Multivalent glycosystems for nanoscience

  1. editorImage
  1. Editor: Prof. Thisbe K. Lindhorst
    Christian-Albrechts-Universität zu Kiel

Carbohydrates constitute the most abundant class of biomolecules on Earth. They exist as small mono- or oligo-saccharides, as large and highly complex polysaccharides, and in conjugation with, for example, proteins and lipids, forming a kingdom of glycoconjugates that are found on every cell surface. It is now generally considered important to be able to synthesize carbohydrates and glycoconjugates, to analyze their structures, and to advance our understanding of the biology of carbohydrates in living systems. The Thematic Series “Synthesis in the glycosciences” and “Synthesis in the glycosciences II” have impressively documented the state of the art in this field of research. Now, a third Thematic Series is presented in which the structural world of natural sugars has been extended towards artificial carbohydrate architectures to achieve potential innovations offered by glycoconjugates. For instance, multivalent glycoconjugates can be used as anti-adhesive drugs against microbial infections. They could be developed into bioimaging agents that can target specific tissues. Indeed, they will certainly find applications in materials science and in medicine, for example, in drug delivery or diagnostics.

See also the Thematic Series:
Multivalency as a chemical organization and action principle

  • Editorial
  • Published 08 Oct 2014

Beilstein J. Org. Chem. 2014, 10, 2345–2347, doi:10.3762/bjoc.10.244

Synthesis of a sucrose dimer with enone tether; a study on its functionalization

  1. Zbigniew Pakulski,
  2. Norbert Gajda,
  3. Magdalena Jawiczuk,
  4. Jadwiga Frelek,
  5. Piotr Cmoch and
  6. Sławomir Jarosz
  • Full Research Paper
  • Published 28 May 2014

Beilstein J. Org. Chem. 2014, 10, 1246–1254, doi:10.3762/bjoc.10.124

Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic

  1. Renato Ribeiro-Viana,
  2. Elena Bonechi,
  3. Javier Rojo,
  4. Clara Ballerini,
  5. Giuseppina Comito,
  6. Barbara Richichi and
  7. Cristina Nativi
  • Full Research Paper
  • Published 10 Jun 2014

  • PDF

Beilstein J. Org. Chem. 2014, 10, 1317–1324, doi:10.3762/bjoc.10.133

Design and synthesis of multivalent neoglycoconjugates by click conjugations

  1. Feiqing Ding,
  2. Li Ji,
  3. Ronny William,
  4. Hua Chai and
  5. Xue-Wei Liu
  • Full Research Paper
  • Published 10 Jun 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1325–1332, doi:10.3762/bjoc.10.134

Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs

  1. Fabrizio Chiodo,
  2. Marco Marradi,
  3. Javier Calvo,
  4. Eloisa Yuste and
  5. Soledad Penadés
  • Full Research Paper
  • Published 12 Jun 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1339–1346, doi:10.3762/bjoc.10.136

Molecular recognition of surface-immobilized carbohydrates by a synthetic lectin

  1. Melanie Rauschenberg,
  2. Eva-Corrina Fritz,
  3. Christian Schulz,
  4. Tobias Kaufmann and
  5. Bart Jan Ravoo
  • Full Research Paper
  • Published 16 Jun 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1354–1364, doi:10.3762/bjoc.10.138

Biantennary oligoglycines and glyco-oligoglycines self-associating in aqueous medium

  1. Svetlana V. Tsygankova,
  2. Alexander A. Chinarev,
  3. Alexander B. Tuzikov,
  4. Nikolai Severin,
  5. Alexey A. Kalachev,
  6. Juergen P. Rabe,
  7. Alexandra S. Gambaryan and
  8. Nicolai V. Bovin
  • Full Research Paper
  • Published 17 Jun 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1372–1382, doi:10.3762/bjoc.10.140

Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores

  1. Mathieu L. Lepage,
  2. Alessandra Meli,
  3. Anne Bodlenner,
  4. Céline Tarnus,
  5. Francesco De Riccardis,
  6. Irene Izzo and
  7. Philippe Compain
  • Letter
  • Published 23 Jun 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1406–1412, doi:10.3762/bjoc.10.144

Carbohydrate PEGylation, an approach to improve pharmacological potency

  1. M. Eugenia Giorgi,
  2. Rosalía Agusti and
  3. Rosa M. de Lederkremer
  • Review
  • Published 25 Jun 2014

  • PDF

Beilstein J. Org. Chem. 2014, 10, 1433–1444, doi:10.3762/bjoc.10.147

Multichromophoric sugar for fluorescence photoswitching

  1. Stéphane Maisonneuve,
  2. Rémi Métivier,
  3. Pei Yu,
  4. Keitaro Nakatani and
  5. Juan Xie
  • Full Research Paper
  • Published 30 Jun 2014

  • PDF

Beilstein J. Org. Chem. 2014, 10, 1471–1481, doi:10.3762/bjoc.10.151

  • Full Research Paper
  • Published 01 Jul 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1482–1487, doi:10.3762/bjoc.10.152

  • Full Research Paper
  • Published 01 Jul 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1488–1494, doi:10.3762/bjoc.10.153

Bis(β-lactosyl)-[60]fullerene as novel class of glycolipids useful for the detection and the decontamination of biological toxins of the Ricinus communis family

  1. Hirofumi Dohi,
  2. Takeru Kanazawa,
  3. Akihiro Saito,
  4. Keita Sato,
  5. Hirotaka Uzawa,
  6. Yasuo Seto and
  7. Yoshihiro Nishida
  • Full Research Paper
  • Published 03 Jul 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1504–1512, doi:10.3762/bjoc.10.155

Why a diaminopyrrolic tripodal receptor binds mannosides in acetonitrile but not in water?

  1. Diogo Vila-Viçosa,
  2. Oscar Francesconi and
  3. Miguel Machuqueiro
  • Full Research Paper
  • Published 03 Jul 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1513–1523, doi:10.3762/bjoc.10.156

  • Full Research Paper
  • Published 04 Jul 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1524–1535, doi:10.3762/bjoc.10.157

  • Full Research Paper
  • Published 08 Jul 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1549–1556, doi:10.3762/bjoc.10.159

  • Full Research Paper
  • Published 08 Jul 2014

Beilstein J. Org. Chem. 2014, 10, 1557–1563, doi:10.3762/bjoc.10.160

Multivalent scaffolds induce galectin-3 aggregation into nanoparticles

  1. Candace K. Goodman,
  2. Mark L. Wolfenden,
  3. Pratima Nangia-Makker,
  4. Anna K. Michel,
  5. Avraham Raz and
  6. Mary J. Cloninger
  • Full Research Paper
  • Published 10 Jul 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1570–1577, doi:10.3762/bjoc.10.162

Photoswitchable precision glycooligomers and their lectin binding

  1. Daniela Ponader,
  2. Sinaida Igde,
  3. Marko Wehle,
  4. Katharina Märker,
  5. Mark Santer,
  6. David Bléger and
  7. Laura Hartmann
  • Full Research Paper
  • Published 15 Jul 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1603–1612, doi:10.3762/bjoc.10.166

Clicked and long spaced galactosyl- and lactosylcalix[4]arenes: new multivalent galectin-3 ligands

  1. Silvia Bernardi,
  2. Paola Fezzardi,
  3. Gabriele Rispoli,
  4. Stefania E. Sestito,
  5. Francesco Peri,
  6. Francesco Sansone and
  7. Alessandro Casnati
  • Full Research Paper
  • Published 23 Jul 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1672–1680, doi:10.3762/bjoc.10.175

  • Letter
  • Published 25 Jul 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1686–1691, doi:10.3762/bjoc.10.177

  • Full Research Paper
  • Published 30 Jul 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1741–1748, doi:10.3762/bjoc.10.181

Synthesis of rigid p-terphenyl-linked carbohydrate mimetics

  1. Maja Kandziora and
  2. Hans-Ulrich Reissig
  • Full Research Paper
  • Published 30 Jul 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1749–1758, doi:10.3762/bjoc.10.182

Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation

  1. Meriem Smadhi,
  2. Sophie de Bentzmann,
  3. Anne Imberty,
  4. Marc Gingras,
  5. Raoudha Abderrahim and
  6. Peter G. Goekjian
  • Full Research Paper
  • Published 25 Aug 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 1981–1990, doi:10.3762/bjoc.10.206

  • Full Research Paper
  • Published 19 Sep 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 2230–2234, doi:10.3762/bjoc.10.231

Expanding the scope of cyclopropene reporters for the detection of metabolically engineered glycoproteins by Diels–Alder reactions

  1. Anne-Katrin Späte,
  2. Verena F. Schart,
  3. Julia Häfner,
  4. Andrea Niederwieser,
  5. Thomas U. Mayer and
  6. Valentin Wittmann
  • Full Research Paper
  • Published 22 Sep 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 2235–2242, doi:10.3762/bjoc.10.232

Synthesis and immunological evaluation of protein conjugates of Neisseria meningitidis X capsular polysaccharide fragments

  1. Laura Morelli,
  2. Damiano Cancogni,
  3. Marta Tontini,
  4. Alberto Nilo,
  5. Sara Filippini,
  6. Paolo Costantino,
  7. Maria Rosaria Romano,
  8. Francesco Berti,
  9. Roberto Adamo and
  10. Luigi Lay
  • Full Research Paper
  • Published 13 Oct 2014

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2014, 10, 2367–2376, doi:10.3762/bjoc.10.247

Keep Informed

RSS Feed

Subscribe to our Latest Articles RSS Feed.

Subscribe

Follow the Beilstein-Institut

LinkedIn

Twitter: @BeilsteinInst