Natural products in synthesis and biosynthesis

  1. editorImage
  1. Editor: Dr. Jeroen S. Dickschat
    Technische Universität Braunschweig

This is the second Thematic Series in this journal focused on natural products. While the first series summarized recent research work on the biosynthesis and function of natural products, the present one deals with synthetic and biosynthetic aspects. Of course, the chemistry of nature and as it is used by chemists is one and the same and makes use of the same intrinsic reactivity of molecules. It is fascinating to see that a particular chemical reaction, believed to be invented by man, is in fact already used for millions of years by Mother Nature. An interesting example is the discovery of the Diels–Alder reaction in the 1920s and its later enhancement into an enantioselective reaction by the development of chiral catalysts. But a Diels–Alder reaction also occurs in the biosynthesis of lovastatin and is likely catalysed by a Diels–Alderase, a natural analogue of man-made chiral catalysts.

See also the Thematic Series:
Natural products in synthesis and biosynthesis II

See videos about natural products at Beilstein TV.

  • Editorial
  • Published 19 Sep 2013

Beilstein J. Org. Chem. 2013, 9, 1897–1898, doi:10.3762/bjoc.9.223

Total synthesis of ochnaflavone

  1. Monica M. Ndoile and
  2. Fanie R. van Heerden
  • Full Research Paper
  • Published 08 Jul 2013

Beilstein J. Org. Chem. 2013, 9, 1346–1351, doi:10.3762/bjoc.9.152

Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues

  1. Xu-Wen Li,
  2. Jennifer Herrmann,
  3. Yi Zang,
  4. Philippe Grellier,
  5. Soizic Prado,
  6. Rolf Müller and
  7. Bastien Nay
  • Full Research Paper
  • Published 31 Jul 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 1551–1558, doi:10.3762/bjoc.9.176

New tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei

  1. Annamaria Sinisi,
  2. Barbara Calcinai,
  3. Carlo Cerrano,
  4. Henny A. Dien,
  5. Angela Zampella,
  6. Claudio D’Amore,
  7. Barbara Renga,
  8. Stefano Fiorucci and
  9. Orazio Taglialatela-Scafati
  • Full Research Paper
  • Published 13 Aug 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 1643–1651, doi:10.3762/bjoc.9.188

Synthesis of the reported structure of piperazirum using a nitro-Mannich reaction as the key stereochemical determining step

  1. James C. Anderson,
  2. Andreas S. Kalogirou,
  3. Michael J. Porter and
  4. Graham J. Tizzard
  • Letter
  • Published 23 Aug 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 1737–1744, doi:10.3762/bjoc.9.200

  • Letter
  • Published 29 Aug 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 1768–1773, doi:10.3762/bjoc.9.205

  • Full Research Paper
  • Published 19 Sep 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 1899–1906, doi:10.3762/bjoc.9.224

Stereoselective synthesis of the C79–C97 fragment of symbiodinolide

  1. Hiroyoshi Takamura,
  2. Takayuki Fujiwara,
  3. Isao Kadota and
  4. Daisuke Uemura
  • Letter
  • Published 25 Sep 2013

Beilstein J. Org. Chem. 2013, 9, 1931–1935, doi:10.3762/bjoc.9.228

  • Full Research Paper
  • Published 08 Oct 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 2028–2032, doi:10.3762/bjoc.9.239

The chemistry of isoindole natural products

  1. Klaus Speck and
  2. Thomas Magauer
  • Review
  • Published 10 Oct 2013

Beilstein J. Org. Chem. 2013, 9, 2048–2078, doi:10.3762/bjoc.9.243

  • Full Research Paper
  • Published 24 Oct 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 2194–2201, doi:10.3762/bjoc.9.258

Synthesis and characterization of novel bioactive 1,2,4-oxadiazole natural product analogs bearing the N-phenylmaleimide and N-phenylsuccinimide moieties

  1. Catalin V. Maftei,
  2. Elena Fodor,
  3. Peter G. Jones,
  4. M. Heiko Franz,
  5. Gerhard Kelter,
  6. Heiner Fiebig and
  7. Ion Neda
  • Full Research Paper
  • Published 25 Oct 2013

  • PDF

Beilstein J. Org. Chem. 2013, 9, 2202–2215, doi:10.3762/bjoc.9.259

  • Full Research Paper
  • Published 29 Oct 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 2233–2241, doi:10.3762/bjoc.9.262

Cyclopamine analogs bearing exocyclic methylenes are highly potent and acid-stable inhibitors of hedgehog signaling

  1. Johann Moschner,
  2. Anna Chentsova,
  3. Nicole Eilert,
  4. Irene Rovardi,
  5. Philipp Heretsch and
  6. Athanassios Giannis
  • Full Research Paper
  • Published 31 Oct 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 2328–2335, doi:10.3762/bjoc.9.267

  • Full Research Paper
  • Published 05 Nov 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 2358–2366, doi:10.3762/bjoc.9.271

A protecting group-free synthesis of the Colorado potato beetle pheromone

  1. Zhongtao Wu,
  2. Manuel Jäger,
  3. Jeffrey Buter and
  4. Adriaan J. Minnaard
  • Letter
  • Published 06 Nov 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 2374–2377, doi:10.3762/bjoc.9.273

Biosynthesis of rare hexoses using microorganisms and related enzymes

  1. Zijie Li,
  2. Yahui Gao,
  3. Hideki Nakanishi,
  4. Xiaodong Gao and
  5. Li Cai
  • Review
  • Published 12 Nov 2013

  • PDF

Beilstein J. Org. Chem. 2013, 9, 2434–2445, doi:10.3762/bjoc.9.281

  • Letter
  • Published 12 Nov 2013

Beilstein J. Org. Chem. 2013, 9, 2446–2450, doi:10.3762/bjoc.9.282

  • Full Research Paper
  • Published 18 Nov 2013

Beilstein J. Org. Chem. 2013, 9, 2544–2555, doi:10.3762/bjoc.9.289

The regulation and biosynthesis of antimycins

  1. Ryan F. Seipke and
  2. Matthew I. Hutchings
  • Review
  • Published 19 Nov 2013

  • PDF

Beilstein J. Org. Chem. 2013, 9, 2556–2563, doi:10.3762/bjoc.9.290

  • Full Research Paper
  • Published 19 Nov 2013

Beilstein J. Org. Chem. 2013, 9, 2564–2569, doi:10.3762/bjoc.9.291

The myxocoumarins A and B from Stigmatella aurantiaca strain MYX-030

  1. Tobias A. M. Gulder,
  2. Snežana Neff,
  3. Traugott Schüz,
  4. Tammo Winkler,
  5. René Gees and
  6. Bettina Böhlendorf
  • Full Research Paper
  • Published 20 Nov 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 2579–2585, doi:10.3762/bjoc.9.293

  • Review
  • Published 26 Nov 2013

  • PDF

Beilstein J. Org. Chem. 2013, 9, 2641–2659, doi:10.3762/bjoc.9.300

Halogenated volatiles from the fungus Geniculosporium and the actinomycete Streptomyces chartreusis

  1. Tao Wang,
  2. Patrick Rabe,
  3. Christian A. Citron and
  4. Jeroen S. Dickschat
  • Full Research Paper
  • Published 03 Dec 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 2767–2777, doi:10.3762/bjoc.9.311

  • Full Research Paper
  • Published 10 Dec 2013

  • PDF

Beilstein J. Org. Chem. 2013, 9, 2841–2845, doi:10.3762/bjoc.9.319

  • Full Research Paper
  • Published 13 Dec 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 2866–2876, doi:10.3762/bjoc.9.323

Studies toward bivalent κ opioids derived from salvinorin A: heteromethylation of the furan ring reduces affinity

  1. Thomas A. Munro,
  2. Wei Xu,
  3. Douglas M. Ho,
  4. Lee-Yuan Liu-Chen and
  5. Bruce M. Cohen
  • Full Research Paper
  • Published 20 Dec 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 2916–2924, doi:10.3762/bjoc.9.328

Synthesis and determination of the absolute configuration of (−)-(5R,6Z)-dendrolasin-5-acetate from the nudibranch Hypselodoris jacksoni

  1. I. Wayan Mudianta,
  2. Victoria L. Challinor,
  3. Anne E. Winters,
  4. Karen L. Cheney,
  5. James J. De Voss and
  6. Mary J. Garson
  • Full Research Paper
  • Published 23 Dec 2013

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2013, 9, 2925–2933, doi:10.3762/bjoc.9.329

  • Full Research Paper
  • Published 03 Jan 2014

Beilstein J. Org. Chem. 2014, 10, 7–11, doi:10.3762/bjoc.10.2

  • Full Research Paper
  • Published 10 Jan 2014

Beilstein J. Org. Chem. 2014, 10, 127–133, doi:10.3762/bjoc.10.9

Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1–DNA-complex formation

  1. Midori A. Arai,
  2. Kyoko Uchida,
  3. Samir K. Sadhu,
  4. Firoj Ahmed and
  5. Masami Ishibashi
  • Full Research Paper
  • Published 13 Jan 2014

  • PDF

Beilstein J. Org. Chem. 2014, 10, 134–140, doi:10.3762/bjoc.10.10

  • Review
  • Published 16 Jan 2014

  • PDF

Beilstein J. Org. Chem. 2014, 10, 163–193, doi:10.3762/bjoc.10.14

Synthesis of the B-seco limonoid core scaffold

  1. Hanna Bruss,
  2. Hannah Schuster,
  3. Rémi Martinez,
  4. Markus Kaiser,
  5. Andrey P. Antonchick and
  6. Herbert Waldmann
  • Full Research Paper
  • Published 16 Jan 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 194–208, doi:10.3762/bjoc.10.15

Tanzawaic acids I–L: Four new polyketides from Penicillium sp. IBWF104-06

  1. Louis P. Sandjo,
  2. Eckhard Thines,
  3. Till Opatz and
  4. Anja Schüffler
  • Full Research Paper
  • Published 22 Jan 2014

Beilstein J. Org. Chem. 2014, 10, 251–258, doi:10.3762/bjoc.10.20

Decandrinin, an unprecedented C9-spiro-fused 7,8-seco-ent-abietane from the Godavari mangrove Ceriops decandra

  1. Hui Wang,
  2. Min-Yi Li,
  3. Félix Zongwe Katele,
  4. Tirumani Satyanandamurty,
  5. Jun Wu and
  6. Gerhard Bringmann
  • Full Research Paper
  • Published 27 Jan 2014

Beilstein J. Org. Chem. 2014, 10, 276–281, doi:10.3762/bjoc.10.23

Total synthesis and cytotoxicity of the marine natural product malevamide D and a photoreactive analog

  1. Werner Telle,
  2. Gerhard Kelter,
  3. Heinz-Herbert Fiebig,
  4. Peter G. Jones and
  5. Thomas Lindel
  • Full Research Paper
  • Published 03 Feb 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 316–322, doi:10.3762/bjoc.10.29

  • Letter
  • Published 10 Feb 2014

  • PDF

Beilstein J. Org. Chem. 2014, 10, 361–368, doi:10.3762/bjoc.10.34

  • Full Research Paper
  • Published 11 Feb 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 369–383, doi:10.3762/bjoc.10.35

Preparation of new alkyne-modified ansamitocins by mutasynthesis

  1. Kirsten Harmrolfs,
  2. Lena Mancuso,
  3. Binia Drung,
  4. Florenz Sasse and
  5. Andreas Kirschning
  • Full Research Paper
  • Published 03 Mar 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 535–543, doi:10.3762/bjoc.10.49

  • Full Research Paper
  • Published 06 Mar 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 613–621, doi:10.3762/bjoc.10.52

Synthesis of complex intermediates for the study of a dehydratase from borrelidin biosynthesis

  1. Frank Hahn,
  2. Nadine Kandziora,
  3. Steffen Friedrich and
  4. Peter F. Leadlay
  • Full Research Paper
  • Published 11 Mar 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 634–640, doi:10.3762/bjoc.10.55

  • Full Research Paper
  • Published 17 Mar 2014

Beilstein J. Org. Chem. 2014, 10, 667–671, doi:10.3762/bjoc.10.59

  • Full Research Paper
  • Published 02 Apr 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 761–766, doi:10.3762/bjoc.10.71

Structure elucidation of female-specific volatiles released by the parasitoid wasp Trichogramma turkestanica (Hymenoptera: Trichogrammatidae)

  1. Armin Tröger,
  2. Teris A. van Beek,
  3. Martinus E. Huigens,
  4. Isabel M. M. S. Silva,
  5. Maarten A. Posthumus and
  6. Wittko Francke
  • Full Research Paper
  • Published 02 Apr 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 767–773, doi:10.3762/bjoc.10.72

Amino acid motifs in natural products: synthesis of O-acylated derivatives of (2S,3S)-3-hydroxyleucine

  1. Oliver Ries,
  2. Martin Büschleb,
  3. Markus Granitzka,
  4. Dietmar Stalke and
  5. Christian Ducho
  • Full Research Paper
  • Published 16 May 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1135–1142, doi:10.3762/bjoc.10.113

Heronapyrrole D: A case of co-inspiration of natural product biosynthesis, total synthesis and biodiscovery

  1. Jens Schmidt,
  2. Zeinab Khalil,
  3. Robert J. Capon and
  4. Christian B. W. Stark
  • Letter
  • Published 26 May 2014

Beilstein J. Org. Chem. 2014, 10, 1228–1232, doi:10.3762/bjoc.10.121

Selective allylic hydroxylation of acyclic terpenoids by CYP154E1 from Thermobifida fusca YX

  1. Anna M. Bogazkaya,
  2. Clemens J. von Bühler,
  3. Sebastian Kriening,
  4. Alexandrine Busch,
  5. Alexander Seifert,
  6. Jürgen Pleiss,
  7. Sabine Laschat and
  8. Vlada B. Urlacher
  • Full Research Paper
  • Published 13 Jun 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1347–1353, doi:10.3762/bjoc.10.137

Streptopyridines, volatile pyridine alkaloids produced by Streptomyces sp. FORM5

  1. Ulrike Groenhagen,
  2. Michael Maczka,
  3. Jeroen S. Dickschat and
  4. Stefan Schulz
  • Full Research Paper
  • Published 24 Jun 2014

  • PDF

  • Supp. Info

  • Video

Beilstein J. Org. Chem. 2014, 10, 1421–1432, doi:10.3762/bjoc.10.146

C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog

  1. Sebastian Rabe,
  2. Johann Moschner,
  3. Marina Bantzi,
  4. Philipp Heretsch and
  5. Athanassios Giannis
  • Full Research Paper
  • Published 09 Jul 2014

Beilstein J. Org. Chem. 2014, 10, 1564–1569, doi:10.3762/bjoc.10.161

Synthesis and bioactivity of analogues of the marine antibiotic tropodithietic acid

  1. Patrick Rabe,
  2. Tim A. Klapschinski,
  3. Nelson L. Brock,
  4. Christian A. Citron,
  5. Paul D’Alvise,
  6. Lone Gram and
  7. Jeroen S. Dickschat
  • Letter
  • Published 06 Aug 2014

Beilstein J. Org. Chem. 2014, 10, 1796–1801, doi:10.3762/bjoc.10.188

Sacrolide A, a new antimicrobial and cytotoxic oxylipin macrolide from the edible cyanobacterium Aphanothece sacrum

  1. Naoya Oku,
  2. Miyako Matsumoto,
  3. Kohsuke Yonejima,
  4. Keijiroh Tansei and
  5. Yasuhiro Igarashi
  • Full Research Paper
  • Published 07 Aug 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1808–1816, doi:10.3762/bjoc.10.190

Keep Informed

RSS Feed

Subscribe to our Latest Articles RSS Feed.

Subscribe

Follow the Beilstein-Institut

LinkedIn

Twitter: @BeilsteinInst