Chemistry in flow systems II
Editor: Prof. Andreas Kirschning
Leibniz Universität Hannover
This is the second Thematic Series on chemistry in flow systems. Flow chemistry is an enabling technology that was introduced to the laboratories of synthetic organic chemists around ten years ago and has flourished now for about half a decade. This series contains representative examples of fields in organic synthesis where continuous flow conditions have already made a significant impact. First of all, there is the application to photochemistry, which has the chance of experiencing a renaissance particularly in an industrial environment. Second, flow chemistry lends itself naturally to the synthesis and direct application of reactive intermediates or reactive reagents, which are difficult to handle in a batch reactor. And third, new heating concepts, including inductive heating, are rendered possible, allowing accelerated synthesis under pressure, up to supercritical conditions, but whereby only a small volume of the reaction mixture inside the flow reactor is exposed to these extreme conditions.
Chemistry in flow systems IIAndreas Kirschning Beilstein J. Org. Chem. 2011, 7, 1046–1047. published 02 Aug 2011 Editorial
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Unusual behavior in the reactivity of 5-substituted-1H-tetrazoles in a resistively heated microreactorBernhard Gutmann, Toma N. Glasnov, Tahseen Razzaq, Walter Goessler, Dominique M. Roberge, C. Oliver Kappe Beilstein J. Org. Chem. 2011, 7, 503–517. published 21 Apr 2011 Full Research Paper
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Continuous flow hydrogenation using polysilane-supported palladium/alumina hybrid catalystsHidekazu Oyamada, Takeshi Naito, Shū Kobayashi Beilstein J. Org. Chem. 2011, 7, 735–739. published 31 May 2011 Letter
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Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorinationJessica R. Breen, Graham Sandford, Dmitrii S. Yufit, Judith A. K. Howard, Jonathan Fray, Bhairavi Patel Beilstein J. Org. Chem. 2011, 7, 1048–1054. published 02 Aug 2011 Full Research Paper
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Microphotochemistry: 4,4'-Dimethoxybenzophenone mediated photodecarboxylation reactions involving phthalimidesOksana Shvydkiv, Kieran Nolan, Michael Oelgemöller Beilstein J. Org. Chem. 2011, 7, 1055–1063. published 02 Aug 2011 Full Research Paper
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Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocouplingAiichiro Nagaki, Yuki Uesugi, Yutaka Tomida, Jun-ichi Yoshida Beilstein J. Org. Chem. 2011, 7, 1064–1069. published 02 Aug 2011 Full Research Paper
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A practical microreactor for electrochemistry in flowKevin Watts, William Gattrell, Thomas Wirth Beilstein J. Org. Chem. 2011, 7, 1108–1114. published 15 Aug 2011 Full Research Paper
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Continuous flow photolysis of aryl azides: Preparation of 3H-azepinonesFarhan R. Bou-Hamdan, François Lévesque, Alexander G. O'Brien, Peter H. Seeberger Beilstein J. Org. Chem. 2011, 7, 1124–1129. published 17 Aug 2011 Letter
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Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesisMarian C. Bryan, David Wernick, Christopher D. Hein, James V. Petersen, John W. Eschelbach, Elizabeth M. Doherty Beilstein J. Org. Chem. 2011, 7, 1141–1149. published 22 Aug 2011 Full Research Paper
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Scaling up of continuous-flow, microwave-assisted, organic reactions by varying the size of Pd-functionalized catalytic monolithsPing He, Stephen J. Haswell, Paul D. I. Fletcher, Stephen M. Kelly, Andrew Mansfield Beilstein J. Org. Chem. 2011, 7, 1150–1157. published 23 Aug 2011 Full Research Paper
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Triple-channel microreactor for biphasic gas–liquid reactions: Photosensitized oxygenationsRam Awatar Maurya, Chan Pil Park, Dong-Pyo Kim Beilstein J. Org. Chem. 2011, 7, 1158–1163. published 24 Aug 2011 Letter
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The Eschenmoser coupling reaction under continuous-flow conditionsSukhdeep Singh, J. Michael Köhler, Andreas Schober, G. Alexander Groß Beilstein J. Org. Chem. 2011, 7, 1164–1172. published 25 Aug 2011 Full Research Paper
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Koch–Haaf reaction of adamantanols in an acid-tolerant hastelloy-made microreactorTakahide Fukuyama, Yu Mukai, Ilhyong Ryu Beilstein J. Org. Chem. 2011, 7, 1288–1293. published 15 Sep 2011 Letter
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Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluidsM. Isabel Burguete, Eduardo García-Verdugo, Santiago V. Luis Beilstein J. Org. Chem. 2011, 7, 1347–1359. published 30 Sep 2011 Review
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Translation of microwave methodology to continuous flow for the efficient synthesis of diaryl ethers via a base-mediated SNAr reactionCharlotte Wiles, Paul Watts Beilstein J. Org. Chem. 2011, 7, 1360–1371. published 04 Oct 2011 Full Research Paper
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Continuous preparation of carbon-nanotube-supported platinum catalysts in a flow reactor directly heated by electric currentAlicja Schlange, Antonio Rodolfo dos Santos, Ulrich Kunz, Thomas Turek Beilstein J. Org. Chem. 2011, 7, 1412–1420. published 14 Oct 2011 Full Research Paper
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Multistep flow synthesis of vinyl azides and their use in the copper-catalyzed Huisgen-type cycloaddition under inductive-heating conditionsLukas Kupracz, Jan Hartwig, Jens Wegner, Sascha Ceylan, Andreas Kirschning Beilstein J. Org. Chem. 2011, 7, 1441–1448. published 20 Oct 2011 Full Research Paper
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Coupled chemo(enzymatic) reactions in continuous flowRuslan Yuryev, Simon Strompen, Andreas Liese Beilstein J. Org. Chem. 2011, 7, 1449–1467. published 24 Oct 2011 Review
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Continuous-flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyprolineXacobe C. Cambeiro, Rafael Martín-Rapún, Pedro O. Miranda, Sonia Sayalero, Esther Alza, Patricia Llanes, Miquel A. Pericàs Beilstein J. Org. Chem. 2011, 7, 1486–1493. published 31 Oct 2011 Full Research Paper
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The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactorsKimberley A. Roper, Heiko Lange, Anastasios Polyzos, Malcolm B. Berry, Ian R. Baxendale, Steven V. Ley Beilstein J. Org. Chem. 2011, 7, 1648–1655. published 08 Dec 2011 Full Research Paper
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Continuous proline catalysis via leaching of solid prolineSuzanne M. Opalka, Ashley R. Longstreet, D. Tyler McQuade Beilstein J. Org. Chem. 2011, 7, 1671–1679. published 14 Dec 2011 Full Research Paper
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Continuous-flow hydration–condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalystMagnus Rueping, Teerawut Bootwicha, Hannah Baars, Erli Sugiono Beilstein J. Org. Chem. 2011, 7, 1680–1687. published 15 Dec 2011 Full Research Paper
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Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysisMagnus Rueping, Teerawut Bootwicha, Erli Sugiono Beilstein J. Org. Chem. 2012, 8, 300–307. published 23 Feb 2012 Full Research Paper
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