Chemistry in flow systems III

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Editor: Prof. Andreas Kirschning
Leibniz Universität Hannover
 
The third Thematic Series on flow chemistry demonstrates the emerging importance of transforming chemical synthesis in the laboratory from a classical batch approach to continuous processes by using micro- and miniaturized flow reactors. In the past two decades this technology has seen a dramatic increase of visibility. Considering an analyses of the accompanied developments in flow synthesis one has to acknowledge that the topic has shifted among different disciplines with a variety of intensities and focus. In the late eighties and nineties, the idea of miniaturising continuous chemical processes was mainly pursued by chemical engineers. In the late nineties, organic chemists from both industry and academia became involved in the use of microreactors and provided a myriad of synthetic examples.

See also the Thematic Series:
Chemistry in flow systems II
Chemistry in flow systems

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Chemistry in flow systems III

  • Andreas Kirschning

Beilstein J. Org. Chem. 2013, 9, 1696–1697, doi:10.3762/bjoc.9.193

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Published 16 Aug 2013

3D-printed devices for continuous-flow organic chemistry

  • Vincenza Dragone,
  • Victor Sans,
  • Mali H. Rosnes,
  • Philip J. Kitson and
  • Leroy Cronin

Beilstein J. Org. Chem. 2013, 9, 951–959, doi:10.3762/bjoc.9.109

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Published 16 May 2013

Simple and rapid hydrogenation of p-nitrophenol with aqueous formic acid in catalytic flow reactors

  • Rahat Javaid,
  • Shin-ichiro Kawasaki,
  • Akira Suzuki and
  • Toshishige M. Suzuki

Beilstein J. Org. Chem. 2013, 9, 1156–1163, doi:10.3762/bjoc.9.129

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Published 14 Jun 2013

Hypervalent iodine/TEMPO-mediated oxidation in flow systems: a fast and efficient protocol for alcohol oxidation

  • Nida Ambreen,
  • Ravi Kumar and
  • Thomas Wirth

Beilstein J. Org. Chem. 2013, 9, 1437–1442, doi:10.3762/bjoc.9.162

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Published 17 Jul 2013

Controlled synthesis of poly(3-hexylthiophene) in continuous flow

  • Helga Seyler,
  • Jegadesan Subbiah,
  • David J. Jones,
  • Andrew B. Holmes and
  • Wallace W. H. Wong

Beilstein J. Org. Chem. 2013, 9, 1492–1500, doi:10.3762/bjoc.9.170

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Published 25 Jul 2013

Efficient continuous-flow synthesis of novel 1,2,3-triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production

  • Sándor B. Ötvös,
  • Ádám Georgiádes,
  • István M. Mándity,
  • Lóránd Kiss and
  • Ferenc Fülöp

Beilstein J. Org. Chem. 2013, 9, 1508–1516, doi:10.3762/bjoc.9.172

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Published 29 Jul 2013

The rapid generation of isothiocyanates in flow

  • Marcus Baumann and
  • Ian R. Baxendale

Beilstein J. Org. Chem. 2013, 9, 1613–1619, doi:10.3762/bjoc.9.184

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Published 08 Aug 2013

Gallium-containing polymer brush film as efficient supported Lewis acid catalyst in a glass microreactor

  • Rajesh Munirathinam,
  • Roberto Ricciardi,
  • Richard J. M. Egberink,
  • Jurriaan Huskens,
  • Michael Holtkamp,
  • Herbert Wormeester,
  • Uwe Karst and
  • Willem Verboom

Beilstein J. Org. Chem. 2013, 9, 1698–1704, doi:10.3762/bjoc.9.194

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Published 16 Aug 2013

[3 + 2]-Cycloadditions of nitrile ylides after photoactivation of vinyl azides under flow conditions

  • Stephan Cludius-Brandt,
  • Lukas Kupracz and
  • Andreas Kirschning

Beilstein J. Org. Chem. 2013, 9, 1745–1750, doi:10.3762/bjoc.9.201

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Published 26 Aug 2013

The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow

  • Kimberley A. Roper,
  • Malcolm B. Berry and
  • Steven V. Ley

Beilstein J. Org. Chem. 2013, 9, 1781–1790, doi:10.3762/bjoc.9.207

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Published 02 Sep 2013

Flow Giese reaction using cyanoborohydride as a radical mediator

  • Takahide Fukuyama,
  • Takuji Kawamoto,
  • Mikako Kobayashi and
  • Ilhyong Ryu

Beilstein J. Org. Chem. 2013, 9, 1791–1796, doi:10.3762/bjoc.9.208

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Published 03 Sep 2013

Ethyl diazoacetate synthesis in flow

  • Mariëlle M. E. Delville,
  • Jan C. M. van Hest and
  • Floris P. J. T. Rutjes

Beilstein J. Org. Chem. 2013, 9, 1813–1818, doi:10.3762/bjoc.9.211

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Published 05 Sep 2013

Integrating reaction and analysis: investigation of higher-order reactions by cryogenic trapping

  • Skrollan Stockinger and
  • Oliver Trapp

Beilstein J. Org. Chem. 2013, 9, 1837–1842, doi:10.3762/bjoc.9.214

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Published 10 Sep 2013

Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions

  • Trevor A. Hamlin and
  • Nicholas E. Leadbeater

Beilstein J. Org. Chem. 2013, 9, 1843–1852, doi:10.3762/bjoc.9.215

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Published 11 Sep 2013

Continuous flow photocyclization of stilbenes – scalable synthesis of functionalized phenanthrenes and helicenes

  • Quentin Lefebvre,
  • Marc Jentsch and
  • Magnus Rueping

Beilstein J. Org. Chem. 2013, 9, 1883–1890, doi:10.3762/bjoc.9.221

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Published 17 Sep 2013

One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor

  • Mark C. Bagley,
  • Vincenzo Fusillo,
  • Robert L. Jenkins,
  • M. Caterina Lubinu and
  • Christopher Mason

Beilstein J. Org. Chem. 2013, 9, 1957–1968, doi:10.3762/bjoc.9.232

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Published 30 Sep 2013

Microflow photochemistry: UVC-induced [2 + 2]-photoadditions to furanone in a microcapillary reactor

  • Sylvestre Bachollet,
  • Kimitada Terao,
  • Shin Aida,
  • Yasuhiro Nishiyama,
  • Kiyomi Kakiuchi and
  • Michael Oelgemöller

Beilstein J. Org. Chem. 2013, 9, 2015–2021, doi:10.3762/bjoc.9.237

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Published 04 Oct 2013

Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe

  • Matthew B. Plutschack,
  • D. Tyler McQuade,
  • Giulio Valenti and
  • Peter H. Seeberger

Beilstein J. Org. Chem. 2013, 9, 2022–2027, doi:10.3762/bjoc.9.238

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Published 07 Oct 2013

Temperature measurements with two different IR sensors in a continuous-flow microwave heated system

  • Jonas Rydfjord,
  • Fredrik Svensson,
  • Magnus Fagrell,
  • Jonas Sävmarker,
  • Måns Thulin and
  • Mats Larhed

Beilstein J. Org. Chem. 2013, 9, 2079–2087, doi:10.3762/bjoc.9.244

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Published 10 Oct 2013

Flow synthesis of phenylserine using threonine aldolase immobilized on Eupergit support

  • Jagdish D. Tibhe,
  • Hui Fu,
  • Timothy Noël,
  • Qi Wang,
  • Jan Meuldijk and
  • Volker Hessel

Beilstein J. Org. Chem. 2013, 9, 2168–2179, doi:10.3762/bjoc.9.254

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Published 22 Oct 2013

Micro-flow synthesis and structural analysis of sterically crowded diimine ligands with five aryl rings

  • Shinichiro Fuse,
  • Nobutake Tanabe,
  • Akio Tannna,
  • Yohei Konishi and
  • Takashi Takahashi

Beilstein J. Org. Chem. 2013, 9, 2336–2343, doi:10.3762/bjoc.9.268

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Published 01 Nov 2013

Synthesis of homo- and heteromultivalent carbohydrate-functionalized oligo(amidoamines) using novel glyco-building blocks

  • Felix Wojcik,
  • Sinaida Lel,
  • Alexander G. O’Brien,
  • Peter H. Seeberger and
  • Laura Hartmann

Beilstein J. Org. Chem. 2013, 9, 2395–2403, doi:10.3762/bjoc.9.276

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Published 07 Nov 2013

A combined continuous microflow photochemistry and asymmetric organocatalysis approach for the enantioselective synthesis of tetrahydroquinolines

  • Erli Sugiono and
  • Magnus Rueping

Beilstein J. Org. Chem. 2013, 9, 2457–2462, doi:10.3762/bjoc.9.284

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Published 13 Nov 2013

Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

  • Ashley R. Longstreet,
  • Suzanne M. Opalka,
  • Brian S. Campbell,
  • B. Frank Gupton and
  • D. Tyler McQuade

Beilstein J. Org. Chem. 2013, 9, 2570–2578, doi:10.3762/bjoc.9.292

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Published 20 Nov 2013

Continuous-flow Heck synthesis of 4-methoxybiphenyl and methyl 4-methoxycinnamate in supercritical carbon dioxide expanded solvent solutions

  • Phei Li Lau,
  • Ray W. K. Allen and
  • Peter Styring

Beilstein J. Org. Chem. 2013, 9, 2886–2897, doi:10.3762/bjoc.9.325

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Published 17 Dec 2013

Continuous flow nitration in miniaturized devices

  • Amol A. Kulkarni

Beilstein J. Org. Chem. 2014, 10, 405–424, doi:10.3762/bjoc.10.38

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Published 14 Feb 2014
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