Antibiotic and cytotoxic peptides

  1. editorImage
  1. Editor: Prof. Norbert Sewald
    Universität Bielefeld

Through evolution, nature has provided practically all organisms with secondary metabolites: chemical compounds that provide the producing species with specific protective mechanisms or other advantages. Among these, there are, e.g., peptides that display antibiotic/antimicrobial activity. These have been isolated from plants, invertebrates, vertebrates, and humans, but also from microorganisms. Some antibiotic peptides are an essential part of innate immunity, which has evolved in most organisms to combat microbial challenge. In addition, antimicrobial peptides sometimes also display cytotoxicity against mammalian cells.

  • Editorial
  • Published 24 Jul 2012

Beilstein J. Org. Chem. 2012, 8, 1144–1145, doi:10.3762/bjoc.8.127

Similarity analysis, synthesis, and bioassay of antibacterial cyclic peptidomimetics

  1. Workalemahu M. Berhanu,
  2. Mohamed A. Ibrahim,
  3. Girinath G. Pillai,
  4. Alexander A. Oliferenko,
  5. Levan Khelashvili,
  6. Farukh Jabeen,
  7. Bushra Mirza,
  8. Farzana Latif Ansari,
  9. Ihsan ul-Haq,
  10. Said A. El-Feky and
  11. Alan R. Katritzky
  • Full Research Paper
  • Published 24 Jul 2012

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Beilstein J. Org. Chem. 2012, 8, 1146–1160, doi:10.3762/bjoc.8.128

Partial thioamide scan on the lipopeptaibiotic trichogin GA IV. Effects on folding and bioactivity

  1. Marta De Zotti,
  2. Barbara Biondi,
  3. Cristina Peggion,
  4. Matteo De Poli,
  5. Haleh Fathi,
  6. Simona Oancea,
  7. Claudio Toniolo and
  8. Fernando Formaggio
  • Full Research Paper
  • Published 24 Jul 2012

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Beilstein J. Org. Chem. 2012, 8, 1161–1171, doi:10.3762/bjoc.8.129

  • Full Research Paper
  • Published 24 Jul 2012

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Beilstein J. Org. Chem. 2012, 8, 1172–1184, doi:10.3762/bjoc.8.130

Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations

  1. John B. Bremner,
  2. Paul A. Keller,
  3. Stephen G. Pyne,
  4. Mark J. Robertson,
  5. K. Sakthivel,
  6. Kittiya Somphol,
  7. Dean Baylis,
  8. Jonathan A. Coates,
  9. John Deadman,
  10. Dharshini Jeevarajah and
  11. David I. Rhodes
  • Full Research Paper
  • Published 09 Aug 2012

Beilstein J. Org. Chem. 2012, 8, 1265–1270, doi:10.3762/bjoc.8.142

  • Full Research Paper
  • Published 21 Aug 2012

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Beilstein J. Org. Chem. 2012, 8, 1344–1351, doi:10.3762/bjoc.8.154

Synthetic studies towards bottromycin

  1. Stefanie Ackermann,
  2. Hans-Georg Lerchen,
  3. Dieter Häbich,
  4. Angelika Ullrich and
  5. Uli Kazmaier
  • Full Research Paper
  • Published 01 Oct 2012

Beilstein J. Org. Chem. 2012, 8, 1652–1656, doi:10.3762/bjoc.8.189

Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups

  1. H. Bauke Albada,
  2. Alina-Iulia Chiriac,
  3. Michaela Wenzel,
  4. Maya Penkova,
  5. Julia E. Bandow,
  6. Hans-Georg Sahl and
  7. Nils Metzler-Nolte
  • Full Research Paper
  • Published 15 Oct 2012

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Beilstein J. Org. Chem. 2012, 8, 1753–1764, doi:10.3762/bjoc.8.200

Dimerization of a cell-penetrating peptide leads to enhanced cellular uptake and drug delivery

  1. Jan Hoyer,
  2. Ulrich Schatzschneider,
  3. Michaela Schulz-Siegmund and
  4. Ines Neundorf
  • Full Research Paper
  • Published 18 Oct 2012

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Beilstein J. Org. Chem. 2012, 8, 1788–1797, doi:10.3762/bjoc.8.204

Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120

  1. Julia Meier,
  2. Kristin Kassler,
  3. Heinrich Sticht and
  4. Jutta Eichler
  • Full Research Paper
  • Published 31 Oct 2012

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Beilstein J. Org. Chem. 2012, 8, 1858–1866, doi:10.3762/bjoc.8.214

Total synthesis and biological evaluation of fluorinated cryptophycins

  1. Christine Weiß,
  2. Tobias Bogner,
  3. Benedikt Sammet and
  4. Norbert Sewald
  • Full Research Paper
  • Published 23 Nov 2012

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Beilstein J. Org. Chem. 2012, 8, 2060–2066, doi:10.3762/bjoc.8.231

  • Full Research Paper
  • Published 27 Nov 2012

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Beilstein J. Org. Chem. 2012, 8, 2072–2084, doi:10.3762/bjoc.8.233

The multicomponent approach to N-methyl peptides: total synthesis of antibacterial (–)-viridic acid and analogues

  1. Ricardo A. W. Neves Filho,
  2. Sebastian Stark,
  3. Bernhard Westermann and
  4. Ludger A. Wessjohann
  • Full Research Paper
  • Published 28 Nov 2012

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Beilstein J. Org. Chem. 2012, 8, 2085–2090, doi:10.3762/bjoc.8.234

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