Green synthesis of fluorescent carbon dots from spices for in vitro imaging and tumour cell growth inhibition

Nagamalai Vasimalai, Vânia Vilas-Boas, Juan Gallo, María de Fátima Cerqueira, Mario Menéndez-Miranda, José Manuel Costa-Fernández, Lorena Diéguez, Begoña Espiña and María Teresa Fernández-Argüelles
Beilstein J. Nanotechnol. 2018, 9, 530–544.

Supporting Information

Supporting Information features emission spectra of cinnamon, red chilli and turmeric C-dots, as well as cell viability studies and ESI-QTOF spectra of black pepper C-dots and piperine standard.

Supporting Information File 1: Additional experimental data.
Format: PDF Size: 764.7 KB Download

Cite the Following Article

Green synthesis of fluorescent carbon dots from spices for in vitro imaging and tumour cell growth inhibition
Nagamalai Vasimalai, Vânia Vilas-Boas, Juan Gallo, María de Fátima Cerqueira, Mario Menéndez-Miranda, José Manuel Costa-Fernández, Lorena Diéguez, Begoña Espiña and María Teresa Fernández-Argüelles
Beilstein J. Nanotechnol. 2018, 9, 530–544.

How to Cite

Vasimalai, N.; Vilas-Boas, V.; Gallo, J.; Cerqueira, M. d. F.; Menéndez-Miranda, M.; Costa-Fernández, J. M.; Diéguez, L.; Espiña, B.; Fernández-Argüelles, M. T. Beilstein J. Nanotechnol. 2018, 9, 530–544. doi:10.3762/bjnano.9.51

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 934.2 KB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Zhao, W.; Huang, C.; Guo, X.; Zhu, Y.; Li, Y.; Duan, Y.; Gao, J. A Fluorescence Biosensor Based on Carbon Quantum Dots Prepared from Pomegranate Peel and T-Hg2+-T Mismatch for Hg2+ Detection. Journal of fluorescence 2024. doi:10.1007/s10895-024-03645-5
  • Bartkowski, M.; Zhou, Y.; Nabil Amin Mustafa, M.; Eustace, A. J.; Giordani, S. CARBON DOTS: Bioimaging and Anticancer Drug Delivery. Chemistry (Weinheim an der Bergstrasse, Germany) 2024, 30, e202303982. doi:10.1002/chem.202303982
  • Sahu, V.; Sahoo, S. K. Biogenic synthesis of carbon dots with inbuilt biological activity. Next Nanotechnology 2024, 5, 100034. doi:10.1016/j.nxnano.2023.100034
  • Smrithi, S. P.; Kottam, N.; Madhu, G. M.; Prasanth, G. Development of Fe (Iii) Sensor System Using Carbon Nanodots Derived From Plectranthus amboinicus. Journal of Mines, Metals and Fuels 2023, 2342–2347. doi:10.18311/jmmf/2023/36260
  • Wang, C.-Y.; Ndraha, N.; Wu, R.-S.; Liu, H.-Y.; Lin, S.-W.; Yang, K.-M.; Lin, H.-Y. An Overview of the Potential of Food-Based Carbon Dots for Biomedical Applications. International journal of molecular sciences 2023, 24, 16579. doi:10.3390/ijms242316579
  • Xing, Y.; Chen, X.; Wang, J. Biomass Synthesis of Carbon Dots. Green Development of Photoluminescent Carbon Dots; Royal Society of Chemistry, 2023; pp 27–64. doi:10.1039/9781837671205-00027
  • Mazahir, F.; Sharma, R.; Yadav, A. K. Bioinspired theranostic quantum dots: Paving the road to a new paradigm for cancer diagnosis and therapeutics. Drug discovery today 2023, 28, 103822. doi:10.1016/j.drudis.2023.103822
  • Mindivan, F.; Göktaş, M. The green synthesis of carbon quantum dots (CQDs) and characterization of polycaprolactone (PCL/CQDs) films. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2023, 677, 132446. doi:10.1016/j.colsurfa.2023.132446
  • Sawalha, S.; Abdallah, S.; Barham, A.; Badawi, H.; Barham, Z.; Ghareeb, A.; Misia, G.; Collavini, S.; Silvestri, A.; Prato, M.; Assali, M. Green synthesis of fluorescent carbon nanodots from sage leaves for selective anticancer activity on 2D liver cancer cells and 3D multicellular tumor spheroids. Nanoscale advances 2023, 5, 5974–5982. doi:10.1039/d3na00269a
  • Sattariazar, S.; Nejad Ebrahimi, S.; Arsalani, N.; Kazeminava, F. Encapsulation of thymol and menthol loaded N/S co-doped carbon dots derived from a mixture of herbal extracts as theranostic agents with anticancer properties. Colloids and surfaces. B, Biointerfaces 2023, 232, 113603. doi:10.1016/j.colsurfb.2023.113603
  • Adeola, A. O.; Clermont-Paquette, A.; Piekny, A.; Naccache, R. Advances in the design and use of carbon dots for analytical and biomedical applications. Nanotechnology 2023, 35, 12001–012001. doi:10.1088/1361-6528/acfdaf
  • Nair, A.; Kuppusamy, K.; Nangan, S.; Natesan, T.; Haponiuk, J. T.; Thomas, S.; Ramasubburayan, R.; Gnanasekaran, L.; Selvaraj, M.; Gopi, S. Multifunctional natural derived carbon quantum dots from Withania somnifera (L.) - Antiviral activities against SARS-CoV-2 pseudoviron. Environmental research 2023, 239, 117366. doi:10.1016/j.envres.2023.117366
  • Shareef, S. N.; Narasaiah, B. P.; Madhuri, W.; Vagdevi, K.; Ramnarayan. Carbon Quantum dots doped Chitosan/HPMC nano composites and their Functional, Structural, Morphological, Dielectric and Tensile properties. E3S Web of Conferences 2023, 430, 1149–01149. doi:10.1051/e3sconf/202343001149
  • Ahmed, H. B.; Mikhail, M. M.; Abdallah, A. E. M.; El-Shahat, M.; Emam, H. E. Pyrimidine-5-carbonitrile derivatives as sprout for CQDs proveniences: Antitumor and anti-inflammatory potentiality. Bioorganic chemistry 2023, 141, 106902. doi:10.1016/j.bioorg.2023.106902
  • S., A. K.; M., D. K.; Saikia, M.; N., R. D.; A., S. A review on plant derived carbon quantum dots for bio-imaging. Materials Advances 2023, 4, 3951–3966. doi:10.1039/d3ma00254c
  • Alafeef, M.; Srivastava, I.; Aditya, T.; Pan, D. Carbon Dots: From Synthesis to Unraveling the Fluorescence Mechanism. Small (Weinheim an der Bergstrasse, Germany) 2023, 20, e2303937. doi:10.1002/smll.202303937
  • Fiszka Borzyszkowska, A.; Sulowska, A.; Czaja, P.; Bielicka-Giełdoń, A.; Zekker, I.; Zielińska-Jurek, A. ZnO-decorated green-synthesized multi-doped carbon dots from Chlorella pyrenoidosa for sustainable photocatalytic carbamazepine degradation. RSC advances 2023, 13, 25529–25551. doi:10.1039/d3ra04188c
  • Aghazadeh, H.; Taheri, P.; Aboulhassanzadeh, S.; Aboulhassanzadeh, S.; Sangchooli, T.; Hazrati Dorigh, B.; Farmani Gheshlaghi, E. An herbal bioactive drug compound with a delayed release curve in a PEGylated cationic nano-niosome formulation for cancer cells. Biocatalysis and Agricultural Biotechnology 2023, 51, 102704. doi:10.1016/j.bcab.2023.102704
  • Mandal, T.; Mishra, S. R.; Singh, K.; Agarwalla, H.; Masto, R. E.; Kumar, M.; Singh, V. Fluorescent carbon nanomaterials from coal and its derivatives: structure, properties, and applications. Journal of Nanoparticle Research 2023, 25. doi:10.1007/s11051-023-05780-9
  • Tang, X.; Zhao, Y.; Yu, H.; Cui, S.; Temple, H.; Amador, E.; Gao, Y.; Chen, M.-l.; Wang, S.; Hu, Z.; Chen, W. Concentration-regulated multi-color fluorescent carbon dots for the detection of rifampicin, morin and Al3+. Materials Today Advances 2023, 18, 100383. doi:10.1016/j.mtadv.2023.100383


  • ZHOU NINGLIN; SONG QIUXIAN; SHEN JIAN; ZHANG QICHENG; SUN BAOHONG; SHI SHAOZE; XU WANG; LU TINGYU. Carbon quantum dot with Pericarpium Zanthoxyli as carbon source as well as preparation method and application of carbon quantum dot. CN 113025318 A, June 25, 2021.
Other Beilstein-Institut Open Science Activities