Synthesis of unsymmetrically substituted biaryls via sequential lithiation of dibromobiaryls using integrated microflow systems

Scholarly Works

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• Nagaki, A.; Kim, S.; Miuchi, N.; Yamashita, H.; Hirose, K.; Yoshida, J.-i. Switching between intermolecular and intramolecular reactions using flow microreactors: lithiation of 2-bromo-2′-silylbiphenyls. Organic Chemistry Frontiers 2016, 3, 1250–1253. doi:10.1039/c6qo00257a
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• Kupracz, L.; Kirschning, A. Two-Step Flow Synthesis of Biarylmethanes by Reductive Arylation of Tosylhydrazones. Journal of Flow Chemistry 2013, 3, 11–16. doi:10.1556/jfc-d-12-00021
• Nagaki, A.; Uesugi, Y.; Kim, H.; Yoshida, J.-i. Synthesis of functionalized aryl fluorides using organolithium reagents in flow microreactors. Chemistry, an Asian journal 2013, 8, 705–708. doi:10.1002/asia.201201191
• Seyler, H.; Haid, S.; Kwon, T.-H.; Jones, D. J.; Bäuerle, P.; Holmes, A. B.; Wong, W. W. H. Continuous Flow Synthesis of Organic Electronic Materials – Case Studies in Methodology Translation and Scale-up. Australian Journal of Chemistry 2013, 66, 151–156. doi:10.1071/ch12406
• Nagaki, A. A Flow-Microreactor Approach to Organolithium Reactions. Journal of Synthetic Organic Chemistry, Japan 2013, 71, 1002–1019. doi:10.5059/yukigoseikyokaishi.71.1002
• Nagaki, A.; Yoshida, J.-i. Controlled Polymerization in Flow Microreactor Systems. Controlled Polymerization and Polymeric Structures 2012, 259, 1–50. doi:10.1007/12_2012_179
• Nagaki, A.; Moriwaki, Y.; Haraki, S.; Kenmoku, A.; Takabayashi, N.; Hayashi, A.; Yoshida, J.-i. Cross-Coupling of Aryllithiums with Aryl and Vinyl Halides in Flow Microreactors. Chemistry, an Asian journal 2012, 7, 1061–1068. doi:10.1002/asia.201101019
• Rueping, M.; Bootwicha, T.; Sugiono, E. Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis. Beilstein journal of organic chemistry 2012, 8, 300–307. doi:10.3762/bjoc.8.32
• Nagaki, A.; Matsuo, C.; Kim, S.; Saito, K.; Miyazaki, A.; Yoshida, J.-i. Lithiation of 1,2-Dichloroethene in Flow Microreactors: Versatile Synthesis of Alkenes and Alkynes by Precise Residence-Time Control†. Angewandte Chemie (International ed. in English) 2012, 51, 3245–3248. doi:10.1002/anie.201108932
• Nagaki, A.; Matsuo, C.; Kim, S.; Saito, K.; Miyazaki, A.; Yoshida, J. Lithiation of 1,2‐Dichloroethene in Flow Microreactors: Versatile Synthesis of Alkenes and Alkynes by Precise Residence‐Time Control. Angewandte Chemie 2012, 124, 3299–3302. doi:10.1002/ange.201108932

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