Chemistry in flow systems II

  1. editorImage
  1. Editor: Prof. Andreas Kirschning
    Leibniz Universität Hannover

This is the second Thematic Series on chemistry in flow systems. Flow chemistry is an enabling technology that was introduced to the laboratories of synthetic organic chemists around ten years ago and has flourished now for about half a decade. This series contains representative examples of fields in organic synthesis where continuous flow conditions have already made a significant impact. First of all, there is the application to photochemistry, which has the chance of experiencing a renaissance particularly in an industrial environment. Second, flow chemistry lends itself naturally to the synthesis and direct application of reactive intermediates or reactive reagents, which are difficult to handle in a batch reactor. And third, new heating concepts, including inductive heating, are rendered possible, allowing accelerated synthesis under pressure, up to supercritical conditions, but whereby only a small volume of the reaction mixture inside the flow reactor is exposed to these extreme conditions.

See also the Thematic Series:
Chemistry in flow systems III
Chemistry in flow systems

See videos about flow chemistry at Beilstein TV.

Chemistry in flow systems II

  1. Andreas Kirschning
  • Editorial
  • Published 02 Aug 2011

Beilstein J. Org. Chem. 2011, 7, 1046–1047, doi:10.3762/bjoc.7.119

Unusual behavior in the reactivity of 5-substituted-1H-tetrazoles in a resistively heated microreactor

  1. Bernhard Gutmann,
  2. Toma N. Glasnov,
  3. Tahseen Razzaq,
  4. Walter Goessler,
  5. Dominique M. Roberge and
  6. C. Oliver Kappe
  • Full Research Paper
  • Published 21 Apr 2011

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2011, 7, 503–517, doi:10.3762/bjoc.7.59

  • Letter
  • Published 31 May 2011

Beilstein J. Org. Chem. 2011, 7, 735–739, doi:10.3762/bjoc.7.83

Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination

  1. Jessica R. Breen,
  2. Graham Sandford,
  3. Dmitrii S. Yufit,
  4. Judith A. K. Howard,
  5. Jonathan Fray and
  6. Bhairavi Patel
  • Full Research Paper
  • Published 02 Aug 2011

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  • Supp. Info

  • Video

Beilstein J. Org. Chem. 2011, 7, 1048–1054, doi:10.3762/bjoc.7.120

  • Full Research Paper
  • Published 02 Aug 2011

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  • Supp. Info

Beilstein J. Org. Chem. 2011, 7, 1055–1063, doi:10.3762/bjoc.7.121

  • Full Research Paper
  • Published 02 Aug 2011

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  • Supp. Info

Beilstein J. Org. Chem. 2011, 7, 1064–1069, doi:10.3762/bjoc.7.122

A practical microreactor for electrochemistry in flow

  1. Kevin Watts,
  2. William Gattrell and
  3. Thomas Wirth
  • Full Research Paper
  • Published 15 Aug 2011

Beilstein J. Org. Chem. 2011, 7, 1108–1114, doi:10.3762/bjoc.7.127

Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones

  1. Farhan R. Bou-Hamdan,
  2. François Lévesque,
  3. Alexander G. O'Brien and
  4. Peter H. Seeberger
  • Letter
  • Published 17 Aug 2011

Beilstein J. Org. Chem. 2011, 7, 1124–1129, doi:10.3762/bjoc.7.129

Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis

  1. Marian C. Bryan,
  2. David Wernick,
  3. Christopher D. Hein,
  4. James V. Petersen,
  5. John W. Eschelbach and
  6. Elizabeth M. Doherty
  • Full Research Paper
  • Published 22 Aug 2011

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  • Supp. Info

Beilstein J. Org. Chem. 2011, 7, 1141–1149, doi:10.3762/bjoc.7.132

Scaling up of continuous-flow, microwave-assisted, organic reactions by varying the size of Pd-functionalized catalytic monoliths

  1. Ping He,
  2. Stephen J. Haswell,
  3. Paul D. I. Fletcher,
  4. Stephen M. Kelly and
  5. Andrew Mansfield
  • Full Research Paper
  • Published 23 Aug 2011

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  • Supp. Info

Beilstein J. Org. Chem. 2011, 7, 1150–1157, doi:10.3762/bjoc.7.133

  • Letter
  • Published 24 Aug 2011

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  • Supp. Info

Beilstein J. Org. Chem. 2011, 7, 1158–1163, doi:10.3762/bjoc.7.134

The Eschenmoser coupling reaction under continuous-flow conditions

  1. Sukhdeep Singh,
  2. J. Michael Köhler,
  3. Andreas Schober and
  4. G. Alexander Groß
  • Full Research Paper
  • Published 25 Aug 2011

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  • Supp. Info

Beilstein J. Org. Chem. 2011, 7, 1164–1172, doi:10.3762/bjoc.7.135

  • Letter
  • Published 15 Sep 2011

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Beilstein J. Org. Chem. 2011, 7, 1288–1293, doi:10.3762/bjoc.7.149

  • Review
  • Published 30 Sep 2011

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Beilstein J. Org. Chem. 2011, 7, 1347–1359, doi:10.3762/bjoc.7.159

  • Full Research Paper
  • Published 04 Oct 2011

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Beilstein J. Org. Chem. 2011, 7, 1360–1371, doi:10.3762/bjoc.7.160

  • Full Research Paper
  • Published 14 Oct 2011

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Beilstein J. Org. Chem. 2011, 7, 1412–1420, doi:10.3762/bjoc.7.165

  • Full Research Paper
  • Published 20 Oct 2011

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  • Supp. Info

  • Video

Beilstein J. Org. Chem. 2011, 7, 1441–1448, doi:10.3762/bjoc.7.168

Coupled chemo(enzymatic) reactions in continuous flow

  1. Ruslan Yuryev,
  2. Simon Strompen and
  3. Andreas Liese
  • Review
  • Published 24 Oct 2011

  • PDF

Beilstein J. Org. Chem. 2011, 7, 1449–1467, doi:10.3762/bjoc.7.169

Continuous-flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyproline

  1. Xacobe C. Cambeiro,
  2. Rafael Martín-Rapún,
  3. Pedro O. Miranda,
  4. Sonia Sayalero,
  5. Esther Alza,
  6. Patricia Llanes and
  7. Miquel A. Pericàs
  • Full Research Paper
  • Published 31 Oct 2011

Beilstein J. Org. Chem. 2011, 7, 1486–1493, doi:10.3762/bjoc.7.172

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

  1. Kimberley A. Roper,
  2. Heiko Lange,
  3. Anastasios Polyzos,
  4. Malcolm B. Berry,
  5. Ian R. Baxendale and
  6. Steven V. Ley
  • Full Research Paper
  • Published 08 Dec 2011

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  • Supp. Info

  • Video

Beilstein J. Org. Chem. 2011, 7, 1648–1655, doi:10.3762/bjoc.7.194

Continuous proline catalysis via leaching of solid proline

  1. Suzanne M. Opalka,
  2. Ashley R. Longstreet and
  3. D. Tyler McQuade
  • Full Research Paper
  • Published 14 Dec 2011

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2011, 7, 1671–1679, doi:10.3762/bjoc.7.197

  • Full Research Paper
  • Published 15 Dec 2011

Beilstein J. Org. Chem. 2011, 7, 1680–1687, doi:10.3762/bjoc.7.198

  • Full Research Paper
  • Published 23 Feb 2012

  • PDF

Beilstein J. Org. Chem. 2012, 8, 300–307, doi:10.3762/bjoc.8.32

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