Beilstein J. Org. Chem. 2011, 7, 1108–1114, doi:10.3762/bjoc.7.127

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Published 15 Aug 2011

Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones

  • Farhan R. Bou-Hamdan,
  • François Lévesque,
  • Alexander G. O'Brien and
  • Peter H. Seeberger

Beilstein J. Org. Chem. 2011, 7, 1124–1129, doi:10.3762/bjoc.7.129

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Published 17 Aug 2011

Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis

  • Marian C. Bryan,
  • David Wernick,
  • Christopher D. Hein,
  • James V. Petersen,
  • John W. Eschelbach and
  • Elizabeth M. Doherty

Beilstein J. Org. Chem. 2011, 7, 1141–1149, doi:10.3762/bjoc.7.132

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Published 22 Aug 2011

Scaling up of continuous-flow, microwave-assisted, organic reactions by varying the size of Pd-functionalized catalytic monoliths

  • Ping He,
  • Stephen J. Haswell,
  • Paul D. I. Fletcher,
  • Stephen M. Kelly and
  • Andrew Mansfield

Beilstein J. Org. Chem. 2011, 7, 1150–1157, doi:10.3762/bjoc.7.133

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Published 23 Aug 2011

Triple-channel microreactor for biphasic gas–liquid reactions: Photosensitized oxygenations

  • Ram Awatar Maurya,
  • Chan Pil Park and
  • Dong-Pyo Kim

Beilstein J. Org. Chem. 2011, 7, 1158–1163, doi:10.3762/bjoc.7.134

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Published 24 Aug 2011

The Eschenmoser coupling reaction under continuous-flow conditions

  • Sukhdeep Singh,
  • J. Michael Köhler,
  • Andreas Schober and
  • G. Alexander Groß

Beilstein J. Org. Chem. 2011, 7, 1164–1172, doi:10.3762/bjoc.7.135

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Published 25 Aug 2011

Koch–Haaf reaction of adamantanols in an acid-tolerant hastelloy-made microreactor

  • Takahide Fukuyama,
  • Yu Mukai and
  • Ilhyong Ryu

Beilstein J. Org. Chem. 2011, 7, 1288–1293, doi:10.3762/bjoc.7.149

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Published 15 Sep 2011

Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluids

  • M. Isabel Burguete,
  • Eduardo García-Verdugo and
  • Santiago V. Luis

Beilstein J. Org. Chem. 2011, 7, 1347–1359, doi:10.3762/bjoc.7.159

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Published 30 Sep 2011

Translation of microwave methodology to continuous flow for the efficient synthesis of diaryl ethers via a base-mediated SNAr reaction

  • Charlotte Wiles and
  • Paul Watts

Beilstein J. Org. Chem. 2011, 7, 1360–1371, doi:10.3762/bjoc.7.160

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Published 04 Oct 2011

Continuous preparation of carbon-nanotube-supported platinum catalysts in a flow reactor directly heated by electric current

  • Alicja Schlange,
  • Antonio Rodolfo dos Santos,
  • Ulrich Kunz and
  • Thomas Turek

Beilstein J. Org. Chem. 2011, 7, 1412–1420, doi:10.3762/bjoc.7.165

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Published 14 Oct 2011

Multistep flow synthesis of vinyl azides and their use in the copper-catalyzed Huisgen-type cycloaddition under inductive-heating conditions

  • Lukas Kupracz,
  • Jan Hartwig,
  • Jens Wegner,
  • Sascha Ceylan and
  • Andreas Kirschning

Beilstein J. Org. Chem. 2011, 7, 1441–1448, doi:10.3762/bjoc.7.168

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Published 20 Oct 2011

Coupled chemo(enzymatic) reactions in continuous flow

  • Ruslan Yuryev,
  • Simon Strompen and
  • Andreas Liese

Beilstein J. Org. Chem. 2011, 7, 1449–1467, doi:10.3762/bjoc.7.169

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Published 24 Oct 2011

Continuous-flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyproline

  • Xacobe C. Cambeiro,
  • Rafael Martín-Rapún,
  • Pedro O. Miranda,
  • Sonia Sayalero,
  • Esther Alza,
  • Patricia Llanes and
  • Miquel A. Pericàs

Beilstein J. Org. Chem. 2011, 7, 1486–1493, doi:10.3762/bjoc.7.172

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Published 31 Oct 2011

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

  • Kimberley A. Roper,
  • Heiko Lange,
  • Anastasios Polyzos,
  • Malcolm B. Berry,
  • Ian R. Baxendale and
  • Steven V. Ley

Beilstein J. Org. Chem. 2011, 7, 1648–1655, doi:10.3762/bjoc.7.194

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Published 08 Dec 2011

Continuous proline catalysis via leaching of solid proline

  • Suzanne M. Opalka,
  • Ashley R. Longstreet and
  • D. Tyler McQuade

Beilstein J. Org. Chem. 2011, 7, 1671–1679, doi:10.3762/bjoc.7.197

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Published 14 Dec 2011

Continuous-flow hydration–condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst

  • Magnus Rueping,
  • Teerawut Bootwicha,
  • Hannah Baars and
  • Erli Sugiono

Beilstein J. Org. Chem. 2011, 7, 1680–1687, doi:10.3762/bjoc.7.198

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Published 15 Dec 2011

Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis

  • Magnus Rueping,
  • Teerawut Bootwicha and
  • Erli Sugiono

Beilstein J. Org. Chem. 2012, 8, 300–307, doi:10.3762/bjoc.8.32

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Published 23 Feb 2012
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