Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

Iqra Rahat, Pooja Yadav, Aditi Singhal, Mohammad Fareed, Jaganathan Raja Purushothaman, Mohammed Aslam, Raju Balaji, Sonali Patil-Shinde and Md. Rizwanullah
Beilstein J. Nanotechnol. 2024, 15, 1473–1497. https://doi.org/10.3762/bjnano.15.118

Cite the Following Article

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects
Iqra Rahat, Pooja Yadav, Aditi Singhal, Mohammad Fareed, Jaganathan Raja Purushothaman, Mohammed Aslam, Raju Balaji, Sonali Patil-Shinde and Md. Rizwanullah
Beilstein J. Nanotechnol. 2024, 15, 1473–1497. https://doi.org/10.3762/bjnano.15.118

How to Cite

Rahat, I.; Yadav, P.; Singhal, A.; Fareed, M.; Purushothaman, J. R.; Aslam, M.; Balaji, R.; Patil-Shinde, S.; Rizwanullah, M. Beilstein J. Nanotechnol. 2024, 15, 1473–1497. doi:10.3762/bjnano.15.118

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 13.3 MB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Bangera, P. D.; Kamath, A. P.; Gopinathan, A.; Keerikkadu, M.; Shetty, A.; Tippavajhala, V. K.; Rathnanand, M. Quality by design-based development of ibrutinib polymer-lipid hybrid nanoparticles for enhanced lymphatic absorption and anticancer efficacy. International journal of pharmaceutics: X 2026, 12, 100593. doi:10.1016/j.ijpx.2026.100593
  • Monika, P.; Nandhini, K.; Pandurangi, S. J.; Hussain, Z.; Malek, T. Moringa oleifera leaf extract encapsulated Eudragit L100 sustained release nanocapsules with antioxidant and anti-inflammatory potential for ulcerative colitis: In vitro study. Next Materials 2026, 12, 102354. doi:10.1016/j.nxmate.2026.102354
  • Verma, K.; Chopra, L.; Pal, K.; Asthana, N. pH-responsive chitosan-based semi-interpenetrating and interpenetrating polymer networks for sustained delivery of risedronate sodium: synthesis, characterization and in-vitro drug release. Journal of Molecular Structure 2026, 1374, 146771. doi:10.1016/j.molstruc.2026.146771
  • Madanahalli Ramesh, M.; Lobo, R.; Hardur Venkatappa, A. Advanced Recovery Strategies for Herbal Bioactives from Pharmaceutical Nanoformulations: A Narrative Review. Revista Brasileira de Farmacognosia 2026, 36. doi:10.1007/s43450-026-00772-x
  • Du, M.; Liu, F.; Shi, L.; Díaz García, A. M.; Asim, M. H.; Wang, H.; Gu, H.; Yang, L.; Li, Q.; Yang, Z.; Zhang, R.; Cai, Y. Superparamagnetic core-shell nanoparticles enable co-delivery of psoralen and paclitaxel for the treatment of triple-negative breast cancer. Nanomedicine : nanotechnology, biology, and medicine 2026, 75, 102966. doi:10.1016/j.nano.2026.102966
  • Mangu, K.; Nadimpalli, A. V.; Chenna, S. R.; Rizwanullah, M. Harnessing TPGS-based Nanoparticles to Overcome Multidrug Resistance in Cancer. Biomedical Materials & Devices 2026. doi:10.1007/s44174-026-00719-9
  • Rahman, M. A.; Rahman, M. M. Lipid-based nanocarriers for anticancer drug delivery: Mechanistic advances, translational challenges, and implications for generic development. Journal of Drug Delivery Science and Technology 2026, 122, 108393. doi:10.1016/j.jddst.2026.108393
  • Dourado, D.; Formiga, F. R.; Alencar, É. d. N.; Reynaud, F. Advances in nanotechnology applied to natural products. Beilstein journal of nanotechnology 2026, 17, 555–558. doi:10.3762/bjnano.17.36
  • Suo, C.; Zhang, L.; Liang, Q.; Chen, C.; Qiu, L.; Li, Z.; Zhang, X.; Xu, X.; Qi, X.; Chen, X.; Feng, J.; Yang, X. Discovery of farnesal from a wild cucumber landrace enables eco-compatible biopesticide development against aphids. Nature communications 2026, 17. doi:10.1038/s41467-026-72502-9
  • Chauhan, R. Advancements in polymer- and lipid-based nanoparticles for enhancing drug solubility, stability, and bioavailability: an integrative and forward-looking review. Frontiers in Nanotechnology 2026, 8. doi:10.3389/fnano.2026.1801422
  • Yu, D.; Park, J.; Kim, T.; Choi, C.; Yuk, S. A.; Kim, H. Nanotechnology-Enabled Delivery of Phytochemicals: From Formulation Strategies to Therapeutic Translation. Journal of Phytomedicine 2026, 1, 4. doi:10.3390/jphytomed1010004
  • Lakshminaryanan, P.; Rani, D. J.; Sugumar, M.; Thamarai, P.; Saravanan, A. Sustainable Synthesis and Characterization of Silver Nanoparticles Using Annona muricata Fruit Parts: A Comparative Study on Phytochemical-mediated Stability. Chemistry Africa 2026, 9. doi:10.1007/s42250-026-01660-6
  • Mohammed, S. J.; Mohammed, A. S.; Ghafoor, D. D.; H. Najmuldeen, H.; Tamar, A. I.; Jalal, D. D.; Alghofaili, F.; Kader, D. A.; Hamarawf, R. F.; Kayani, K. F. Sustainable solutions to antibiotic resistance: a comprehensive review of plant-derived carbon dots and phytochemicals as innovative antibacterial agents. Phytochemistry Reviews 2026, 25, 3357–3395. doi:10.1007/s11101-026-10232-y
  • Ahmed, A. H.; Gangurde, A. B.; Hussain, T.; Atalay, A.; Bender, O.; Anwar, S. Bridging bioactive metabolites of Phoenix dactylifera L. with advanced nanocarrier technologies for mucoadhesive drug delivery. Frontiers in pharmacology 2026, 17, 1748073. doi:10.3389/fphar.2026.1748073
  • Rahangdale, M.; Patel, A.; Dabke, A.; Vankani, A.; Sawant, K. Exploring Hybrid Nanoparticles for Crizotinib Delivery in Lung Cancer Treatment; Design, Optimization, In-vitro and Cell Line Evaluation. Journal of Pharmaceutical Innovation 2026, 21. doi:10.1007/s12247-026-10431-2
  • P., H.; Das, U. Green nanomaterials from Senna (Cassia angustifolia): Phytochemical assisted fabrication of metal and metal oxide nanoparticles. Plant Nano Biology 2026, 15, 100234. doi:10.1016/j.plana.2025.100234
  • Wahid, A.; Khan, S. A.; Huang, J.; Cai, Z.; Xu, G.; Sun, G. NanoPhyto formulations: A promising approach for targeted therapy of gastrointestinal infections, clinical advancements, and future perspectives. Current opinion in pharmacology 2026, 87, 102617. doi:10.1016/j.coph.2026.102617
  • Chhetri, P. PLGA-Based nanocarriers in drug delivery: Advances in block copolymer engineering, hybrid platforms, and clinical translation. Nanomedicine : nanotechnology, biology, and medicine 2026, 72, 102896. doi:10.1016/j.nano.2025.102896
  • Ke, D.; Li, W.; Chen, Q.; Luo, L.; Wang, Y.; Meng, F.; Sun, Y. Application of nanoparticles in the therapeutic management of endometrial cancer. European journal of medical research 2026, 31, 201. doi:10.1186/s40001-025-03623-y
  • Shameli, K.; Kalali, B.; Moeini, H.; Kartouzian, A. Lipid-Based Colloidal Nanocarriers for Site-Specific Drug Delivery. Colloids and Interfaces 2026, 10, 7. doi:10.3390/colloids10010007
Other Beilstein-Institut Open Science Activities