Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

Scholarly Works

• Farooq, J.; Sultana, R.; Prabhu, A.; Kayarohanam, S.; Gupta, G.; Subramaniyan, V. Mitigation of 5-Fluorouracil-Induced Nephrotoxicity: The Protective Role of Thymoquinone and Hesperidin in vitro and in vivo. Natural Resources for Human Health 2025, 5, 255–264. doi:10.53365/nrfhh/203179
• Komarova, E. G.; Akimova, E. B.; Kondranova, A. M.; Porokhova, E. D.; Nasibov, T. F.; Syrokvashin, M. M.; Khlusov, I. A. Laser interference microscopy study of the morphometric features of MCF-7 cancer cells contacted with 5-Fluorouracil-loaded calcium phosphate coatings on titanium implants. Materials Chemistry and Physics 2025, 333, 130299. doi:10.1016/j.matchemphys.2024.130299
• Sidhic, J.; Aswathi, M.; Prasad, A.; Tom, A.; Mohan, P.; Sarbadhikary, P.; Narayanankutty, A.; George, S.; Abrahamse, H.; George, B. P. Advancements in metal and metal oxide nanoparticles for targeted cancer therapy and imaging: Mechanisms, applications, and safety concerns. Journal of Drug Delivery Science and Technology 2025, 105, 106622. doi:10.1016/j.jddst.2025.106622
• Zhang, Z.; Fang, C.; Ke, J.; Li, Y.; Duan, M.; Ren, J.; Wang, C. Microneedle drug delivery system based on hyaluronic acid for improving therapeutic efficiency of hypertrophic scars. International journal of biological macromolecules 2025, 297, 139790. doi:10.1016/j.ijbiomac.2025.139790
• Ghotbi, M.; Pourmadadi, M.; Yazdian, F.; Hallajsani, A. Fabrication and characterization of starch/agarose biopolymers containing graphene oxide towards the release of 5-fluorouracil in cancer treatment. Inorganic Chemistry Communications 2024, 170, 113119. doi:10.1016/j.inoche.2024.113119
• Szymczuk, D.; Markiewicz, K. H.; Niemirowicz-Laskowska, K.; Sadowska, A.; Wołosewicz, J.; Car, H.; Wilczewska, A. Z. Magnetic particles with polymeric shells bearing lithocholic and folic acid moieties: Nano-warriors to fight colon cancer. International journal of pharmaceutics 2024, 662, 124503. doi:10.1016/j.ijpharm.2024.124503
• Mai, N. X. D.; Nguyen, H.-V. T.; Phung, T. M.; Le, T. M.; Nguyen, H. T.; Vong, L. B.; Doan, T. L. H. Development of amine-functionalized porous organosilica nanoparticles as pH-responsive drug delivery system. Journal of Drug Delivery Science and Technology 2023, 89, 104995. doi:10.1016/j.jddst.2023.104995
• Mazandarani, A.; Taravati, A.; Mohammadnejad, J.; Yazdian, F. Targeted Anticancer Drug Delivery Using Chitosan, Carbon Quantum Dots, and Aptamers to Deliver Ganoderic Acid and 5-Fluorouracil. Chemistry & biodiversity 2023, 20, e202300659. doi:10.1002/cbdv.202300659
• Neves, A. R.; Albuquerque, T.; Biswas, S.; Costa, D. R. B. Calcium phosphate nanoparticles in therapeutics. Inorganic Nanosystems; Elsevier, 2023; pp 407–435. doi:10.1016/b978-0-323-85784-0.00005-4
• Salahuddin, N.; Ibrahim, E.; El-Kemary, M. Surfactant free-poly(lactic-co-glycolic acid) coated artesunate loaded citrate-functionalized hydroxyapatite nanorods as a nanocapsule for improving artesunate delivery and antitumor efficiency. Ceramics International 2022, 48, 13452–13463. doi:10.1016/j.ceramint.2022.01.223
• Gupta, R.; Vishwakarma, L.; Guleri, S. K.; Kumar, G. 5-Fluorouracil-Impregnated PLGA Coated Gold Nanoparticles for Augmented Delivery to Lung Cancer: In Vitro Investigations. Anti-cancer agents in medicinal chemistry 2022, 22, 2292–2302. doi:10.2174/1871520622666211224103110
• Junzong, C.; Qiu, M.; Zhang, S.; Li, B.-B.; Li, D.; Huang, X.; Qian, Z.-R.; Zhao, J.; Wang, Z.; Tang, D. A calcium phosphate drug carrier loading with 5-fluorouracil achieving a synergistic effect for pancreatic cancer therapy. Journal of colloid and interface science 2021, 605, 263–273. doi:10.1016/j.jcis.2021.07.080
• de Menezes, B. R. C.; Rodrigues, K. F.; Schatkoski, V. M.; Pereira, R. M.; Ribas, R. G.; do Amaral Montanheiro, T. L.; Thim, G. P. Current advances in drug delivery of nanoparticles for respiratory disease treatment. Journal of materials chemistry. B 2021, 9, 1745–1761. doi:10.1039/d0tb01783c
• Mahdi, W. A.; Hussain, A.; Ramzan, M. 5-Fluorouracil Loaded Biogenic and Albumin Capped Gold Nanoparticles Using Bacterial Enzyme—In Vitro-In Silico Gastroplus® Simulation and Prediction. Processes 2020, 8, 1579. doi:10.3390/pr8121579
• Zavareh, H. S.; Pourmadadi, M.; Moradi, A.; Yazdian, F.; Omidi, M. Chitosan/carbon quantum dot/aptamer complex as a potential anticancer drug delivery system towards the release of 5-fluorouracil. International journal of biological macromolecules 2020, 165, 1422–1430. doi:10.1016/j.ijbiomac.2020.09.166
• Entezar-Almahdi, E.; Mohammadi-Samani, S.; Tayebi, L.; Farjadian, F. Recent Advances in Designing 5-Fluorouracil Delivery Systems: A Stepping Stone in the Safe Treatment of Colorectal Cancer. International journal of nanomedicine 2020, 15, 5445–5458. doi:10.2147/ijn.s257700
• Sadallah, L.; Boukhris, A.; Hannache, H.; Gmouh, S. Entrapment of organic fluorophores in calcium phosphate nanoparticles with slow release. Turkish journal of chemistry 2020, 44, 142–154. doi:10.3906/kim-1902-57
• Cai, L.; Sun, X.; He, W.; Hu, R.; Liu, B.; Shen, J.-S. A solvatochromic AIE tetrahydro[5]helicene derivative as fluorescent probes for water in organic solvents and highly sensitive sensors for glyceryl monostearate. Talanta 2019, 206, 120214. doi:10.1016/j.talanta.2019.120214
• Cáceres, B.; Ramírez, A.; Carrillo, E.; Jiménez, G.; Griñán-Lisón, C.; López-Ruiz, E.; Jiménez-Martínez, Y.; Marchal, J. A.; Boulaiz, H. Deciphering the Mechanism of Action Involved in Enhanced Suicide Gene Colon Cancer Cell Killer Effect Mediated by Gef and Apoptin. Cancers 2019, 11, 264. doi:10.3390/cancers11020264
• Zafaryab, M.; Iftikhar, C. M. A. Porous silicon–based nanocarriers for tumor targeting. Drug Delivery and Biomedical Applications of Porous Silicon-Based Nanocarriers; Elsevier; pp 97–134. doi:10.1016/b978-0-443-24802-3.00005-6

Explore citations to this article at