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Chemistry in flow systems


Editor: Prof. Andreas Kirschning
Leibniz Universität Hannover

The automation of chemical synthesis with the resulting savings in time and materials and reduction in the use of environmentally harmful chemicals has been the goal of many academic and industrial chemists for a long time. Over recent years the application of flow devices in laboratories has been gaining acceptance with increased sophistication in their control and ease of use. The advantages that flow devices bring are many, for example: easier scale up, better and precise control of reaction conditions, better mixing, easier handling of unstable intermediates, in-system purification. An important field of research is the optimization and adaptation of known reactions and reaction sequences for use in flow systems. Continuous-flow processes can be further improved by techniques that use immobilized reagents or catalysts, or by using fixed bed reactors in parallel. These developments in flow techniques using mini and micro flow reactors have initiated changes that will pave the way for a technological step forward in chemical synthesis.



 
Overview

Chemistry in flow systems

Andreas Kirschning

Beilstein J. Org. Chem. 2009, 5, No. 15. published 29 Apr 2009

Editorial

Synthesis of unsymmetrically substituted biaryls via sequential lithiation of dibromobiaryls using integrated microflow systems

Aiichiro Nagaki, Naofumi Takabayashi, Yutaka Tomida, Jun-ichi Yoshida

Beilstein J. Org. Chem. 2009, 5, No. 16. published 29 Apr 2009

Full Research Paper

A biphasic oxidation of alcohols to aldehydes and ketones using a simplified packed- bed microreactor

Andrew Bogdan, D. Tyler McQuade

Beilstein J. Org. Chem. 2009, 5, No. 17. published 29 Apr 2009

Full Research Paper

Oxidative cyclization of alkenols with Oxone using a miniflow reactor

Yoichi M. A. Yamada, Kaoru Torii, Yasuhiro Uozumi

Beilstein J. Org. Chem. 2009, 5, No. 18. published 29 Apr 2009

Preliminary Communication

Asymmetric reactions in continuous flow

Xiao Yin Mak, Paola Laurino, Peter H. Seeberger

Beilstein J. Org. Chem. 2009, 5, No. 19. published 29 Apr 2009

Review

Polyionic polymers – heterogeneous media for metal nanoparticles as catalyst in Suzuki–Miyaura and Heck–Mizoroki reactions under flow conditions

Klaas Mennecke, Andreas Kirschning

Beilstein J. Org. Chem. 2009, 5, No. 21. published 08 May 2009

Full Research Paper

Continuous flow based catch and release protocol for the synthesis of α-ketoesters

Alessandro Palmieri, Steven V. Ley, Anastasios Polyzos, Mark Ladlow, Ian R. Baxendale

Beilstein J. Org. Chem. 2009, 5, No. 23. published 20 May 2009

Full Research Paper

The development and evaluation of a continuous flow process for the lipase- mediated oxidation of alkenes

Charlotte Wiles, Marcus J. Hammond, Paul Watts

Beilstein J. Org. Chem. 2009, 5, No. 27. published 02 Jun 2009

Full Research Paper

From discovery to production: Scale- out of continuous flow meso reactors

Peter Styring, Ana I. R. Parracho

Beilstein J. Org. Chem. 2009, 5, No. 29. published 09 Jun 2009

Full Research Paper

Controlling hazardous chemicals in microreactors: Synthesis with iodine azide

Johan C. Brandt, Thomas Wirth

Beilstein J. Org. Chem. 2009, 5, No. 30. published 12 Jun 2009

Full Research Paper

Radical carbonylations using a continuous microflow system

Takahide Fukuyama, Md. Taifur Rahman, Naoya Kamata, Ilhyong Ryu

Beilstein J. Org. Chem. 2009, 5, No. 34. published 13 Jul 2009

Preliminary Communication

Gold film- catalysed benzannulation by Microwave- Assisted, Continuous Flow Organic Synthesis (MACOS)

Gjergji Shore, Michael Tsimerman, Michael G. Organ

Beilstein J. Org. Chem. 2009, 5, No. 35. published 21 Jul 2009

Full Research Paper

Acid- mediated reactions under microfluidic conditions: A new strategy for practical synthesis of biofunctional natural products

Katsunori Tanaka, Koichi Fukase

Beilstein J. Org. Chem. 2009, 5, No. 40. published 20 Aug 2009

Review

Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups

Julien Rolland, Xacobe C. Cambeiro, Carles Rodríguez-Escrich, Miquel A. Pericàs

Beilstein J. Org. Chem. 2009, 5, No. 56. published 15 Oct 2009

Full Research Paper

Flow through reactors for organic chemistry: directly electrically heated tubular mini reactors as an enabling technology for organic synthesis

Ulrich Kunz, Thomas Turek

Beilstein J. Org. Chem. 2009, 5, No. 70. published 30 Nov 2009

Full Research Paper