Chemistry in flow systems
Leibniz Universität Hannover
The automation of chemical synthesis with the resulting savings in time and materials and reduction in the use of environmentally harmful chemicals has been the goal of many academic and industrial chemists for a long time. Over recent years the application of flow devices in laboratories has been gaining acceptance with increased sophistication in their control and ease of use. The advantages that flow devices bring are many, for example: easier scale up, better and precise control of reaction conditions, better mixing, easier handling of unstable intermediates, in-system purification. An important field of research is the optimization and adaptation of known reactions and reaction sequences for use in flow systems. Continuous-flow processes can be further improved by techniques that use immobilized reagents or catalysts, or by using fixed bed reactors in parallel. These developments in flow techniques using mini and micro flow reactors have initiated changes that will pave the way for a technological step forward in chemical synthesis.
Chemistry in flow systemsAndreas Kirschning Beilstein J. Org. Chem. 2009, 5, No. 15. published 29 Apr 2009 Editorial
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Synthesis of unsymmetrically substituted biaryls via sequential lithiation of dibromobiaryls using integrated microflow systemsAiichiro Nagaki, Naofumi Takabayashi, Yutaka Tomida, Jun-ichi Yoshida Beilstein J. Org. Chem. 2009, 5, No. 16. published 29 Apr 2009 Full Research Paper
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A biphasic oxidation of alcohols to aldehydes and ketones using a simplified packed- bed microreactorAndrew Bogdan, D. Tyler McQuade Beilstein J. Org. Chem. 2009, 5, No. 17. published 29 Apr 2009 Full Research Paper
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Oxidative cyclization of alkenols with Oxone using a miniflow reactorYoichi M. A. Yamada, Kaoru Torii, Yasuhiro Uozumi Beilstein J. Org. Chem. 2009, 5, No. 18. published 29 Apr 2009 Preliminary Communication
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Asymmetric reactions in continuous flowXiao Yin Mak, Paola Laurino, Peter H. Seeberger Beilstein J. Org. Chem. 2009, 5, No. 19. published 29 Apr 2009 Review
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Polyionic polymers – heterogeneous media for metal nanoparticles as catalyst in Suzuki–Miyaura and Heck–Mizoroki reactions under flow conditionsKlaas Mennecke, Andreas Kirschning Beilstein J. Org. Chem. 2009, 5, No. 21. published 08 May 2009 Full Research Paper
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Continuous flow based catch and release protocol for the synthesis of α-ketoestersAlessandro Palmieri, Steven V. Ley, Anastasios Polyzos, Mark Ladlow, Ian R. Baxendale Beilstein J. Org. Chem. 2009, 5, No. 23. published 20 May 2009 Full Research Paper
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The development and evaluation of a continuous flow process for the lipase- mediated oxidation of alkenesCharlotte Wiles, Marcus J. Hammond, Paul Watts Beilstein J. Org. Chem. 2009, 5, No. 27. published 02 Jun 2009 Full Research Paper
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From discovery to production: Scale- out of continuous flow meso reactorsPeter Styring, Ana I. R. Parracho Beilstein J. Org. Chem. 2009, 5, No. 29. published 09 Jun 2009 Full Research Paper
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Controlling hazardous chemicals in microreactors: Synthesis with iodine azideJohan C. Brandt, Thomas Wirth Beilstein J. Org. Chem. 2009, 5, No. 30. published 12 Jun 2009 Full Research Paper
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Radical carbonylations using a continuous microflow systemTakahide Fukuyama, Md. Taifur Rahman, Naoya Kamata, Ilhyong Ryu Beilstein J. Org. Chem. 2009, 5, No. 34. published 13 Jul 2009 Preliminary Communication
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Gold film- catalysed benzannulation by Microwave- Assisted, Continuous Flow Organic Synthesis (MACOS)Gjergji Shore, Michael Tsimerman, Michael G. Organ Beilstein J. Org. Chem. 2009, 5, No. 35. published 21 Jul 2009 Full Research Paper
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Acid- mediated reactions under microfluidic conditions: A new strategy for practical synthesis of biofunctional natural productsKatsunori Tanaka, Koichi Fukase Beilstein J. Org. Chem. 2009, 5, No. 40. published 20 Aug 2009 Review
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Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groupsJulien Rolland, Xacobe C. Cambeiro, Carles Rodríguez-Escrich, Miquel A. Pericàs Beilstein J. Org. Chem. 2009, 5, No. 56. published 15 Oct 2009 Full Research Paper
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Flow through reactors for organic chemistry: directly electrically heated tubular mini reactors as an enabling technology for organic synthesisUlrich Kunz, Thomas Turek Beilstein J. Org. Chem. 2009, 5, No. 70. published 30 Nov 2009 Full Research Paper
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