Biomimetic and biodegradable cellulose acetate scaffolds loaded with dexamethasone for bone implants

Scholarly Works

• Celuppi, L. C. M.; Capelezzo, A. P.; Scapinello, J.; Morgan, L. V.; Calza, K. C.; Mucelini, V. B.; Cima, L. B.; Miranda, M. L.; Zeferino, R. C. F.; Müller, L. G.; Fiori, M. A.; Riella, H. G. In vivo biocompatibility and biodegradability of antimicrobial cellulose acetate films with geranyl acetate. Polymer Bulletin 2025, 82, 10801–10818. doi:10.1007/s00289-025-05953-7
• Liesienė, J.; Baniukaitiene, O.; Minseviciene, I. Cellulose-Based Scaffolds with Prolonged Dexamethasone Release for Bone Tissue Engineering. Molecules (Basel, Switzerland) 2025, 30, 2760. doi:10.3390/molecules30132760
• Feng, S.; Lei, N.; Peng, X.; Wei, X.; Luo, Y.; Pu, X.; Yu, X. Mangiferin- and GNPs/ECPP-loaded platform of UH with dual bi-directional dynamic modulation of stem cells/macrophages and osteoblasts/osteoclasts for the prevention of aseptic loosening. Journal of materials chemistry. B 2025, 13, 695–710. doi:10.1039/d4tb02079k
• Celuppi, L. C. M.; Capelezzo, A. P.; Scapinello, J.; Morgan, L. V.; Calza, K. C.; Mucelini, V. B.; Cima, L. B.; Miranda, M. L.; Zeferino, R. C. F.; Müller, L. G.; Fiori, M. A.; Riella, H. In Vivo Biocompatibility and Biodegradability of Antimicrobial Cellulose Acetate Films with Geranyl Acetate. Elsevier BV 2025. doi:10.2139/ssrn.5155751
• Fakhrurrozi, I. F.; Herliansyah, M. K.; Kusmono. Comparison Between Cellulose Nanocrystals and Acetylated-Cellulose Nanocrystals as Reinforcement on 3D Printed-PLA Composites. Lecture Notes in Networks and Systems; Springer Nature Switzerland, 2024; pp 218–226. doi:10.1007/978-3-031-80338-3_21
• Gallet--Pandellé, A.; Rinaldi, R. G.; Dalmas, F.; Kurita, H.; Narita, F. On the use of cellulose acetate as a structural material for parts produced by fused filament fabrication. Cellulose 2024, 31, 9265–9279. doi:10.1007/s10570-024-06092-4
• Xu, W.; Huang, W.; Cai, X.; Dang, Z.; Hao, L.; Wang, L. Dexamethasone Long-Term Controlled Release from Injectable Dual-Network Hydrogels with Porous Microspheres Immunomodulation Promotes Bone Regeneration. ACS applied materials & interfaces 2024, 16, 40581–40601. doi:10.1021/acsami.4c06661
• Kyriakou, S.; Acosta, S.; El Maachi, I.; Rütten, S.; Jockenhoevel, S. A Dexamethasone-Loaded Polymeric Electrospun Construct as a Tubular Cardiovascular Implant. Polymers 2023, 15, 4332. doi:10.3390/polym15214332
• Mai, T. P.; Park, J.-B.; Nguyen, H. D.; Min, K. A.; Moon, C. Current application of dexamethasone-incorporated drug delivery systems for enhancing bone formation. Journal of Pharmaceutical Investigation 2023, 53, 643–665. doi:10.1007/s40005-023-00629-8
• Kumar, K.; Wadhwa, S.; Sharma, A.; Singh, G.; Kumar, R. Natural Carbohydrates-based Nanoparticles: A Review of Pharmaceutical Applications. The Natural Products Journal 2023, 13. doi:10.2174/2210315512666220826145928
• Lei, N.; Peng, X.; Hu, M.; Wan, C.; Yu, X. Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo. ACS biomaterials science & engineering 2023, 9, 2452–2469. doi:10.1021/acsbiomaterials.3c00038
• Alharthi, A. F.; Gouda, M.; Khalaf, M. M.; Elmushyakhi, A.; Abou Taleb, M. F.; Abd El-Lateef, H. M. Cellulose-Acetate-Based Films Modified with Ag2O and ZnS as Nanocomposites for Highly Controlling Biological Behavior for Wound Healing Applications. Materials (Basel, Switzerland) 2023, 16, 777. doi:10.3390/ma16020777
• Bordone, M.; Bettencourt, A. Management of bone diseases: looking at scaffold-based strategies for drug delivery. Drug delivery and translational research 2022, 13, 79–104. doi:10.1007/s13346-022-01191-w
• Madamsetty, V. S.; Mohammadinejad, R.; Uzieliene, I.; Nabavi, N.; Dehshahri, A.; García-Couce, J.; Tavakol, S.; Moghassemi, S.; Dadashzadeh, A.; Makvandi, P.; Pardakhty, A.; Aghaei Afshar, A.; Seyfoddin, A. Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery Systems. ACS biomaterials science & engineering 2022, 8, 1763–1790. doi:10.1021/acsbiomaterials.2c00026
• Tsiapla, A.-R.; Gravalidis, C.; Karagkiozaki, V.; Bakola, V.; Logothetidis, S. Drug delivery nano-scaffold for effective implantation in orthopedic applications. Materials Today: Proceedings 2022, 67, 975–984. doi:10.1016/j.matpr.2022.07.433
• Maia, M. T.; de Brito Soares, A. L.; Caetano, M. A.; Andrade, F. K.; Rodríguez-Castellón, E.; Vieira, R. S. Biomimetic Strontium Substituted Calcium Phosphate Coating for Bone Regeneration. Coatings 2021, 11, 908. doi:10.3390/coatings11080908
• Khuroo, T.; Mohamed, E. M.; Dharani, S.; Afrooz, H.; Ali, S. F. B.; Cook, P. M.; Khan, M. A.; Rahman, Z. Coating characterization by hyperspectroscopy and predictive dissolution models of tablets coated with blends of cellulose acetate and cellulose acetate phthalate. AAPS PharmSciTech 2021, 22, 122. doi:10.1208/s12249-021-01986-z
• dos Santos, A. E. A.; dos Santos, F. V.; Freitas, K. M.; Pimenta, L. P. S.; Andrade, L. O.; Marinho, T. A.; Avelar, G. F.; da Silva, A. B.; Ferreira, R. V. Cellulose acetate nanofibers loaded with crude annatto extract: Preparation, characterization, and in vivo evaluation for potential wound healing applications. Materials science & engineering. C, Materials for biological applications 2020, 118, 111322. doi:10.1016/j.msec.2020.111322
• Wei, Y.; Liu, Z.; Zhu, X.; Jiang, L.; Shi, W.; Wang, Y.; Xu, N.; Gang, F.; Wang, X.; Zhao, L.; Lin, J.; Sun, X. Dual directions to address the problem of aseptic loosening via electrospun PLGA @ aspirin nanofiber coatings on titanium. Biomaterials 2020, 257, 120237. doi:10.1016/j.biomaterials.2020.120237
• Sinha, R.

Explore citations to this article at